Clinical trials: Cognitive Control, open to volunteers
Parkinson Disease, Freezing of Gait
Remote Mental Practice for Freezing of Gait in Parkinson's Disease
This single-blind, randomized controlled trial investigates the effects of a remotely delivered intervention based on mental practice (MP) combined with physical practice (PP) on freezing of gait (FOG) severity in people with…
- Trial name
- NCT06957405
- Testing
- MPPG (Mental and Physical Practice Group), PPG (Physical Practice Group)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Cognitive Impairment, Perceived Stress
Robot-Assisted Meditation for Older Adults With Cognitive Concerns
While traditional app-based mindfulness meditation programs relying solely on audio guidance have shown potential benefits for older adults, the programs often face challenges such as low engagement.
- Trial name
- NCT07435220
- Testing
- Robot-Guided Meditation, Audio-Only Robot
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Elderly (People Aged 65 or More)
Effects of Physical Exercise and Cognitive Training on Quality of Life in Elderly Adults
The aim of the study is to investigate the effectiveness of three different types of intervention, based on physical exercise and/or cognitive stimulation or training, on quality of life, cognition and mobility, on a population…
- Trial name
- HELIOS (NCT07244536)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Italy
- Volunteers
- 156 people
- Sponsor
- University Hospital of Ferrara
Diabete Type 1, Diabete Type 2
Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals With Prediabetes and Diabetes Mellitus
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of the probiotic LP-LDL® (Lactobacillus plantarum ECGC 13110402) on lipid metabolism, glycemic control, inflammatory biomarkers, and…
- Conditions
- Diabete Type 1, Diabete Type 2, Prediabetes
- Trial name
- NCT07373392
- Testing
- Lactobacillus plantarum ECGC 13110402
- Where
- 2 sites in Denmark
- Volunteers
- 210 people
- Sponsor
- Aalborg University
Schizophrenia Disorder
dACC-Targeted Temporal Interference for Negative and Cognitive Symptoms in Schizophrenia
This randomized, double-blind, sham-controlled trial aims to evaluate the efficacy and safety of dorsal anterior cingulate cortex-targeted temporal interference stimulation in individuals with schizophrenia.
- Trial name
- NCT07658898
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Parkinson's Disease
Prevent Cognitive Decline in GBA-associated Parkinson's Disease
This is a proof-of-concept trial to investigate the efficacy of prasinezumab to slow or prevent cognitive decline in people with Parkinson's disease carrying a severe mutation in the GBA (glucocerebrosidase) gene.
- Trial name
- PreCoDe (NCT07055087)
- Testing
- Prasinezumab, Sodium Chloride
- Where
- 11 sites in France, Germany and 5 more
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Mild Cognitive Impairment (MCI), Amyloid Pathology
Using Light Therapy for Mild Cognitive Impairment
The goal of this clinical trial is to test whether transcranial photobiomodulation (tPBM), a non-invasive brain stimulation technique using near-infrared light, can improve brain blood flow regulation (neurovascular coupling) and…
- Trial name
- LTMC (NCT07651787)
- Testing
- Active Vielight Neuro RX-Duo device -Active transcranial photobiomodulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Haemodialysis, Kidney Failure
Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis
When a person's kidneys are not working properly, they need a life-saving treatment called haemodialysis three times a week to filter the waste and extra fluids from the blood.
- Trial name
- COOL HD (NCT07377500)
- Testing
- Dialysis cooling
- Where
- United Kingdom
- Volunteers
- 356 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Cancer Related Cognitive Difficulties, Breast Cancer Female
Effects of Chemotherapy on Cognitive Function in Breast Cancer Patients & Non-Cancer Control Subjects With Optional Sub-Study Research Brain MRI
Study is enrolling newly diagnosed breast cancer patients about to start chemotherapy and age-matched control participants. The investigator is trying to better understand the prevalence of cognitive difficulties in cancer…
- Trial name
- NCT03137095
- Testing
- Cognitive testing, Research Brain MRI
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Rochester
ADHD
Evaluating a Digital Cognitive Training Intervention in Adults With ADHD
The goal of this clinical trial is to evaluate whether a digital cognitive training program can reduce symptoms of ADHD, improve executive functioning, and decrease problematic internet use in adults aged 18-65 with a diagnosis…
- Trial name
- NCT07050225
- Testing
- Digital Cognitive Training, Digital Non-cognitive Training Intervention
- Volunteers
- 52 people
- Sponsor
- McMaster University
Schizophrenia, Autism Spectrum Disorder
Cerebellar Stimulation and Cognitive Control
The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.
- Conditions
- Schizophrenia, Autism Spectrum Disorder, Bipolar Disorder, Depression
- Trial name
- NCT03217110
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Krystal Parker, PhD
Breast Cancer
Cognitive Training and Exercise for Women With Breast Cancer and Cognitive Impairment
Chemotherapy-related cognitive impairment is a prevalent and distressing condition among breast cancer survivors, adversely affecting memory, attention, and overall cognitive function, thereby diminishing quality of life.
- Trial name
- CHEMO-CogEx (NCT07017530)
- Testing
- Cognitive training, Psychoeducational therapy
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Universidad de Extremadura
Gambling Disorder, Gambling Problem
Contingency Management to Reinforce Attendance to Cognitive Behavioral Treatment for Gambling Disorder
The aim of this study is to conduct a trial to investigate the effectiveness of adding contingency management treatment (CM) to standard care cognitive behavioral therapy (CBT) for the treatment of gambling disorder to increase…
- Trial name
- NCT07016100
- Testing
- Contingency management, Cognitive behavioral therapy/ treatment as usual
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- East Tennessee State University
Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD)
Internet-Based Cognitive Behavioral Therapy With Treatment as Usual for Generalized Anxiety Disorder and Major Depressive Disorder in Taiwan (ICBT-TW)
This study aims to evaluate the effectiveness of internet-based cognitive behavioral therapy (ICBT) combined with treatment as usual (TAU) for adults diagnosed with generalized anxiety disorder (GAD) or major depressive disorder…
- Trial name
- ICBT-TW (NCT07177365)
- Testing
- Internet-Based Cognitive Behavioral Therapy (ICBT), Treatment as Usual (TAU) Only
- Volunteers
- 120 people
- Sponsor
- National Health Research Institutes, Taiwan
Schizophrenia / Schizoaffective Disorder, TMS
Efficacy and Safety of Individualized Sequential Accelerated Theta Burst Stimulation in Improving Cognitive Function in Schizophrenia
The goal of this clinical trial is to learn if sequential dual-site accelerated theta burst stimulation (SD-aTBS) targeting the frontoparietal network and default mode network works to improve cognitive function in adults with…
- Conditions
- Schizophrenia / Schizoaffective Disorder, TMS, Cognitive, PET / MR
- Trial name
- NCT07806877
- Testing
- Sequential Dual-Site Accelerated Theta Burst Stimulation (SD-aTBS)
- Volunteers
- 60 people
- Sponsor
- Central South University
Post Traumatic Stress Disorder
rTMS-augmented Written Exposure Therapy for PTSD
Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD.
- Trial name
- NCT05149534
- Testing
- Written Exposure Therapy, repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- VA Office of Research and Development
Obsessive Compulsive Disorder (OCD)
ZeroOCD: Learn to Overcome Contamination OCD With Your Smartphone
This study is a three-arm randomized controlled trial designed to evaluate the efficacy of a smartphone-based augmented reality (AR) cognitive behavioral therapy (CBT) app, called ZeroOCD, for individuals with elevated…
- Trial name
- ZeroOCD (NCT07194473)
- Testing
- ZeroOCD, Videoconferencing CBT
- Where
- 4 sites in Belgium, Netherlands and 2 more
- Volunteers
- 189 people
- Sponsor
- VU University of Amsterdam
Bulimia Nervosa
Changes in Inhibition and Valuation After Eating
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment.
- Trial name
- NCT05995496
- Testing
- Fasting state, Fed state, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Insomnia
Efficacy of Digital CBT-I Utilizing Embodied Artificial Intelligence Agent in Virtual Reality
The goal of this clinical trial is to evaluate whether a virtually embodied artificial intelligence (AI) agent delivered via VR-enhanced digital cognitive behavioral therapy for insomnia (dCBT-I) can improve insomnia outcomes and…
- Trial name
- NCT07699042
- Testing
- App-based dCBT-I with AI chatbot, VR-enhanced dCBT-I with embodied AI agent
- Where
- Hong Kong
- Volunteers
- 168 people
- Sponsor
- Chinese University of Hong Kong