Clinical trials: Cognitive Decline
Mild Cognitive Impairment
Evaluation the Effect of Acetyl-L-carnitine in Patients With Mild Cognitive Impairment Accompanied With Chronic Cerebrovascular Disease
The purpose of this study is to evaluate the efficacy of Acetyl-L-carnitine in patient with Mild Cognitive Impairment associated with chronic cerebrovascular disease.
- Trial name
- NCT04346862
- Testing
- Acetyl-L-carnitine hydrochloride 500mg
- Where
- South Korea
- Volunteers
- 636 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Alzheimer Disease, Dementia
Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease
This is a 24-month, monocentric, exploratory and observational clinical study aimed at developing and validating a blood-based diagnostic test for Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Disorders, Cognitive Decline
- Trial name
- ADKIT (NCT07294586)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
MCI
Amyloid PET in Patients With Mild Cognitive Impairment and Early Dementia
The National Institute on Aging together with the Alzheimer's Association (NIA-AA) recently proposed the ATN classification which is based upon the pathological processes present in Alzheimer's disease (amyloid, tau and…
- Trial name
- NCT06402370
- Testing
- PET scan
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Ghent
Mild Cognitive Impairment, Probable Alzheimer's Disease
Dietary Treatments for Cognitive Impairment in Older Adults
This trial seeks to establish the feasibility of implementing a ketogenic, modified Atkins diet (MAD) to older adults with mild cognitive impairment (MCI) or early Alzheimer's disease (AD) living in the community.
- Trial name
- NCT02521818
- Testing
- Modified Atkins Diet, NIA Diet for Seniors
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Postoperative Cognitive Dysfunction
Modafinil to Prevent Postoperative Cognitive Decline
Postoperative cognitive dysfunction is a well-recognized complication of surgery. The aim of the study is to investigate whether cognitive dysfunction is reduced by the use of modafinil as shown by neurocognitive testing.The…
- Trial name
- NCT03914118
- Testing
- Preoperative modafinil + postoperative modafinil
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Cognitive Rehabilitation, Brain Injuries
Hypnosis in Working Memory Rehabilitation
Establishment of effective, efficient, and evidence-based interventions in rehabilitation of working memory (WM) deficits after acquired brain injury (ABI) is sorely needed.
- Conditions
- Cognitive Rehabilitation, Brain Injuries, Cognitive Impairment, Working Memory
- Trial name
- NCT05287542
- Testing
- Hypnotic suggestion, Mindfulness
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Community-dwelling Seniors
Dual-task Training to Prevent Cognitive Decline in Community-dwelling Older Adults: A Pilot Pragmatic RCT
Objectives: This study aims to explore the feasibility and acceptance of group-based dual-task training for prevention of cognitive decline in a pragmatic setting for community-dwelling older adults.
- Trial name
- NCT06648707
- Testing
- Dual-task training
- Where
- Hong Kong
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alzheimer Disease
Use of Socially Assistive Robots for Long Term Care Older Adults With Cognitive Impairment and Apathy
The objective of this study is to demonstrate the impact of a socially assistive robot system on reducing apathy among cognitively impaired older adults residing in long term care facilities.
- Trial name
- NCT05178992
- Testing
- Socially Assistive Robot Activity
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Vanderbilt University
Age-related Cognitive Decline
Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive Training
The purpose of this research study is to examine the potential benefits of vortioxetine in combination with at-home computerized cognitive training program to improve cognition, such as memory, attention, and concentration.
- Trial name
- BBS (NCT03272711)
- Testing
- Vortioxetine 10 mg, Cognitive training program
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment
French Memory Support System: A Pilot Study
The purpose of this study is to develop a linguistically and culturally appropriate adaptation of the Memory Support System (MSS), an evidence-based intervention to train persons with mild cognitive impairment (MCI) to complete…
- Trial name
- NCT05253365
- Testing
- Memory Support System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Bruyère Health Research Institute.
Mucopolysaccharidosis I, Cognitive Decline
Extension Study of Intrathecal Enzyme Replacement for Cognitive Decline in MPS I
This is a five-year extension study of the pilot study, "Intrathecal Enzyme Replacement for Cognitive Decline in MPS I". Participants must have completed the pilot study to participate in this study.
- Trial name
- NCT02232477
- Testing
- Intrathecal recombinant human alpha iduronidase
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- agnes chen
Mild Cognitive Impairment, Alzheimer Dementia
Brain Fitness APP for Cognitive Enhancement
Memory and cognitive declines are associated with normal brain aging but are also precursors to dementia, in particular the so called the pandemic of the century, Alzheimer's disease.
- Trial name
- NCT03587012
- Testing
- Brain fitness app, Brain fitness app with tACS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Bipolar Disorder
Metacognitive Training With Bipolar Disorder Patients.
The guiding question of this project is to evaluate the effectiveness of MCT as a form of ToM rehabilitation in patients diagnosed with BD who have deficits in this domain of social cognition.
- Trial name
- NCT04447807
- Testing
- Metacognitive Training, Treatment as Usual
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo
Long COVID, Post-COVID19 Condition
Amantadine Therapy for Cognitive Impairment in Long COVID
This study will look at the effects of amantadine on cognitive function in persons with Long COVID. It will also collect specimens to study possible causes of cognitive symptoms in Long COVID, and whether any lab tests can…
- Conditions
- Long COVID, Post-COVID19 Condition, Post-Acute COVID19 Syndrome
- Trial name
- AmantadineLC (NCT06055244)
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Ohio State University
Right Hemispheric Stroke, Left Hemispheric Stroke
Neural and Cognitive Correlates of Pragmatic Abilities
Pragmatics of language refers to the set of abilities that allow one to use and interpret language according to context and, in general, to communicate effectively.
- Conditions
- Right Hemispheric Stroke, Left Hemispheric Stroke, Traumatic Brain Injury, Right Hemispheric Brain Tumor
- Trial name
- APACS_Neuro (NCT06297044)
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Visual Cognitive Deficits
Evaluation of the Efficacy of Optometric Rehabilitation on Visual Cognitive Deficits in Children
Visual cognitive deficits in children are frequent, with an impact on working and daily activities. Optometric therapy may improve those functions, however few studies have been performed.
- Trial name
- NCT02061501
- Testing
- Optometric therapy during 6 months, Optometric therapy during 12 months
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Strasbourg, France
1- Cancer Patients During Chemotherapy Treatment, 2- Use of Cannabis Comparing to Control Without Cannabis Use
Evaluation Prospectively the Level of Reduction in Cognitive Functions of Cancer Patients Who Are on Active Oncology Treatments and Use Cannabis. The Second Goal is to Identify High-risk Groups for Cognitive Impairment Due to Cannabis Use.
Cannabis sativa is one of the most ancient psychotropic drugs known to humanity. Although most Western countries have outlawed the use of cannabis according to the UN Convention of Psychotropic Substances, an increasing number of…
- Trial name
- NCT01983267
- Testing
- cannabis
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
Dementia, Alzheimer Disease
The Cognition and Flow Study
About the research There are currently 850,000 people living with dementia in the United Kingdom. It is now understand that Alzheimer's disease (AzD) can result from damaged blood vessels in the brain.
- Conditions
- Dementia, Alzheimer Disease, Mild Cognitive Impairment, Aging
- Trial name
- NCT03656107
- Testing
- Cognitive Training
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Cognitively Normal Older Adults, Hypertension
Risk Reduction for Alzheimer's Disease
Physical inactivity, high blood pressure and dyslipidemia are risk factors for Alzheimer's disease (AD) and vascular dementia. Importantly, these risk factors are modifiable with lifestyle changes, pharmacological treatment, or…
- Conditions
- Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Alzheimer's Disease
- Trial name
- rrAD (NCT02913664)
- Testing
- Angiotensin II receptor blocker (ARB, losartan) and calcium channel blocker (CCB, amlodipine), Aerobic Exercise Training, Usual Care
- Where
- 4 sites in United States
- Volunteers
- 513 people
- Sponsor
- University of Texas Southwestern Medical Center
Cognitive Impairment
Therapeutic Intervention Code in a Cognitive Geriatric Unit
The diagnostic and therapeutic progresses, associated with modifications in lifestyle and socio-cultural level of populations, have led to a remarkable increase in life expectancy.
- Trial name
- NCT03408028
- Testing
- Medical File consultation
- Where
- Belgium
- Volunteers
- 310 people
- Sponsor
- Murielle Surquin