Clinical trials: Cognitive Deficits, Mild
Mild Cognitive Impairment (MCI)
Non-invasive Deep Brain Stimulation to Enhance Motor Skill Acquisition in Individuals With Mild Cognitive Impairment
The goal of this study is to investigate the impact of non-invasive deep brain stimulation on motor skill acquisition in individuals with Mild Cognitive Impairment.
- Trial name
- NCT07092839
- Testing
- transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- Friedhelm Hummel
Mild Cognitive Impairment
Effectiveness and Safety of a Digitally Based Multidomain Intervention for Mild Cognitive Impairment
This study is designed to evaluate the preliminary effectiveness and safety of a digitally based multidomain intervention in patients with MCI.
- Trial name
- NCT05059353
- Testing
- Digitally based multidomain intervention
- Where
- Singapore
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Neuroglee Therapeutics
Cognitive Impairment
Effects of Aerobic Exercises on Dual-task Performance and Motor Skills in Children With Mild Cognitive Impairment
Cognition refers to the mental processes involved in gaining knowledge and understanding, encompassing aspects such as thinking, knowing, remembering, judging, and problem-solving.
- Trial name
- NCT06867692
- Testing
- Aerobic Exercise, Light Physical Activity Plan
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a…
- Trial name
- NCT07659964
- Testing
- Metronome
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Mild Cognitive Impairment, Cognitive Impairment
SNIFF - 3-Week Aptar CPS Device
The SNIFF 3-Week Aptar Device study will involve using a device to administer insulin or placebo through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body.
- Conditions
- Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease, Early Onset
- Trial name
- NCT05006599
- Testing
- Insulin (Humulin® R U-100), Aptar Pharma CPS Intranasal Delivery Device
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment
Effect of Ginkgo Biloba Special Extract LI 1370 on Dual-tasking in Patients With MCI
The aim of this study is to evaluate the effects of Ginkgo Biloba Extract (GBE) in executive function-impaired Mild Cognitive Impairment (MCI) patients by assessing gait while walking alone as well as under differing dual-task…
- Trial name
- NCT01046292
- Testing
- Ginkgo biloba
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Nonamnestic Mild Cognitive Impairment, Cognitive Dysfunction
Online Cognitive Rehabilitation of Executive Dysfunction in Nonamnestic MCI
Nonamnestic mild cognitive impairment (naMCI) is a prodromal state characterized by deficits in executive functioning, a collection of higher-order abilities involved in organization, planning, inhibition, and complex reasoning.
- Conditions
- Nonamnestic Mild Cognitive Impairment, Cognitive Dysfunction, Cognitive Disorder, Neurocognitive Disorders
- Trial name
- NCT04503798
- Testing
- Online Goal Management Training
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Baycrest
Amnestic Mild Cognitive Impairment, Interactive Stepping Exercise
Interactive Stepping Exercise on Memory
This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly assigned to either the ISE group or control group. The ISE intervention conducts three times a week for 16 weeks.
- Conditions
- Amnestic Mild Cognitive Impairment, Interactive Stepping Exercise, Memory, Cognitive Function
- Trial name
- NCT04103463
- Testing
- Interactive stepping exercise, Home exercise
- Volunteers
- 30 people
- Sponsor
- National Yang Ming Chiao Tung University
Accidental Falls, Aging
Evaluation of the Effects of a Cognitive-Motor Fall Prevention Program on Fall Risk Factors
The goal of this interventional study is to compare in community dwelling elderly people the effects of two physical activity programs to prevent accident falls : "SILVER XIII EQUILIBRE" program and "VIVIFRAIL" program, on…
- Conditions
- Accidental Falls, Aging, Mild Cognitive Impairment
- Trial name
- 13EVAL (NCT05625828)
- Testing
- Cognitive-motor Physical Activity, Multifactorial Physical Activity
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- EZUS-LYON 1
Cognition Disorders
Brain Imaging and Mental Disorders of Aging Intervention
The goal of this project is to determine if a cholinesterase inhibitor is more effective than placebo in delaying cognitive and brain functional decline in people at risk for Alzheimer's disease.
- Trial name
- NCT00267163
- Testing
- donepezil
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- National Institute on Aging (NIA)
Mild Cognitive Impairment (MCI)
Effects of Mental Stimulation in Patients With Mild Cognitive Impairment
The purpose of this study is to learn if activities that challenge the brain (mentally stimulating activities) can improve memory and other types of thinking in patients with Mild Cognitive Impairment.
- Trial name
- NCT01212692
- Testing
- mentally stimulating activities
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Mild Cognitive Impairment
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders
The primary objective of the study is to evaluate the feasibility of eliciting continuous narrative speech in different neurodegenerative and psychiatric indications, using remote, self-administered speech tasks, as measured by…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia With Lewy Bodies, Dementia, Vascular
- Trial name
- RHAPSODY (NCT04939818)
- Where
- 2 sites in United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Mild to Moderate Alzheimer Disease, Cognitive Impairment
An Efficacy and Safety Study of Sodium Oligo-mannurarate (GV-971) Capsule for the Treatment of Alzheimer's Disease
The primary purpose of this study is to determine the efficacy and safety of Sodium Oligo-mannurarate (GV-971) in 36-week treatment of mild to moderate Alzheimer's disease.
- Trial name
- NCT02293915
- Testing
- Sodium oligo-mannurarate 900mg
- Where
- 16 sites in China
- Volunteers
- 818 people
- Sponsor
- Shanghai Greenvalley Pharmaceutical Co., Ltd.
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment a Patient-Caregiver Behavioral Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT04826315
- Testing
- COPE +
- Where
- United States
- Sponsor
- Duke University
Parkinson's Disease, Mild Cognitive Impairment
Effect of Transcranial Magnetic Stimulation on Cognition and Neural Changes in Parkinson's Disease
Parkinson's disease (PD) affects more than 100,000 Canadians and results in symptoms affecting both motor and cognitive (thinking and memory) functions.
- Trial name
- PD-MCI-TMS (NCT03243214)
- Testing
- TMS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of Calgary
Alzheimer Disease, Mild Cognitive Impairment
MR Elastography of Cognitive Impairment
The purpose of this research is to further investigate the potential of brain stiffness as a novel biomarker for Alzheimer's disease.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT06029114
- Testing
- Magnetic Resonance Elastography (MRE)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Cognitive Impairment, TTM
Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
This project is proposed to be a three-year project. The purposes of this project are to develop and examine physical activity program, cognitive rehabilitation training, and new life-style (combination of exercise and cognitive)…
- Conditions
- Mild Cognitive Impairment, TTM, Physical Activity, Cognitive Rehabilitation
- Trial name
- NCT03545152
- Testing
- Exercise, Cognitive training, New life-style
- Volunteers
- 192 people
- Sponsor
- Tzu-Ting Huang
Mild Cognitive Impairment, Dementia
Evaluation Study for the Chef Anchor 3.0 Program
Objectives: 1. (Primary)To estimate the potential effects of the cooking program on the people with MCI/dementia and their informal caregivers; 2.
- Trial name
- NCT06572748
- Testing
- 10-week programme
- Where
- Hong Kong
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alzheimers Disease
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment [MCI] to mild dementia due to AD).
- Trial name
- TRONTIER 1 (NCT07169578)
- Testing
- Trontinemab
- Where
- 142 sites in United States, Argentina and 11 more
- Volunteers
- 1,101 people
- Sponsor
- Hoffmann-La Roche
Mild Cognitive Impairment
Effect of Perch Essence on Cognitive Function Status in Subjects With Mild Cognitive Impairment
With global population aging, cognitive impairment and dementia have become major public health issues worldwide. According to the 2019 World Alzheimer Report by the Alzheimer's Disease International, there are more than 50…
- Trial name
- NCT07239635
- Testing
- Perch essence, Fish stock
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Taipei Medical University