Clinical trials: Cognitive Deficits, Mild
Mild Cognitive Impairment
Serious Game-based Interventions in Patients With Mild Cognitive Impairment Outside the Clinic
This study will evaluate the therapeutic efficacy of Neuro-World cognitive training games (Woorisoft, S. Korea) in patients with mild cognitive impairment.
- Trial name
- NCT04920123
- Testing
- Neuro-World
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Massachusetts, Amherst
Mild Cognitive Impairment
Enhancing Cognitive Control in Mild Cognitive Impairment Via Non-invasive Brain Stimulation
The overall goal of this project is to improve cognitive control abilities in adults with mild cognitive impairment (MCI) through a form of non-invasive brain stimulation, transcranial alternating current stimulation (tACS).
- Trial name
- NCT04647032
- Testing
- Transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University
Dementia, Mild Cognitive Impairment
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
This study aims to develop, evaluate, and commercialize an in-home supportive technology that is designed to alleviate anxiety, burden, and loneliness in spousal and familial caregivers of individuals with Alzheimer's disease…
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05159583
- Testing
- In-Home Technology System, Limited In-Home Technology
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Alzheimer's Disease
Practice Effects and Amyloid Imaging Using 18F-PIB or Flutemetamol PET and FDG-PET
Alzheimer's disease (AD) is the most common cause of progressive cognitive decline in the United States. AD is characterized by severe impairments in learning, memory and other cognitive abilities that significantly interfere…
- Trial name
- NCT01202994
- Testing
- 18F-Flutemetamol
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Utah
Alzheimer's Disease
Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD
This study will assess the effects of VX-745 on markers of disease in the central nervous system of patients with MCI due to AD or with mild AD.
- Trial name
- NCT02423200
- Testing
- VX-745
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- EIP Pharma Inc
Dementia, Alzheimer Type
A Phase II Study to Assess the Safety, Tolerability and Efficacy of Xanamem™ in Subjects With Mild Dementia Due to AD (XanADu)
This XanADu Phase II study in mild Alzheimer's Disease (AD) is to assess the safety, tolerability and efficacy of Xanamem in subjects with mild dementia due to Alzheimer's Disease.
- Trial name
- XanADu (NCT02727699)
- Testing
- Xanamem™
- Where
- 25 sites in United States, Australia and 1 more
- Volunteers
- 185 people
- Sponsor
- Actinogen Medical
Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Participants With Early Alzheimer's Disease
This study seeks to evaluate the efficacy and safety of ABBV-8E12 in participants with early Alzheimer's disease (AD).
- Trial name
- NCT02880956
- Testing
- ABBV-8E12
- Where
- 68 sites in United States, Australia and 9 more
- Volunteers
- 453 people
- Sponsor
- AbbVie
Dementia, Cognitive Impairment
5-Cog Battery for Detecting Cognitive Impairment and Dementia
Despite the availability of numerous cognitive assessment tools, cognitive impairment related to dementia is frequently under-diagnosed in primary care settings.
- Conditions
- Dementia, Cognitive Impairment, Mild Cognitive Impairment, Neurocognitive Disorders
- Trial name
- 5-Cog (NCT03816644)
- Testing
- 5-Cog, Health Literacy & Grip Assessment
- Where
- United States
- Volunteers
- 1,201 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Herpes Simplex 1
Valacyclovir for Mild Cognitive Impairment
Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic mild cognitive impairment (MCI)…
- Conditions
- Mild Cognitive Impairment, Herpes Simplex 1, Herpes Simplex 2
- Trial name
- VALMCI (NCT04710030)
- Testing
- Valacyclovir hydrochloride 500mg caplet
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
HIV/AIDS, Aging
Psychosocial Intervention for Older HIV+ Adults With HAND
CTNPT 029 will test the feasibility and acceptability of cognitive remediation group therapy in older adults living with HIV who have been diagnosed with HIV-associated neurocognitive disorder (HAND).
- Conditions
- HIV/AIDS, Aging, Mild Cognitive Impairment, Group, Peer
- Trial name
- IN-HAND (NCT03483740)
- Testing
- CRGT, HIV group therapy
- Where
- 3 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Brain Injury, Chronic
Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
The purpose of this study is to determine if hyperbaric oxygen therapy (HBOT) improves the cognitive function of OIF/OEF individuals who have chronic mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT00810615
- Testing
- Hyperbaric oxygen @ 2.4 ATA
- Volunteers
- 50 people
- Sponsor
- San Antonio Military Medical Center
Insomnia, Mild Cognitive Impairment
SleepSMART for Veterans With MCI and Insomnia
Cognitive Behavioral Therapy for Insomnia (CBT-I) is the first-line treatment for chronic insomnia. However, cognitive impairments may limit progress in CBT-I for older Veterans with Mild Cognitive Impairment (MCI).
- Trial name
- SleepSMART (NCT05016960)
- Testing
- Sleep-SMART
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment
SYNchronizing Exercises, Remedies in GaIt and Cognition
The proposed SYNERGIC trial is uniquely designed to evaluate the effect of aerobic and progressive resistance training exercises, combined with cognitive training and Vitamin D3 supplementation, in cognition and mobility in older…
- Trial name
- SYNERGIC (NCT02808676)
- Testing
- Vitamin D3, Exercises (E), Cognitive Training (CT)
- Where
- 6 sites in Canada
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cognitive Dysfunction
Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors With Mild Cognitive Impairment
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- urochester (NCT05258058)
- Testing
- Memory and Adaptation Training-Geriatrics
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allison Magnuson
Healthy, Alzheimer's Disease
A Study of LY2599666 in Healthy Participants and Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD)
The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY2599666 in different groups of people - those who are healthy, those who have mild cognitive impairment due to Alzheimer's…
- Conditions
- Healthy, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT02614131
- Testing
- LY2599666, Solanezumab
- Where
- 5 sites in United States, Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Mild Cognitive Impairment (MCI)
Preventing Cognitive Decline in African Americans With Mild Cognitive Impairment
The goal of this study is to determine whether increasing participation in cognitive, physical, and/or social activities prevents cognitive decline in older African Americans (AAs) with Mild Cognitive Impairment (MCI).
- Trial name
- NCT01299766
- Testing
- Behavioral Activation (BA), Supportive Therapy (ST)
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- Thomas Jefferson University
Alzheimer's Disease, Cognitive Impairment
A Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With Early Alzheimer's Disease
This study is a multicenter, double blind, randomized, placebo-controlled study to evaluate the safety, tolerability and immunogenicity of different doses, regimens and combinations of Tau targeted vaccines in participants with…
- Conditions
- Alzheimer's Disease, Cognitive Impairment, Tauopathies, Mild Cognitive Impairment
- Trial name
- NCT04445831
- Testing
- ACI-35.030, JACI-35.054
- Where
- 9 sites in Finland, Netherlands and 2 more
- Volunteers
- 57 people
- Sponsor
- AC Immune SA
Mild Cognitive Impairment
Applying a Person-Centered Approach to Enhance Cognitive Training in Senior Living Community Residents With Mild Cognitive Impairment
Computerized cognitive interventions (CCIs) have been increasingly widely implemented among older adults with mild cognitive impairment (MCI).
- Trial name
- CogT-PACT (NCT03292705)
- Testing
- PEP, CCI
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Rochester