Clinical trials: Cognitive Deficits, Mild
Mild Cognitive Impairment, Alzheimer's Disease
Hormone and Information Processing Study
The purpose of this study is to examine the effects of testosterone (T) replacement on changes in thinking and memory, as well as mood in older men with mild cognitive impairment (MCI) and low T levels.
- Trial name
- HIP (NCT00539305)
- Testing
- testosterone gel
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
Healthy Volunteers
A Study of LY2886721 in Healthy Participants
The purpose of this phase I study in healthy participants will be to evaluate the safety and tolerability of LY2886721 single and multiple doses, to evaluate how the body handles the drug, and to evaluate the drug's effect on the…
- Trial name
- NCT01534273
- Testing
- LY2886721
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Mild Cognitive Impairment, Cognitive Decline
Brain Health Together: A Live-Streaming Group-Based Digital Program
The purpose of this study is to develop and test a comprehensive Brain Health Together program for older adults living with cognitive decline.
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Cognitive Deterioration, Cognitive Deficits, Mild
- Trial name
- NCT05818423
- Testing
- Brain Health Academy, Brain Health Together, Maintain Brain Health Together
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of California, San Francisco
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Alzheimer's Disease, Mild Cognitive Impairment
Influence of Beta Amyloid Imaging on Care of Patients Cognitive Complaints.
When older patients develop cognitive problems - like memory loss - there may be any of several underlying causes, sometimes occurring in combination.
- Trial name
- NCT02309723
- Testing
- Beta amyloid imaging
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Alzheimer Disease, Mild Cognitive Impairment
Decision Making and Implementation of Aging-in-Place/Long Term Care Plans Among Older Adults
This study seeks to better understand how older adult aging-in-place/long term care decision making and implementation is impacted by age-related changes (e.g.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Long-Term Care Planning
- Trial name
- PYL (NCT03960476)
- Testing
- PlanYourLifespan.org
- Where
- United States
- Volunteers
- 293 people
- Sponsor
- Northwestern University
Cognitive Impairment, Elderly
Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment
This study will measure the oral bioavailability and pharmacokinetics of known bioactive compounds from a standardized Centella asiatica water extract product (CAP) in mildly demented elders on cholinesterase inhibitor therapy.
- Trial name
- NCT03937908
- Testing
- 2g Centella asiatica water extract product, 4g Centella asiatica water extract product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Amnestic Mild Cognitive Impairment
mSIM: Mobile Simultaneous Aerobic Exercise and Memory Training Intervention for Amnestic Mild Cognitive Impairment
The mSIM study involves developing and conducting feasibility testing of a web-based application that will deliver mobile-based simultaneous exercise and memory skills training program (mSIM) for amnesic Mild Cognitive Impairment…
- Trial name
- mSIM (NCT04185298)
- Testing
- mSIM intervention plus activity monitoring, Activity monitoring
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Jennifer Bramen
Posttraumatic Stress Disorder, Depression
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity Pilot
The goal of this pilot study is to develop and implement a larger scale, multi-site stepped collaborative care trial that targets injured patients with presentations of posttraumatic stress disorder (PTSD) and related…
- Conditions
- Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation
- Trial name
- TSOS6 (NCT02335125)
- Testing
- Motivational Interviewing, Cognitive Behavioral Therapy Elements, Psychotropic Drugs
- Volunteers
- 40 people
- Sponsor
- University of Washington
Alzheimer's Disease
A Study of LY3303560 in Healthy Participants and Participants With Alzheimer's Disease (AD)
The purpose of this study is to evaluate the safety and tolerability of the study drug, LY3303560. Side effects and laboratory results will be monitored.
- Trial name
- NCT02754830
- Testing
- LY3303560 - IV, Saline Solution - IV, LY3303560 - SC
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Mild Cognitive Impairment, Cognitive Change
Conversations as a Means to Delay the Onset of Alzheimer's Disease
Past epidemiological studies have demonstrated that larger social networks, or more frequent social interactions, could have potential protective effects on the incidence of Alzheimer's Disease (AD).
- Trial name
- conversation (NCT01571427)
- Testing
- Active social engagement group, Control group
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cognitive Impairment, Depression
Problem Adaptation Therapy for Mild Cognitive Impairment and Depression
The present collaborative R01 study, between Cornell and Johns Hopkins, aims to compare Problem Adaptation Therapy for Mild Cognitively Impaired Older Adults (PATH-MCI) vs.
- Trial name
- PATH-MCI (NCT03043573)
- Testing
- PATH-MCI, Supportive Therapy
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Weill Medical College of Cornell University
Alzheimers Disease, Postoperative Delirium
Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal…
- Conditions
- Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
- Trial name
- MADCO-PC (NCT01993836)
- Testing
- Total intravenous anesthesia with propofol, General anesthesia with isoflurane
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Duke University
Alzheimer Disease, Mild Memory Disturbance
The MObile AssessMENT of Behavioral and Psychological Symptoms of Dementia in Amnestic MCI and AD (MOMENT) Study
The purpose of this research study is to learn whether it is possible and useful for caregivers to report behavioral or psychological symptoms of people with mild memory problems or Alzheimer's disease through a smartphone mobile…
- Conditions
- Alzheimer Disease, Mild Memory Disturbance, Mild Cognitive Impairment
- Trial name
- MOMENT (NCT04482036)
- Testing
- Mobile Phone Application Assessments, Standard Assessments
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cognitive Impairment, Dementia
COcoa Supplement and Multivitamin Outcomes Study for the Mind
The parent trial (COcoa Supplement and Multivitamin Outcomes Study, COSMOS; NCT02422745) is a randomized clinical trial of cocoa extract supplement (containing a total of 500 mg/d flavanols, including 80 mg.
- Conditions
- Cognitive Impairment, Dementia, Aging
- Trial name
- COSMOS-Mind (NCT03035201)
- Where
- United States
- Volunteers
- 2,262 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Late Onset Alzheimer Disease
Measuring Brain Amyloid Plaque Load in Older Adults Using BAY 94-9172
The overall goal of this project is to establish and validate biomarkers associated with the risk and progression of late onset Alzheimer's disease, mild cognitive impairment and cognitive decline.
- Trial name
- NCT01222351
- Testing
- BAY 94-9172 (Florbetaben)
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- New York State Psychiatric Institute
Mild Cognitive Impairment, Prodromal Alzheimer's Disease
Study of AGB101 in Mild Cognitive Impairment Due to Alzheimer's Disease
The primary objective of the study is to evaluate the efficacy of AGB101 on slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) score as compared with placebo…
- Trial name
- HOPE4MCI (NCT03486938)
- Testing
- AGB101 220 mg tablet
- Where
- 24 sites in United States, Canada
- Volunteers
- 164 people
- Sponsor
- AgeneBio
Parkinson Disease, Mild Cognitive Impairment
Mild Cognitive Impairment and Endurance Exercise in Parkinson's Disease
The overall objective of this study is to determine how high intensity endurance exercise affects both cognition and the signs and symptoms of Parkinson's disease as well as if certain brain structures and functions also change…
- Trial name
- NCT03542474
- Testing
- High Intensity Endurance Exercise
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University
Alzheimer's Disease
A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Participants With Early Alzheimer's Disease
The name of this trial is MissionAD1. This phase 3 study consists of a Core and Open Label Extension (OLE) Phase in participants with Early Alzheimer's Disease (EAD), and will be conducted to evaluate the efficacy and safety of…
- Trial name
- MissionAD1 (NCT02956486)
- Testing
- Elenbecestat
- Where
- 258 sites in United States, Argentina and 16 more
- Volunteers
- 2,212 people
- Sponsor
- Eisai Co., Ltd.
Alzheimer's Disease, Amnestic Mild Cognitive Impairment
[18F]MK-6240 Positron Emission Tomography (PET) Tracer First-in-Human Validation Study (MK-6240-001)
This 2-part, open-label study was designed to investigate the safety, tolerability, and efficacy of [18F]MK-6240, a Positron Emission Tomography (PET) imaging agent, for the quantification of neurofibrillary tangle (NFT)…
- Trial name
- NCT02562989
- Testing
- [18F]MK-6240, ~185 MBq, [18F]MK-6240, ~160 MBq
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC