Clinical trials: Cognitive Deficits
Huntington Disease, Alzheimer Disease
Striatum and Hippocampus on Different Time Scales
Time processing is fundamental to survival and goal reaching in humans. Different time scales (seconds, minutes, and beyond) are processed through specific cognitive processes involving different neural representations.
- Trial name
- e-Time (NCT05943054)
- Testing
- Temporal perception tasks
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety Disorders
Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders
This study seeks to develop and test a novel, mechanistic treatment for mitigating cognitive impairment in older adults with anxiety disorders. Anxiety disorders are common, severe, and disabling in older adults.
- Trial name
- Mifepristone (NCT01333098)
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment
Dietary Supplement for the Prevention of Cognitive Decline in a Very Elderly Population.
The purpose of this study is to determine whether an omega-3 fatty acid supplementation is effective in the prevention of progressive cognitive decline in elderly people aged 75 years or older.
- Trial name
- NCT01817101
- Testing
- Omega-3 fatty acid supplementation
- Where
- 3 sites in Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Neurofibromatosis Type 1
Reading Disability in Children With NF1
A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.
- Trial name
- NCT02397967
- Testing
- Neuropsychological assessments
- Where
- 6 sites in France
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Cognitive Disorder
Assessment of the Need to Use Short Cognitive Tests for French General Practitioners/Family Doctors
The prevalence of cognitive disorders is constantly increasing, with 1.2 million patients affected in France in 2016. Dementia is currently the seventh leading cause of death.
- Trial name
- NCT06437847
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Mild Cognitive Impairment
Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1
Project 1: The goal of this research project is to examine usability and acceptance of virtual reality (VR) applications and their efficacy with older adults.
- Trial name
- NCT05811338
- Testing
- Project 1 - Phase 2: VR Program for Social, Activity, and Cognitive Engagement, Project 1 - Phase 2: Tablet for Social, Activity, and Cognitive Engagement
- Where
- 3 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cognitive Impairment, Mild, Cognitive Decline
Efficacy of a Multimodal Brain Health Intervention for Older African Americans
This study tests the feasibility, acceptability, and efficacy of a multimodal intervention (walking, social engagement, and reminiscence), including the use of wearable digital biomarkers, for cognitively healthy and mildly…
- Trial name
- SHARP (NCT04863378)
- Testing
- Walking conversational reminiscence
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Huntington Disease
Dosimetry of [11C]CHDI-180R and [11C]CHDI-626.
A better understanding of the HD pathogenesis mechanisms may lead to a better understanding of disease pathology, progression and development of targeted therapies.
- Trial name
- NCT05224115
- Testing
- [11C]CHDI-00485180-R, [11C]CHDI-00485626
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Schizophrenia
Tryptophan-Kynurenine Pathway Metabolism in the Pathophysiology of Cognitive Impairment in Schizophrenia.
Schizophrenia is a common, long-term mental illness. It causes problems with thoughts, feelings, and behavior, including positive symptoms (hallucinations, delusions), negative symptoms (lack of emotion, motivation), and…
- Trial name
- NCT07162467
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
MCI, Cognitive Ability, General
ViewMind Atlas Cognition
The objective of this study is to demonstrate the clinical validity, analytical validity and safety of ViewMind Atlas as an adjunctive tool to be used by healthcare professionals (HCP) evaluating cognitive impairment in adults…
- Conditions
- MCI, Cognitive Ability, General, Cognitive Decline, Cognition
- Trial name
- VM-Cog (NCT06746844)
- Testing
- ViewMind Atlas™
- Where
- Argentina
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- ViewMind
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
Use of a Mobile Brain-Body Imaging Approach to Evaluate the Effects of Rhythmic Auditory Stimulation on Gait and Brain Function in Alzheimer's Disease
Alzheimer's Disease (AD) is associated with impairments in both gait and cognition, significantly increasing fall risk. Falls are a leading cause of injury-related disability in older adults, and individuals with AD experience a…
- Trial name
- NCT07659964
- Testing
- Metronome
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Cognitive Impairment, Mild, Sleep
Are Cognition and Sleep Affected by Exposure to Carbon Dioxide and Bio Effluents During Sleep?
The aim of the project is to examine whether children's sleep and cognition are affected by exposure to CO2 and other bio effluents during sleep.
- Conditions
- Cognitive Impairment, Mild, Sleep, Environmental Exposure
- Trial name
- NCT03558698
- Testing
- Good ventilation, Ventilation CO2, Poor Ventilation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Sedentary Behavior, Cognitive Impairment
A Physical Activity Program to Disrupt Sedentary Time in Older Latinos
To test the feasibility of an intervention designed to replace sedentary time with physical activity in older Latinos, delivered in their homes to improve cognitive function and brain connectivity.
- Trial name
- PAIS (NCT04507464)
- Testing
- Ecological Momentary Intervention
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD)
Alzheimer's Disease Neuroimaging Initiative 3
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) has been realized in informing the design of therapeutic trials in AD.
- Trial name
- ADNI3 (NCT02854033)
- Where
- 59 sites in United States, Canada
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Alzheimer Dementia, Alzheimer Disease
Treating Hyperexcitability in AD With Levetiracetam
The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic…
- Conditions
- Alzheimer Dementia, Alzheimer Disease, Dementia of Alzheimer Type, Mild Cognitive Impairment
- Trial name
- LeAD (NCT03875638)
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Mild Cognitive Impairment, Mild Dementia
Brain Health & the Microbiome
The GW SMHS supports research in complementary and integrative approaches to treatment of sickness and disease and for health promotion.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Alzheimer Disease 1
- Trial name
- bMicrobiome (NCT06039267)
- Testing
- Gut Microbiome Testing
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- George Washington University
Aging, Cognitive Decline
The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)
Tremendous progress has been made in characterizing the interactions between the central nervous system and the gastrointestinal tract.
- Trial name
- COMBAT (NCT03679533)
- Testing
- Freeze-Dried Cranberry Powder
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of Web-based Training to Educate Physicians in the Methods of Interpreting Florbetapir-PET Scans
This study will investigate the performance of physician readers trained to read florbetapir-PET scans using electronic media training.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neurodegenerative Diseases
- Trial name
- NCT01550549
- Testing
- florbetapir F 18
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Parkinson's Disease, Mild Cognitive Impairment
Longitudinal Study of Mild Cognitive Impairment in Parkinson's Disease
Parkinson's disease (PD) is known for its motor symptoms and affects more than 100,000 Canadians. However, PD patients also show cognitive deficits and neuropsychiatric problems that significantly impair their quality of life.
- Trial name
- PD-MCI (NCT02637089)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.