Clinical trials: Cognitive Deficits
Healthy
A Study in Healthy Men to Test Whether BI 474121 Can Reverse the Memory Problems Caused by Ketamine
To investigate the effect of BI 474121 compared to placebo on ketamine-induced cognitive deficits to predict efficacy in patients with cognitive disorders.
- Trial name
- NCT05451095
- Testing
- BI 474121, Ketamine hydrochloride
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Quality of Life, Cognitive Impairment
Effect of the Mindfulness-Based Health Promotion Program (MBHP) in the Elderly: a RCT
According to the World Health Organization (WHO), it is estimated that by 2025 the number of older people in Brazil will be approximately 33.4 million and it will be the sixth population in absolute numbers of the elderly in the…
- Conditions
- Quality of Life, Cognitive Impairment, Psychological
- Trial name
- NCT03706807
- Testing
- Mindfulness-Based Intervention, Cognitive Stimulation
- Where
- Brazil
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Centro Mente Aberta de Mindfulness
Traumatic Brain Injury, Mild Traumatic Brain Injury
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
Older veterans with a history of mild brain trauma exhibit early cognitive challenges, especially in driving-related tasks. This is attributed to alterations in the brain's excitatory/inhibitory (E/I) balance.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Aging, Cognitive Decline
- Trial name
- BRAIN-SPEED (NCT06217575)
- Testing
- Alpha neurofeedback training, Visual Attention Training
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Alzheimer Disease, Mild Cognitive Impairment
Study to Understand Novel Biomarkers in Researching Dementia
The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- SUNBIRD (NCT06547099)
- Testing
- Clinical tau PET, Clinical amyloid test, Research blood collection
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Physiological Stress, Cognitive Dysfunction
DEEPTIME: Human Adaptation in Time Underground Isolation
The objectives of this scientific expedition are: a/ Evaluation of temporal cognitive perception and collective synchronization in a temporally anomalous universe (underground environment), b/ Influence of group living on the…
- Conditions
- Physiological Stress, Cognitive Dysfunction, Sleep
- Trial name
- DEEPTIME (NCT05603780)
- Testing
- exploratory protocol
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Huntington Disease
Metabolomic Study in Huntington's Disease (METABO-HD)
The purpose of this project is to study Huntington's disease by metabolomic approach.
- Trial name
- NCT03296176
- Testing
- blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Cystic Fibrosis
Assessment of Cognitive Function and Exercise Capacity in Cystic Fibrosis
No studies in the literature have investigated the simultaneous effects of cognitive function, exercise capacity and arterial stiffness in adult patients with CF.
- Trial name
- NCT06175182
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neurodegenerative Diseases
Exploring the Recovery Function of Sleep in Neurodegeneration
The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with regard to the conception of future…
- Trial name
- RFSN (NCT05402488)
- Testing
- Auditory stimulation
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cognition
A Study to Compare Two Medications With an Inactive Medication and Look at the Effect on a Person's Mental Ability
The purpose is to compare solifenacin and oxybutynin with an inactive tablet and assess any potential effects on mental ability.
- Trial name
- SENIOR (NCT01126424)
- Testing
- Solifenacin, Oxybutynin
- Where
- 3 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Cognitive Decline
Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
The aim of this study is to investigate the modulation effects of Baduanjin (BDJ), a simple and innovative mind-body exercise, on cognitive function, resting state functional connectivity, and brain morphometry in individuals…
- Trial name
- BDJ (NCT04009382)
- Testing
- Baduanjin Exercise, Cognitive Fitness Program
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hypoglycemia, Cognitive Impairment
The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study
The purpose of this study is to evaluate the cerebral blood flow in subjects with high and low activity in the renin-angiotensin system (RAS).The renin-angiotensin system is a hormone system which is involved in the regulation of…
- Trial name
- NCT00264641
- Testing
- Human insulin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hypoglycaemia Research Group
Alzheimer's Disease
ADNI: Alzheimer's Disease Neuroimaging Initiative
The purpose of this study is to examine how brain imaging technology can be used with other tests to measure the progression of mild cognitive impairment (MCI) and early Alzheimer's disease (AD).
- Trial name
- NCT00106899
- Testing
- Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Lumbar Puncture (LP)
- Where
- 59 sites in United States, Canada
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Mild Cognitive Impairment
Neurotrack Test Validation Protocol
This protocol describes a study to validate Neurotrack's visual paired comparison task, aimed at early detection and monitoring of memory impairment.
- Trial name
- NCT02608021
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cerebral Microvascular Dysfunction, Cerebral Small Vessel Diseases
PRospective Observation on CErebral microvaScular Structure and Function
This is a population-based prospective cohort study, aiming to assess the prevalence, distributional characteristics, and dynamic change of cerebral small vessel dysfunction in a Chinese community population using advanced…
- Conditions
- Cerebral Microvascular Dysfunction, Cerebral Small Vessel Diseases, Cognitive Dysfunction, Cerebrovascular Disorders
- Trial name
- PROCESS (NCT06579677)
- Testing
- Without any intervention
- Where
- 2 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise
Dementia, Cognitive Decline
Preventing Cognitive Decline: The CITA GO-ON Multi-domain Intervention Study
The GOIZ ZAINDU Gipuzkoa - GO - ON Study is an intervention trial to evaluate the efficacy of dementia prevention strategies in cognitively frail people.
- Conditions
- Dementia, Cognitive Decline, Prevention, Life Style
- Trial name
- CITA GO-ON (NCT04840030)
- Testing
- Multimodal intervention (MM-int)
- Where
- Spain
- Volunteers
- 1,094 people, healthy volunteers welcome
- Sponsor
- Fundacion CITA-alzheimer
Chronic Non-Specific Low Back Pain, Cognitive Decline
The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study
Chronic non-specific low back pain (CNSLBP) is a common condition among older adults and has been associated with an increased risk of executive function impairment.
- Conditions
- Chronic Non-Specific Low Back Pain, Cognitive Decline, Longitudinal Study, Older Adults
- Trial name
- NCT07134699
- Testing
- Participants are not assigned an intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment
Genes, Exercise, Neurocognitive and Neurodegeneration: Community-Based Approach
Whereas the advantageous effects of exercise-training on memory is increasingly recognized, the practicality and clinical usefulness of such interventions in community-dwelling older African Americans (AA)s Mild Cognitively…
- Trial name
- GEMSII (NCT02614365)
- Testing
- Aerobic exercise, Stretch exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Howard University
Alzheimer Disease, Dementia
ANNE Vital Sign System Remote Sleep Assessment
Sleep apnea is characterized by temporary pauses or stops to participant's breathing. Currently, sleep apnea is diagnosed using an in-lab sleep study, which involves spending a night in a sleep laboratory hooked up to wires on…
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Sleep Apnea
- Trial name
- NCT05669495
- Testing
- ANNE Vital Sign System
- Where
- Canada
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Preventive Intervention
Preventive Intervention to Promote Healthy Ageing
The aim of the project is the support of healthy ageing of older adults in acommunity. Efficient educational and psychosocial intervention will besuggested and verified to prevent anxiety, depression, and cognitivedisorders of…
- Trial name
- NCT05637177
- Testing
- Anging Wisely, Music therapy, Reminiscence therapy
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ostrava
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