Clinical trials: Cognitive Deficits
Working Memory, Inhibitory Control
BID WM Digital Intervention in Aging
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1.
- Conditions
- Working Memory, Inhibitory Control, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT06918704
- Testing
- Coherence, Worder
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Delirium, Cognitive Impairment
Preoperative BAMCOG and Cortisol and Postoperative DeltaScan in AVR Patients (Aortic Valve Replacement)
There is lack of attention to preoperative cognitive function and delirium in elderly who underwent surgery. The investigators are investigating different tools that can help to screen for cognitive dysfunction and delirium in…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Dysfunction, Cognitive Dysfunction, Postoperative
- Trial name
- NCT05209555
- Testing
- MoCA, BAMCOG, DeltaScan
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Amyotrophic Lateral Sclerosis, Parkinson Disease
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria
The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for…
- Trial name
- NCT03613038
- Testing
- Phonetic complexity effects on speech motor performance
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Mild Cognitive Impairment, Dementia
Evaluation Study for the Chef Anchor 3.0 Program
Objectives: 1. (Primary)To estimate the potential effects of the cooking program on the people with MCI/dementia and their informal caregivers; 2.
- Trial name
- NCT06572748
- Testing
- 10-week programme
- Where
- Hong Kong
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Alzheimer's Disease (AD), Dementia
Negotiation Training for Family Caregivers of People With Alzheimer's Disease
Family caregivers of people living with Alzheimer's disease and related dementias often experience conflicts and communication challenges when coordinating care, making decisions, and interacting with family members and…
- Conditions
- Alzheimer's Disease (AD), Dementia, Cognitive Impairment
- Trial name
- NCT07859540
- Testing
- NegotiAge, PlanYourLifespan
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cognitive Deficits Related to Internet Use
Usability of a Website for People With Schizophrenia
This study will determine the usability of a website for people with schizophrenia versus other websites designed for the same purpose.
- Trial name
- NCT00177879
- Testing
- website comparison
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cognition Disorders
Southend Imaging Study
The study objective is to correlate global cognition and episodic memory performance to resting state fMRI functional connectivity.
- Trial name
- SIS (NCT02736396)
- Testing
- fMRI, Neuropsychological tests
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mid and South Essex NHS Foundation Trust
Aging, Mild Cognitive Impairment
Application of the Modified Story Memory Technique (mSMT)© to Aging
This study is a double-blind placebo-controlled randomized clinical trial (RCT) to provide Class I evidence in support of or in refute of the efficacy of the modified Story Memory Technique (mSMT) in healthy aging (HA)and in…
- Trial name
- NCT03370224
- Testing
- Memory retraining exercises
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
China HEalthy Aging and Dementia Study (HEAD)
The China HEalthy Aging and Dementia (HEAD) study is a large-scale, community-based, multi-center prospective cohort study covering eastern, northern, southern, and central-western regions of China.
- Conditions
- Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia, Vascular Dementia (VaD)
- Trial name
- NCT07912710
- Where
- 30 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Cognition Disorders
Impact of Glasses for Vision Problems on Cognitive Function in Rural Older Adults
The aim of this project is to explore whether vision correction can effectively slow cognitive decline in older adults. The primary question it seeks to answer is: Can providing free near and/or distance vision correction glasses…
- Trial name
- CLEVER (NCT06836440)
- Testing
- Free Prescription Glasses
- Where
- China
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Yuju Wu
Huntington Disease, Huntington's Disease
REGISTRY - an Observational Study of the European Huntington's Disease Network (EHDN)
This is a multi-centre, multi-national, prospective, observational study of Huntington's disease (HD) with a control group of volunteers to: obtain natural history data on many HD mutation carriers and individuals who are part of…
- Trial name
- REGISTRY (NCT01590589)
- Where
- 140 sites in Austria, Belgium and 15 more
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- European Huntington's Disease Network
Risk Behavior, Cognitive Decline
Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention
Alzheimer's Disease (AD) and other Dementias have far-reaching consequences on the lives of sufferers and their loved ones, not to mention the impact on the healthcare system.
- Trial name
- NCT06748625
- Testing
- Luci Coach-Assisted Intervention
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- LuciLab
Healthy, Mild Cognitive Impairment
Characterization of Cerebral Tau Aggregates With 18F-RO6958948 PET in the ALFA Population
This study will characterize tau tracer retention by Positron Emission Tomography (PET) as a function of amyloid levels transversally and longitudinally.
- Trial name
- NCT04482660
- Testing
- Positron emission tomography with 18F-RO6958948
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Mild Cognitive Impairment
Study of Motor Representations in Healthy Subjects and Amnestic MCI
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
- Trial name
- IRMARCHE (NCT02574182)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment
Gestational Diabetes Mother-infant Cohort
The bi-directional dynamic cohort study is to learn about the effects of prenatal exposure to high blood glucose levels and postnatal nurturing environment factors on delayed language development in children.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment, Cohort Study
- Trial name
- NCT06021691
- Testing
- Acquired nurturing environment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gansu Provincial Maternal and Child Health Care Hospital
Frail Elderly Syndrome, Cognitive Impairment
Investigating My Active and Healthy Aging
This is a multicenter, multicultural, randomized control trial. Participants will be recruited from 10 centers located in Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea and Australia.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Physical Dependence
- Trial name
- my-AHA (NCT03342976)
- Testing
- My-AHA platform
- Where
- Italy
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Delirium, Postoperative Delirium
Stanford PIPRA Validation Study in an Elderly Orthopedic Population
The purpose of this study is to determine the accuracy of an AI-based tool in the prediction of postoperative delirium (POD), in a population at moderately high risk of developing this syndrome (i.e., elderly orthopedic…
- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Trial name
- PIPRA-ORTHO (NCT06567574)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Ageing, Cognitive Decline
Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.
This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function.
- Conditions
- Healthy Ageing, Cognitive Decline, Cardiorespiratory Fitness
- Trial name
- FAB (NCT07443189)
- Testing
- Home-Based HIIT
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Agder
Cognitive Decline, Cognitive Impairment, Mild
Effects of Multimodal Training of Combined Cognitive and/or Physical Training on Cognition and Fitness of Older Adults
The elderly population worldwide is expected to increase exponentially. There will be a higher percentage of older adults suffering cognitive decline in the coming decades.
- Trial name
- MTCCP (NCT04727450)
- Testing
- Cognitive training, physical training, Combination of cognitive and physical training (CCPT)-BIGMAP
- Where
- Hong Kong
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
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