Clinical trials: Cognitive Deficits
Type 2 Diabetes, Insulin Resistance
Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）
This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Cognitive Impairment
- Trial name
- T2DM (NCT06912321)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Attention Deficit/Hyperactivity Disorder
Exercise Effects in Children With Attention Deficit Hyperactivity Disorder
The study will investigate catecholamines responses, and cognitive effects of exercise in children with attention deficit hyperactivity disorder, and the effect of exercise training on these measures.
- Trial name
- NCT00945971
- Testing
- Physical activity
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Parkinson Disease, Impaired Cognition
Cognitive Training in Parkinson Study
This study evaluates the efficacy of an eight-week online cognitive training program on objective and subjective cognitive functions in Parkinson's disease.
- Conditions
- Parkinson Disease, Impaired Cognition, Alteration in Cognition
- Trial name
- cogtips (NCT02920632)
- Testing
- Online cognitive training 1, Online cognitive training 2
- Where
- Netherlands
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Prediabetic State, Insulin Resistance
Macronutrient Effects on Alzheimer's Disease (MEAL-2)
This study compares the effects of a one-month diet high in saturated fat (SF), glycemic index (GI), and salt (Na+) to a diet low in these nutritional parameters on memory and other cognitive functions, on MRI measures of brain…
- Conditions
- Prediabetic State, Insulin Resistance, Middle Age, Prehypertension
- Trial name
- MEAL-2 (NCT02463084)
- Testing
- Low Diet, High Diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Huntington Disease
28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease
The primary purpose of this study is to assess the magnitude of the baseline difference between participants with early Huntington's Disease (HD) and healthy participants (HP) with respect to measures of cognitive performance.
- Trial name
- NCT05358821
- Testing
- SAGE-718
- Where
- 14 sites in United States, Canada
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Supernus Pharmaceuticals, Inc.
Occupational Therapy, Nursing Caries
Spanish Adaptation and Validation of the Everyday Cognition Battery (ECB).
HYPOTHESIS: The Spanish version of the Everyday Cognition Battery Scale (ECB) is valid and reliable in the Spanish population. OBJECTIVES: Providing a validated scale in Spanish to evaluate daily cognition in older adults.
- Conditions
- Occupational Therapy, Nursing Caries, Aging Disorder, Cognitive Disorders
- Trial name
- NCT04169633
- Testing
- Cognitive Function Evaluation
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Aging, MCI
Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation
The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of…
- Trial name
- NCT06633952
- Testing
- MediTrain, Worder, noninvasive neurostimulation device
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Schizophrenia, Attention Deficit Disorder With Hyperactivity (ADHD)
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior.
- Trial name
- NCT07217652
- Testing
- High-resolution fMRI during working memory, cognitive control, and decision-making tasks
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kai Hwang
Cognitive Decline, Dementia
Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults
This study will evaluate the effects of low-intensity strengthening exercise on the brain (thinking and processing speed) for patients with early dementia, compared with normative older adults.
- Conditions
- Cognitive Decline, Dementia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT01264614
- Testing
- Strengthening exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Union College, New York
Mild Cognitive Impairment, So Stated, Mild Dementia
Cognitive/Physical Computer-Game Blended Training With Personalized Brain Network Activation Technology for the Elderly
The study involves a novel Virtual Reality Interface that offers full-body immersion "Alterniity AR" and more specifically computer exercises blended with game activities.
- Conditions
- Mild Cognitive Impairment, So Stated, Mild Dementia, Healthy
- Trial name
- AlterniityAR (NCT02417558)
- Testing
- Alterniity Augmented Reality (AAR), VideoGrade
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- XtremeVRI AG
Mild Cognitive Impairment (MCI)
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease…
- Trial name
- NCT01044758
- Testing
- Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Scopolamine Challenge Study
It is hypothesized that PF-05212377 (SAM-760) will reverse scopolamine induced cognitive impairments in healthy adults subjects.
- Trial name
- NCT01213355
- Testing
- Scopolamine, PF-05212377, Donepezil
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lung Neoplasm, Survivorship
Assessment of Functional Capacity, Pain, Cognitive and Respiratory Functions in Lung Cancer Survivors
Serious side effects occurs with disease and treatments in survival after lung cancer. For this reason, functional capacity, cognitive status, pain perception and respiratory functions may be affected in lung cancer.
- Trial name
- NCT04431921
- Testing
- Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cognitive Impairment, Variable
The Effect of Cognitive Rehabilitation on Cognitive Skills, Academic Performance And Quality of Life in Refugee Children
Children are the most vulnerable group to be affected by war. The long-term effects of exposure to conflict on children's mental, physical and cognitive development have been documented in the context of war and refugee camps.
- Trial name
- NCT05093738
- Testing
- Cognitive Rehabilitation
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Mild Cognitive Impairment, Alzheimer Disease
The China Longitudinal Aging Study of Cognitive Impairment
Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly. The burden of dementia is rising in China, with major medical, social and economic impacts.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia, Vascular, Dementia With Lewy Bodies
- Trial name
- NCT03672448
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Mild Cognitive Impairment, Subjective Cognitive Impairment
CogT pSOPT Intervention Study
(JUSTIFICATION: This is the R33 stage of an NIH funded R21/R33 study. R21 stage (IRB-61727) was focused on intervention development; R33 stage will focus on pilot testing the effect of the intervention.
- Trial name
- NCT06005038
- Testing
- pSOPT, MLA
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep Disorders, Frailty
Impact of Sleep Disorders and Digital Support on Older People's Health
The goal of this observational study is to learn about the effects of sleep disorders on health and ageing in older people over the age of 65.
- Conditions
- Sleep Disorders, Frailty, Cognitive Impairment, Quality of Life
- Trial name
- SOMNUS-DARE (NCT06944600)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Parma
Mild Cognitive Impairment
Measuring the Impact of a Socially Assistive Robot
Due to increasing age and an increasing prevalence rate of neurocognitive disorders such as Mild Cognitive Impairment and dementia, independent living may become challenging.
- Trial name
- NCT04848155
- Testing
- socially assistive robot
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Ghent
Altitude Hypoxia, Ventilation
Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude.
Low oxygen at altitude causes pauses in breathing during sleep, called central sleep apnea. Central sleep apnea causes repeated awakenings and poor sleep.
- Conditions
- Altitude Hypoxia, Ventilation, Sleep, Oxidative Stress
- Trial name
- NCT03368352
- Testing
- Melatonin, Hypoxia
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
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