Clinical trials: Cognitive Deficits
Mild Cognitive Impairment
Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1
Project 1: The goal of this research project is to examine usability and acceptance of virtual reality (VR) applications and their efficacy with older adults.
- Trial name
- NCT05811338
- Testing
- Project 1 - Phase 2: VR Program for Social, Activity, and Cognitive Engagement, Project 1 - Phase 2: Tablet for Social, Activity, and Cognitive Engagement
- Where
- 3 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Parkinson's Disease
Cognitive Rehabilitation in Parkinson's Disease
We are testing a computer game-style rehabilitation program for people with Parkinson's disease (PD). People with PD often have difficulty with motor planning, such as initiating or starting movements.
- Trial name
- NCT01085968
- Testing
- PC based training
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Mild Dementia
Gait Analysis by Induced Disorientation in a VR Environment
The aim of the study is to investigate whether the effect of disorientation on physical motion and gait among dementia patients, can be reliably measured in a laboratory environment, by means of a virtual reality (VR)…
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Disorientation, Young Adults
- Trial name
- NCT04134806
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Center Rostock
Post Operative Cognitive Dysfunction
Sugammadex and Cognitive Function
Post operative cognitive dysfunction (POCD) is recognized as a frequent complication after both cardiac and non cardiac surgery, affecting approximately 1/3 of the patients.
- Trial name
- NCT02419352
- Testing
- Sugammadex, Neostigmine/atropine
- Where
- Greece
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Cognitive Deficit in Attention, Musculoskeletal Strain
Effect of Surgeon Warm-up and Mental Visualisation During Robot-assisted Laparoscopic Surgery
Study Design - A Counterbalanced Study Aims - To determine the effect of a) warm-up exercises and b) mental visualisation on the musculoskeletal demands and cognitive demands respectively during robot-assisted laparoscopic…
- Conditions
- Cognitive Deficit in Attention, Musculoskeletal Strain, Fatigue, Surgery
- Trial name
- MURALS2 (NCT05884385)
- Testing
- Simulated exercises, Mental Visualisation
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Healthy Ageing, Cognitive Decline
Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.
This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function.
- Conditions
- Healthy Ageing, Cognitive Decline, Cardiorespiratory Fitness
- Trial name
- FAB (NCT07443189)
- Testing
- Home-Based HIIT
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Agder
Working Memory, Inhibitory Control
BID WM Digital Intervention in Aging
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1.
- Conditions
- Working Memory, Inhibitory Control, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT06918704
- Testing
- Coherence, Worder
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Auditory Perceptual Disorders, Aging Problems
Neuroplasticity in Auditory Aging_Project 2 Aims 1 and 2
Millions of elderly adults in the USA have age related hearing loss (ARHL), a malady that affects half of adults 60-69 years, and the majority of older adults.
- Trial name
- NCT03475043
- Testing
- Auditory training: temporal cues
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Dementia, Hearing Loss
Hearing Impairment as a Risk Factor for Dementia in Older Adults
This Doctor of Philosophy (PhD) project is part of a larger project on potentially modifiable risk factors for dementia in a life course perspective, with an overarching aim to improve prevention of dementia and thereby…
- Trial name
- NCT04284384
- Where
- Norway
- Volunteers
- 6,952 people, healthy volunteers welcome
- Sponsor
- Norwegian Centre for Ageing and Health
Cognitive Frailty
Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome
The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome…
- Trial name
- PCDS (NCT07335978)
- Testing
- Intervention 1
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Atma Jaya Catholic University of Indonesia
Cognitive Impairment, Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment
Long-term cognitive dysfunction greatly influences patient's quality of life after critical illness. However,its neurophysiological basis remains unknown.This is a 3 year fMRI study conducted at the Jiangyin people's Hospital.
- Conditions
- Cognitive Impairment, Functional Magnetic Resonance Imaging, Septic Shock, Inflammation
- Trial name
- NCT03946839
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jian-jun Yang
Huntington Disease
Study to Assess the Safety, Tolerability and Pharmacokinetic Profile of PBF-999 "After Multiple Oral Doses" in Healthy Volunteers
To assess the safety and tolerability of five doses of PBF-999 (160 mg and 320mg) after repeated (8 days) single daily oral dose administration in young male and female healthy subjects.
- Trial name
- NCT02907294
- Testing
- PBF-999 / 160 mg, PBF-999 / 320 mg
- Where
- Spain
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Palobiofarma SL
Postoperative Cognitive Dysfunction, Mild Cognitive Impairment
Postoperative Cognitive Decline, Inflammation, and Plasma Levels of Beta-amyloids
Postoperative cognitive dysfunction (POCD) can be a serious complication. The development of therapeutic strategies for the prevention and treatment of this condition requires the identification of subgroup of patients with the…
- Trial name
- NCT00850928
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Driving Impaired, Cognitive Impairment
Dose-response of Cannabis and Driving
Epidemiological studies have established a link between collisions while driving and cannabis use. With the changing legal landscape around cannabis, there is much interest in determining per se limits of cannabis while driving.
- Conditions
- Driving Impaired, Cognitive Impairment, Abuse Cannabis
- Trial name
- NCT03656029
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Patients With Severe Mental Illness
Cognitive Impairment Characteristics and Biological Mechanisms in Untreated Severe Mental Illness
Patients with Severe Mental Illness (SMI) frequently exhibit cognitive impairment of varying degrees, involving multiple cognitive domains.
- Trial name
- NCT07448675
- Where
- China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research
Alzheimer Disease, Dementia
OCT Angiography and NRAI in Dementia
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT03761381
- Testing
- Optical Coherence Tomography Angiography (OCTA) Imaging, Noninvasive Retinal Amyloid Imaging (NRAI)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Age-related Cognitive Decline
Train the Brain With Music: Brain Plasticity and Cognitive Benefits Induced by Musical Practice in Elderly People
This longitudinal study aims to countervail age-related cognitive and cerebral decline in healthy retired people through intensive piano / keyboard music practice in Switzerland and Germany.
- Trial name
- TBM (NCT03674931)
- Testing
- musical practice, music education
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- School of Health Sciences Geneva
Insomnia, ADHD
CBT-I in Adolescents With ADHD
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity, affecting individuals across the lifespan.
- Trial name
- NCT07209969
- Testing
- CBT-I group
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cognitive Impairment, Healthy Control
Prediction of MMSE Scores for Cognitive Impairment
This study aims to explore the potential of using machine learning (ML) algorithms to predict cognitive status, specifically MMSE scores, based on oral health and demographic data.
- Trial name
- NCT06611475
- Testing
- MMSE ≤26
- Where
- Sweden
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
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