Clinical trials: Cognitive Deficits
Cognitive Dysfunction, Postoperative Delirium
Electroencephalographic Biomarker to Predict Acute Post-operatory Cognitive Dysfunction
Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients after surgery. Two acute cognitive dysfunctions have been described: postoperative delirium (PD) and postoperative…
- Trial name
- NCT04214496
- Testing
- Sedline
- Where
- 2 sites in Chile
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Chile
Chinese Acupuncture
Chinese Acupuncture for Chemobrain in Elderly Cancer Patients
Elderly cancer patients would suffer cognitive impairment due to chemotherapy, and a series of neurocognitive symptoms, known as "chemobrain".
- Trial name
- NCT05876988
- Testing
- Chinese acupuncture
- Where
- China
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Musculoskeletal Pain, Musculoskeletal Strain
Surgeon Ergonomics in Robotic-assisted Laparoscopic Vs Standard Laparoscopic Surgery
Musculoskeletal injuries amongst surgeons are prevalent. This project will determine whether Robotic-assisted Laparoscopic surgery (RALS) offers superior benefits to surgeon's musculoskeletal health than standard laparoscopic…
- Conditions
- Musculoskeletal Pain, Musculoskeletal Strain, Fatigue; Muscle, Heart, Cognitive Impairment
- Trial name
- MURALS (NCT04477746)
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Mild Cognitive Impairment
Protein and microRNA Markers for Early Detection of Alzheimer's Disease
Blood will be harvested from three groups of people, normal control, patients with mild cognitive impairment (MCI) and patients with Alzheimer's disease (AD), 20 people per group.
- Trial name
- NCT03388242
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Healthy Aging, Alzheimer's Disease
The Feasibility, Safety and Tolerability of VR-based Audiovisual Stimulation
This single-session, within-subject, sham-controlled early feasibility study evaluated the safety, tolerability, and feasibility of delivering 40 Hz audiovisual (gamma sensory) stimulation through a virtual reality (VR) headset…
- Conditions
- Healthy Aging, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- CFS (NCT06234930)
- Testing
- Audiovisual stimulation VR system
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Clarity Health Technologies, Inc
HIV/AIDS, Aging
Psychosocial Intervention for Older HIV+ Adults With HAND
CTNPT 029 will test the feasibility and acceptability of cognitive remediation group therapy in older adults living with HIV who have been diagnosed with HIV-associated neurocognitive disorder (HAND).
- Conditions
- HIV/AIDS, Aging, Mild Cognitive Impairment, Group, Peer
- Trial name
- IN-HAND (NCT03483740)
- Testing
- CRGT, HIV group therapy
- Where
- 3 sites in Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Post-Operative Confusion, Neuroinflammatory Response
Neuroinflammation and Alzheimer's Pathology in POCD
The purpose of this project is to investigate the role of both neural inflammation and pre-existing neurodegenerative pathology in the risk and pathogenesis of post-operative cognitive dysfunction (POCD).
- Conditions
- Post-Operative Confusion, Neuroinflammatory Response, Alzheimer Disease
- Trial name
- POCD (NCT05378659)
- Testing
- Montreal Cognitive Assessment, Stroop Test, 4AT Delirium
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Multiple Sclerosis, Healthy
Effects of Gilenya (Fingolimod) on Thalamus Pathology and Cognitive Impairment in Patients With Relapsing Forms of Multiple Sclerosis
This study aims to assess the effect of Gilenya on brain pathology and cognitive impairment over 6, 12, and 24 months in patients with relapsing MS using MRI, clinical data, and neurological assessments.
- Trial name
- GLT (NCT02021162)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Attention Deficit Hyperactivity Disorder
Cognitive Behavioral Therapy for Adolescents With Attention-Deficit / Hyperactivity Disorder
Attention Deficit/ Hyperactivity Disorder (ADHD) is a common childhood psychiatric condition, which often persists into adolescence.
- Trial name
- NCT02566824
- Testing
- Cognitive Behavioural & Skills Training, Supportive Group Therapy, Treatment as Usual - community resources
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus, Type 2, Cognitive Dysfunction
Detection of Visual-Auditory Reaction Rates in Individuals With Type 2 Diabetes
Background: The primary purpose of our study was to understand the damage in the peripheral nerves of patients with diabetes and to determine the change in patients' reaction rates and perceptions by the age groups, duration of…
- Conditions
- Diabetes Mellitus, Type 2, Cognitive Dysfunction, Nerve Damage
- Trial name
- NCT05725889
- Testing
- recation time test
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Baskent University
Cognitive Dysfunction
Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs
The goal of this pilot work was to determine if the cognitive dysfunction accommodation strategies help patients retain/utilize more HIV prevention information and increase PrEP adherence.
- Trial name
- NCT05912374
- Testing
- standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB), enhanced Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Schizophrenia
The CAMPUS Project: Cholinergic Augmentation of Cognitive Deficits in Schizophrenia
The present study will specify and delineate the separate components of cognitive deficits and examine the effects of adjunctive cholinergic augmentation on these cognitive deficits as well as psychopathology in schizophrenic…
- Trial name
- NCT00206947
- Testing
- donepezil (5-10 mg/day)
- Where
- 4 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Birte Glenthoj
Cognitive Decline
Comparison of Three Motor-cognitive Training Programs
Understanding how to delay age-related physical and mental declines is an issue for aging research. It has been shown that isolated aerobic, coordination and cognitive training improve brain functions and cognitive performances.
- Trial name
- EXECO (NCT04504643)
- Testing
- Technology-assisted circuit training, Conventional circuit training, Nordic walking
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Aix Marseille Université
Gait Apraxia, Alzheimer Disease
Gait and Alzheimer Interaction Tracking (GAIT) Study
The purpose of this study is to examine and to compare gait characteristics under single- and dual-task conditions among healthy subjects together with AD patients at different stages of disease (i.e., pre-dementia, mild and…
- Conditions
- Gait Apraxia, Alzheimer Disease, Impaired Cognition, Cerebral Atrophy
- Trial name
- GAIT (NCT01315717)
- Where
- France
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Aging, Cognitive Aging
Music Improvisation Training on Cognitive Function in Older Adults
This project will study the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI.
- Conditions
- Aging, Cognitive Aging, Cognitive Impairment, Cognitive Training
- Trial name
- Music Training (NCT06721390)
- Testing
- Piano Improvisation, Music Listening
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Age-related Cognitive Decline
The Dortmund Vital Study: Impact of Biological and Lifestyle Factors on Cognitive Performace and Work Ability
The goal of the Dortmund Vital Study is to validate previous hypotheses and to generate and validate new hypotheses about the relationship of ageing, working conditions, genetic makeup, stress, metabolic functions, cardiovascular…
- Trial name
- DVS (NCT05155397)
- Where
- Germany
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Technical University of Dortmund
Post-stroke Dementia, Vascular Mild Cognitive Impairment
The Aging Brain and Cognition: Contribution of Vascular Injury, Amyloid Plaque and Tau Protein to Cognitive Dysfunction After Stroke
Stroke can lead to signficiant neurological deficits, and about one-third of stroke patients will be diagnosed of vascular mild cognitive impairment or post-stroke dementia.
- Trial name
- NCT04588649
- Testing
- THK-5351, AV-45
- Where
- Taiwan
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Central Nervous System Complications of Anesthesia, Impaired Cognition
Exposure to General Anaesthesia in Infancy and Neurocognitive Development
This prospective cohort study aims to determine if apparently healthy children with no significant co-morbidities who undergo general anaesthesia for minor surgery before 15 months of age will develop measurable deficits in…
- Trial name
- EGAIN (NCT02182817)
- Where
- 2 sites in Singapore
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Brain Damage, Chronic
The Effect of tDCS on Subcortical Brain Functioning
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain abilities related to cognition, emotion and/or physical functioning in individuals with subcortical brain damage.
- Trial name
- NCT01602276
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
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