Clinical trials: Cognitive Deficits
Mild Cognitive Impairment
Investigating the Efficacy of Ergothioneine to Delay Cognitive Decline (Pilot)
With the growing burden of dementia (including Alzheimer's disease), and the lack of efficacious therapies, there is an urgent need to identify new therapeutics.
- Trial name
- NCT03641404
- Testing
- L-ergothioneine
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Mild Cognitive Impairment
Digital Tools to Support Healthcare Decision Making
The goal for this project is to support the cognitive components of older adults' health-management activities through development of digital assistant technology tools tailored to three exemplar healthcare management task…
- Trial name
- CREATE P3 (NCT07485725)
- Testing
- Project 3, Phase 2: Clinical Trial
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer Disease, Frontotemporal Degeneration
In Vivo PET of Synaptic Density in Cognitive Disorders
This study will compare the discriminative power of [18F]-SynVesT-1 PET and the standard-of-care [18F]-FDG PET in different cognitive disorders (Alzheimer's disease, Frontotemporal degeneration, dementia with Lewy bodies and…
- Conditions
- Alzheimer Disease, Frontotemporal Degeneration, Dementia With Lewy Bodies, Psychiatric Disorder
- Trial name
- NCT05384353
- Testing
- [18F]-SynVesT-1
- Where
- Belgium
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Healthy
Do Apolipoprotein E Polymorphisms Influence Risk of Cognitive Decline by Modulating Omega-3 Fatty Acid Metabolism?
BACKGROUND: Compared to the epsilon 2 or epsilon 3 alleles, the epsilon 4 allele of apolipoprotein E (ApoE4) is associated with twice the prevalence of late-onset Alzheimer's disease (AD).
- Trial name
- NCT01577004
- Testing
- omega-3 fatty acid
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Mild Cognitive Impairment
Multidisciplinary Intervention for Mild Cognitive Impairment
The purpose of this investigation is to conduct a series of case studies on the impact of a novel functional medicine approach to improving cognitive skills, brain structure, and daily functioning for participants with Mild…
- Trial name
- (MCI) (NCT02943187)
- Testing
- Cognitive training, Nutrition
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Gibson Institute of Cognitive Research
ADHD, Attention Deficit Hyperactivity Disorder
Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD
The purpose of the study is to examine the developmental trajectory of response control in boys and girls with ADHD entering adolescence.
- Trial name
- NCT05927506
- Testing
- Other
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stroke, Brain Diseases
VIrtual Reality Glasses Use to Improve Lateropulsion and the Post-stroke Postural Vertical
VIRGIL is a monocentric interventional study aiming to investigate the effect of immersion in a virtual tilted room on modulation of the verticality representation (postural vertical [PV] and visual vertical [VV]), which in turn…
- Conditions
- Stroke, Brain Diseases, Cerebrovascular Disorders, Postural; Defect
- Trial name
- VIRGIL (NCT04911738)
- Testing
- Virtual Reality , immersion in a virtual titlted room
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Alzheimer Disease, Mild Cognitive Impairment
LEADing Dementia End-of-Life Planning Conversations
Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer's disease or related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated…
- Trial name
- LEAD (NCT05909189)
- Testing
- LEADing Dementia End-of-Life Planning Conversations
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Apathy, Mild Cognitive Impairment
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
Apathy, a profound loss of initiative and motivation, is often seen in older Veterans with memory problems. Apathy leads to serious health problems, increases dependency, and caregiver burden.
- Conditions
- Apathy, Mild Cognitive Impairment, Transcranial Magnetic Stimulation, Loneliness
- Trial name
- TAMCI (NCT03590327)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Randomized Controlled Trial
Cognitive Stimulation in Older With Mild Cognitive Impairment
The participants who carry out our program of cognitive stimulation, deteriorate at a cognitive level more slowly and can improve their score of the Spanish version of 35 points of Mini-mental State of Folstein; Mini-exam…
- Trial name
- Cognitive (NCT03831061)
- Testing
- Cognitive stimulation
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Attention Deficit Disorder With Hyperactivity
Extra Time on Brazilian College Level Exam for Students With and Without ADHD
Standardized tests such as the Scholastic Aptitude Test (SAT) and the brazilian National High School Exam (ENEM) give more time for students with Attention Deficit and Hyperactivity Disorders (ADHD) to complete the exam.
- Trial name
- NCT06063382
- Testing
- Extended time 25%, Extended time 50%
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Morbidity of Primary Open Angle Glaucoma
Matching Glaucoma With Impaired Cognition
Glaucoma is the leading cause of irreversible blindness in the world. The current study is designed to find the underlying relationship between impairment of topological perception and incidence of glaucoma.
- Trial name
- MAGIC (NCT03695224)
- Testing
- Topological perception test
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment
Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects
The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.
- Conditions
- Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- PRESAGE (NCT05640141)
- Testing
- MRI evaluation, Actimetry & IMU, Gait evaluation
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Mild Cognitive Impairment
Evolving Methods to Combine Cognitive and Physical Training for Individuals With Mild Cognitive Impairment
This study aims to investigate and compare the intervention effects of combining exercise and cognitive training (either sequentially or simultaneously in a dual-task paradigm) in elderly with mild cognitive impairment.
- Trial name
- NCT02512627
- Testing
- Cognitive training, Physical exercise
- Where
- 9 sites in Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Exercise Environment and Cognitive Performance in Older Adults
Outdoor vs. Indoor Exercises and Cognitive Functions in Older Adults
This observational, cross-sectional study aims to comparatively investigate the effects of outdoor versus indoor exercise environments on overall cognitive performance and its specific sub-domains (attention, memory, and…
- Trial name
- NCT07728786
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Huntington Disease
Benchmarking Integrated Care for People Living With Huntington's Disease in England
The survey and full study information can be accessed here: https://southampton.qualtrics.com/jfe/form/SV_8iEedDJZy4xaiI6 The goal of this anonymous survey is to benchmark integrated care from the perspective of service users in…
- Trial name
- Integrate-HD (NCT05828992)
- Testing
- No intervention administered
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Healthy, Subjective Cognitive Decline (SCD)
Sleep Stimulation to Enhance Waste Clearance in the Brain
This study aims to examine whether multi-night closed-loop auditory stimulation (CLAS) during sleep can enhance waste clearance and memory consolidation in healthy adults and older adults with subjective cognitive decline or mild…
- Conditions
- Healthy, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
- Trial name
- NCT07051239
- Testing
- Closed-loop acoustic stimulation
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Mild Cognitive Impairment
iTBS rTMS in Mild Cognitive Impairment
The purposes of this research are to test whether it is feasible to administer a treatment protocol called intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS) in adults with mild…
- Trial name
- NCT05327257
- Testing
- iTBS rTMS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maria I. Lapid, M.D.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.