Clinical trials: Cognitive Delay, Mild
Alzheimer Disease
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
The primary purpose of this study is to evaluate the safety and tolerability of Zunveyl® over 12 weeks of routine clinical use in adults with mild to moderate Alzheimer's disease.
- Trial name
- RESOLVE (NCT07633470)
- Testing
- Zunveyl®
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Alpha Cognition, Inc
Alzheimer Disease, Cognition Disorders
Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx)
This phase IIIb trial is a prospective, randomized, double-blind, placebo-controlled, 36-month study comparing the length of time of progression from mild cognitive impairment (MCI) to a clinical diagnosis of Alzheimer's disease…
- Trial name
- NCT00000174
- Testing
- Rivastigmine
- Where
- 15 sites in United States
- Sponsor
- Novartis
Mild Cognitive Impairment Due to Alzheimer's Disease
Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset
The purpose of this study is to qualify the biomarker risk algorithm for prognosis of the risk of developing Mild Cognitive Impairment due to Alzheimer's Disease (MCI-AD), and also to evaluate the efficacy of pioglitazone…
- Trial name
- TOMMORROW (NCT01931566)
- Testing
- Pioglitazone
- Where
- 55 sites in United States, Australia and 3 more
- Volunteers
- 3,494 people, healthy volunteers welcome
- Sponsor
- Takeda
Shwachman-Diamond Syndrome, SDS
Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform
The Shwachman-Diamond Syndrome Global Patient Survey and Collaboration Program (SDS-GPS) is an opportunity for patients and their families - from anywhere in the world - to share their experience living with SDS via a safe…
- Conditions
- Shwachman-Diamond Syndrome, SDS, IBMF, Congenital Neutropenia
- Trial name
- SDS-GPS (NCT06999954)
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Shwachman-Diamond Syndrome Alliance Inc
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Mild Cognitive Impairment
Cognitive Activation Therapy for MCI: A Randomized Control Study
Mild cognitive impairment (MCI) describes an initial phase of cognitive decline, usually among older adults, in which a person notices a decline in attention or memory, and performs worse than normal on cognitive tests of such.
- Trial name
- FarbMCI2012 (NCT01641328)
- Testing
- Cogntive Activation Training, Waitlist Control / Home-based training
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Rotman Research Institute at Baycrest
Mild Cognitive Impairment
ThinkingFit: Combined Physical, Cognitive and Social Treatment in Mild Cognitive Impairment (MCI)
Dementia is serious problem and around 700 000 people are affected in the UK alone. Currently there is no cure however early diagnosis and effective treatment offers hope for reducing the impact.
- Trial name
- ThinkingFit (NCT01603862)
- Testing
- ThinkingFit programme
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- Dr Thomas Dannhauser
Alzheimer Disease
Memory Impairment Study (Mild Cognitive Impairment Study)
The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia.
- Trial name
- NCT00000173
- Testing
- Donepezil, Vitamin E
- Where
- 72 sites in United States, Canada
- Sponsor
- National Institute on Aging (NIA)
Mild Cognitive Impairment, Mild Alzheimer's Disease
A Novel Therapeutic Target for Alzheimer's Disease in Men and Women 50-85 Years of Age.
A randomized-control, double-blind, multi-center, delayed-start, pilot trial evaluating the disease modifying effects of a 150mg once-a-day dose vs.
- Trial name
- NCT03752294
- Testing
- Dabigatran
- Sponsor
- University of Rhode Island
Mild Cognitive Impairment, Mild Dementia
Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia
This study will adopt a newly developed computer-based cognitive rehabilitation program targeting the encoding stage of memory. The aims of the study are: 1.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Healthy Older Adults
- Trial name
- NCT03430401
- Testing
- Perceptual-based memory encoding, Semantic-based memory encoding, Cognitive stimulation
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Western Sydney
Mild Cognitive Impairment, Prodromal Alzheimer's Disease
Deferiprone to Delay Dementia (The 3D Study)
This study is a phase 2, randomised, placebo-controlled, multicentre study to investigate the safety and efficacy of Deferiprone in participants with Prodromal Alzheimer's Disease (pAD) and Mild Alzheimer's Disease (mAD).
- Conditions
- Mild Cognitive Impairment, Prodromal Alzheimer's Disease, Mild Alzheimer's Disease
- Trial name
- NCT03234686
- Testing
- Deferiprone 600mg delayed release tablets
- Where
- 8 sites in Australia
- Volunteers
- 81 people
- Sponsor
- Neuroscience Trials Australia
Cerebral Palsy, Infant Development
Associations Between General Movements Assessments and Cognitive Development
High risk infant is defined as infant with a negative history of environmental and biological factors, which can lead to neuromotor development problems.
- Conditions
- Cerebral Palsy, Infant Development, Cognitive Dysfunction, Cognitive Developmental Delay
- Trial name
- GMs (NCT05217056)
- Testing
- measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Mild Cognitive Impairment, Memory Disorders
Behavioral Interventions to Prevent or Delay Dementia
This study will compare the effectiveness of different combinations of 5 types of behavioral interventions across patient-centered outcomes. It will also evaluate which outcomes (e.g.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Mild Dementia, Impaired Cognition
- Trial name
- NCT02265757
- Testing
- Cognitive Rehabilitation, Computer Brain Fitness Training, Support Group (patient and partner)
- Where
- 3 sites in United States
- Volunteers
- 272 people
- Sponsor
- Mayo Clinic
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Mild Cognitive Impairment
Investigating the Efficacy of Ergothioneine to Delay Cognitive Decline (Pilot)
With the growing burden of dementia (including Alzheimer's disease), and the lack of efficacious therapies, there is an urgent need to identify new therapeutics.
- Trial name
- NCT03641404
- Testing
- L-ergothioneine
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Dementia, Cognitive Change
MIND Diet to Improve Cognitive Function in Mild Stroke Patients
A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on the rate of cognitive change…
- Conditions
- Dementia, Cognitive Change, Stroke, Cerebral Infarction
- Trial name
- MINDICOMS (NCT05921084)
- Testing
- MIND diet intervention, General dietary advice
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
Mild Cognitive Impairment, Cognitive Change
Conversations as a Means to Delay the Onset of Alzheimer's Disease
Past epidemiological studies have demonstrated that larger social networks, or more frequent social interactions, could have potential protective effects on the incidence of Alzheimer's Disease (AD).
- Trial name
- conversation (NCT01571427)
- Testing
- Active social engagement group, Control group
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Alzheimer's Disease
A Study of Lanabecestat (LY3314814) in Participants With Mild Alzheimer's Disease Dementia
The main purpose of this study is to evaluate the efficacy of the study drug known as lanabecestat in participants with mild Alzheimer's disease (AD) dementia.
- Trial name
- DAYBREAK-ALZ (NCT02783573)
- Testing
- Lanabecestat
- Where
- 262 sites in United States, Canada and 16 more
- Volunteers
- 1,722 people
- Sponsor
- AstraZeneca
Vitamin D Deficiency, Musculoskeletal Diseases
Vitamin D in School Children
The primary purpose of this study it to investigate total circulating 25-hydroxyvitamin D (25(OH)D) in school children (aged 4-11years) in Northern Ireland; thereby establishing the prevalence of vitamin D status (deficiency…
- Conditions
- Vitamin D Deficiency, Musculoskeletal Diseases, Cognitive Delay, Mild
- Trial name
- DVinCHI (NCT05018988)
- Testing
- Oral vitamin D spray
- Where
- United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Age-related Cognitive Decline, Mild Cognitive Impairment
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown.
- Conditions
- Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT04171323
- Testing
- Cognitive Training, Computerized Cognitive Stimulation
- Where
- 6 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- University of Alabama at Birmingham