Clinical trials: Cognitive Deterioration
Multiple Sclerosis
GTA-MEG as a Biomarker for Cognition in MS
In this study, 100 persons with Multiple Sclerosis and 50 matched controls will be examined with magnetoencephalography (MEG), magnetic resonance imaging (MRI) and cognitive tests.
- Trial name
- NCT02851342
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Cognitive Impairment, Cognitive Decline
Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom
- Trial name
- MoCA-Norm (NCT03246269)
- Testing
- MoCA
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Andreas Monsch
Hypobaric Hypoxia, Cognitive Deterioration
Effects of Acute Hypobaric Hypoxia Exposure on Neurocognitive Performance of Pre-hospital Emergency Service Providers
The study aims to evaluate the effects of acute hypobaric hypoxia on cognitive performance (H0: cognitive performance at 200 meters above sea level (asl) = cognitive performance at 3000 meters above sea level = cognitive…
- Conditions
- Hypobaric Hypoxia, Cognitive Deterioration, Emergency Medicine, Resuscitation
- Trial name
- NCT04138446
- Testing
- Altitude exposure in climate chamber
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Mild Cognitive Impairment, Mild Dementia
Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia
This study will adopt a newly developed computer-based cognitive rehabilitation program targeting the encoding stage of memory. The aims of the study are: 1.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Healthy Older Adults
- Trial name
- NCT03430401
- Testing
- Perceptual-based memory encoding, Semantic-based memory encoding, Cognitive stimulation
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Western Sydney
Clinical Deterioration
Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults
The goal of this clinical trial is to determine whether a multicomponent exercise program improves functional capacity and cognitive status in hospitalized elderly patients aged 75 and older.
- Trial name
- PREDISC (NCT06634147)
- Testing
- Exercise
- Where
- 2 sites in Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Alzheimer Disease, Mild Cognitive Impairment
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Electrical activity in the brain known as "gamma" brainwaves help connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia, Cognition Disorders in Old Age
- Trial name
- AlzLife (NCT03657745)
- Testing
- Combination of 40Hz light and cognitive therapy (ALZLIFE)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Light LLC
Cognitive Deterioration, Disorder of Aging
Exercise, Age-Related Memory Decline, And Hippocampal Function
The purpose of this study is to test the hypothesis that aerobic exercise leads increased cerebral blood volume in the dentate gyrus of the hippocampus in a sample of young and older adults.
- Trial name
- NCT01329653
- Testing
- aerobic training, Wait list
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Age-related Cognitive Decline, Cognitive Deterioration
Decoding the Cognitive Trajectory of Hong Kong SuperAgers: a Longitudinal Follow-up Study
This is a prospective follow-up study conducted at the Department of Psychiatry, The Chinese University of Hong Kong. The participants, including high-performing elderly (SuperAgers), normal ageing elderly and neurocognitive…
- Conditions
- Age-related Cognitive Decline, Cognitive Deterioration, Dementia, Mild
- Trial name
- NCT05728801
- Testing
- Ageing
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cognitive Change, Cognitive Decline
Normative Database and Test-Retest Reliability for BrainCheck Assessments
The purpose of this study is to collect normative test values and demographic information for normative and referential data for a rapid, portable, computerized neurocognitive testing device from healthy adults 50 and older.
- Conditions
- Cognitive Change, Cognitive Decline, Cognitive Deterioration, Neurocognitive Deficit
- Trial name
- NDTR (NCT05497427)
- Testing
- BrainCheck Assessment
- Where
- 5 sites in United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Menopause, Perimenopausal Disorder
Virtual perI-/Menopause Registry of AusTrALia
13 million (50.7%) Australians are born with ovaries, 14% (~3 million) are currently aged 40-59 yrs, \& all such who live to midlife will experience menopause, defined as >12 months without a period.
- Conditions
- Menopause, Perimenopausal Disorder, Postmenopausal Symptoms, Health Knowledge, Attitudes, Practice
- Trial name
- VITAL (NCT06487130)
- Testing
- N/A Observational Registry
- Where
- Australia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Bespoke Clinical Research