Clinical trials: Cognitive Disorder
Hunter Syndrome
Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment
Study HGT-HIT-094 is a multicenter study designed to determine the effect on clinical parameters of neurodevelopmental status of monthly IT administration of idursulfase-IT 10 mg for 12 months in pediatric patients with Hunter…
- Trial name
- AIM-IT (NCT02055118)
- Testing
- idursulfase-IT, No IT treatment
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 58 people
- Sponsor
- Shire
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms
The objective of this study is to identify Acute Coronary Syndromes (ACS) patients' specific needs and preferences for depression treatment via in-person or virtual individual interviews to (a) guide MBCT adaptation; and identify…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT03878160
- Testing
- Individual Interview
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment, Cognitive Decline
Brain Health Together: A Live-Streaming Group-Based Digital Program
The purpose of this study is to develop and test a comprehensive Brain Health Together program for older adults living with cognitive decline.
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Cognitive Deterioration, Cognitive Deficits, Mild
- Trial name
- NCT05818423
- Testing
- Brain Health Academy, Brain Health Together, Maintain Brain Health Together
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of California, San Francisco
Generalized Anxiety Disorder
Telephone Psychotherapy for Late-Life Generalized Anxiety Disorder (GAD)
The purpose of this study is to determine if cognitive-behavioral therapy (CBT)and supportive therapy delivered by telephone are effective for reducing worry and anxiety in rural older adults with Generalized Anxiety Disorder…
- Trial name
- NCT01259596
- Testing
- cognitive behavioral therapy, nondirective supportive therapy
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer, Gynecologic Cancer
Evaluating Smoking Cessation Protocols in Cancer Patients: NRT, MI, CBT or Hypnotherapy
This trial offers support and assistance to patients wishing to quit smoking in order to increase the success rate of smoking cessation and all the benefits associated with it.
- Conditions
- Breast Cancer, Gynecologic Cancer, Digestive Cancer, Melanoma
- Trial name
- RESPIRE (NCT04899492)
- Testing
- Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT), Hypnotherapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Institut Cancerologie de l'Ouest
Posttraumatic Stress Disorder
Assessment and Treatment of Cognitive Functioning Deficits in Veterans With PTSD
Approximately half a million Veterans receiving services at the VA have Posttraumatic Stress Disorder (PTSD). PTSD is strongly associated with cognitive functioning deficits in areas of concentration, attention, memory, learning…
- Trial name
- CCTPTSD (NCT03696225)
- Testing
- Compensatory Cognitive Training (CCT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Marijuana Abuse
The Effect of Food on the Oral Bioavailability of AEF0117 in Healthy Volunteers
Cannabis use is increasing and will only further escalate with legalization of recreational and medical cannabis use in western countries , with a prevalence greater than 30 % in the US and most European countries for individuals…
- Trial name
- NCT05451017
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fed condition, 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fasting condition
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aelis Farma
Multiple Sclerosis, Cognitive Impairment
Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT
Cognitive impairment is highly prevalent, poorly-managed, and disabling in persons with MS and exercise training might represent a promising approach to manage this symptom of the disease.
- Trial name
- NCT03677440
- Testing
- Treadmill Walking Exercise Training, Stretching-and-Toning Exercise Training
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Kessler Foundation
Brain Tumor
Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
Primary Objective: To assess the efficacy of immediate release methylphenidate, sustained release methylphenidate, and the novel vigilance enhancing drug modafinil for the improvement of cognitive functioning in patients with…
- Trial name
- NCT00418691
- Testing
- IR Methylphenidate, Modafinil, SR Methylphenidate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Cognitive Function Abnormal
Boost Study 21270 (Cognition)
This study is designed to to test the technical feasibility of encouraging interaction with a mobile smartphone software package (mHealth app) for training aspects of executive function and cognition.
- Trial name
- NCT05990335
- Testing
- mHealth application (custom)
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- NXTech
Agitation Associated With, Alzheimer's Disease
A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation
To compare the efficacy of 2 fixed doses of brexpiprazole with placebo in participants with agitation associated with dementia of the Alzheimer's type.
- Conditions
- Agitation Associated With, Alzheimer's Disease, Alzheimer's Type, Mental Disorder
- Trial name
- NCT01862640
- Testing
- Brexpiprazole, OPC-34712
- Where
- 85 sites in United States, Croatia and 5 more
- Volunteers
- 433 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar Disorder
Bipolar Transcranial Alternating Current Stimulation (tACS)
The purpose of this clinical trial is to measure the safety and effectiveness of a non-invasive brain stimulation device called Transcranial Alternating Current Stimulation (tACS) in participants with bipolar disorder (BD).
- Trial name
- NCT05480124
- Testing
- tACS brain stimulation treatment
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Michigan
Dementia, Mild Cognitive Impairment
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
This study aims to develop, evaluate, and commercialize an in-home supportive technology that is designed to alleviate anxiety, burden, and loneliness in spousal and familial caregivers of individuals with Alzheimer's disease…
- Conditions
- Dementia, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT05159583
- Testing
- In-Home Technology System, Limited In-Home Technology
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Cognitive Impairment
SHARE: Sharing Healthcare Wishes in Primary Care
This study evaluates the efficacy of Sharing Healthcare Wishes in Primary Care (SHARE), a two-group randomized trial at up to 9 primary care practices in which 124 dyads receive a control protocol of minimally enhanced usual care…
- Trial name
- NCT04593472
- Testing
- Sharing Healthcare Wishes in Primary Care (SHARE), Minimally Enhanced Usual Care
- Where
- 9 sites in United States
- Volunteers
- 273 people
- Sponsor
- Johns Hopkins University
Huntington Chorea
Efficacy and Safety on SOM3355 in Huntington's Disease Chorea
Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington's Disease with choreic movements.
- Trial name
- NCT05475483
- Testing
- SOM3355 200 mg capsules, SOM3355 300 mg capsules
- Where
- 23 sites in France, Germany and 5 more
- Volunteers
- 139 people
- Sponsor
- SOM Innovation Biotech SA
Caregiver Stress
Mindfulness-based Cognitive Coping for ADRD Caregivers
This project will evaluate the effectiveness of the Mindfulness-based Cognitive Coping (MCC) intervention to alleviate stress and depressive symptoms of caregivers of Individuals with Alzheimer's Disease and Related Dementia.
- Trial name
- NCT05979922
- Testing
- Mindfulness-based Cognitive Coping, Traditional Educational/Resources Program
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Photozig, Inc.
Drug Dependence, Alcohol Dependence
Impact of Exercise and Affirmations (IntenSati) on Addiction-related Cognitive and Psychosocial Deficits
Addiction to illicit and prescribed drugs, alcohol and tobacco is associated with a panoply of brain changes that contribute to structural and micro-structural deficits, altered metabolism and neurotransmission, and related…
- Trial name
- NCT01171677
- Testing
- IntenSati
- Volunteers
- 40 people
- Sponsor
- NYU Langone Health
Subjective Memory Loss in Older Persons
Study of the Effects of Cerefolin NAC on Inflammation Blood Markers in Older Individuals With Memory Complaints
The purpose of this six-month research study is to determine if Cerefolin NAC reduces levels of substances in the blood that may be associated with thinking ability and the health of brain cells in subjects with memory concerns…
- Trial name
- NCT00597376
- Testing
- Cerefolin NAC (a medical food)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Rush University Medical Center
Mild Cognitive Impairment
Effect of Action Observation Training on Gait Variables and Global Cognitive Functions
This study will investigate the effect of Action Observation Teaining (AOT) on gait variables and global cognitive functions in older adults with mild cognitive impairment (MCI).
- Trial name
- NCT03522389
- Testing
- AOT with gait training, Gait training, Education
- Where
- Thailand
- Volunteers
- 39 people
- Sponsor
- Mahidol University
Multiple Sclerosis, Cognition
Lipoic Acid and Omega-3 Fatty Acids for Cognitive Impairment in Multiple Sclerosis
The primary aim is to collect data to determine the correct effect size on the primary outcome to aid in the design of a larger study: The primary outcome is to determine if lipoic acid and omega-3 fatty acids can improve…
- Trial name
- NCT02133664
- Testing
- lipoic acid and omega-3 fatty acids
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Oregon Health and Science University
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