Clinical trials: Cognitive Disorder
Urologic Chronic Pelvic Pain Syndrome (UCPPS), Interstitial Cystitis
EPPIC: Easing Pelvic Pain Interventions Clinical Research Program
The EPPIC (Easing Pelvic Pain Interventions Clinical Research Program) study evaluates an ultra-brief, 4 session cognitive behavioral pain treatment transdiagnostic in design for urologic chronic pain syndrome (UCPPS) with…
- Conditions
- Urologic Chronic Pelvic Pain Syndrome (UCPPS), Interstitial Cystitis, Bladder Pain Syndrome, Chronic Prostatitis
- Trial name
- EPPIC (NCT05127616)
- Testing
- Minimal Contact-Cognitive Behavior Therapy, Patient Education/Support
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- State University of New York at Buffalo
Schizophrenia, Cognition
Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia
The investigators propose to test whether curcumin nanoparticles will improve behavioral measures and biomarkers of cognition and neuroplasticity in patients with schizophrenia who are already receiving a stable dose of…
- Conditions
- Schizophrenia, Cognition, Psychosis
- Trial name
- NCT02104752
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Major Depressive Disorder
Comparison of Tianeptine Versus Escitalopram Patients Major Depressive Disorder
The primary object of this study is to confirm the superiority of tianeptine compared to escitalopram on effects that improves subjective and objective cognitive impairments in patients suffering from major depressive disorder.
- Trial name
- CAMPION (NCT01309776)
- Testing
- Tianeptine, Escitalopram
- Where
- 6 sites in South Korea
- Volunteers
- 164 people
- Sponsor
- Samsung Medical Center
Mild Cognitive Impairment, Insulin Resistance
Effect of a Modified Ketogenic-Mediterranean Diet on Alzheimer's Disease
The purpose of the BEAM study is to compare the effects of a low-carbohydrate diet and a lowfat diet for adults with mild memory loss and adults with pre-diabetes.
- Trial name
- BEAM (NCT02984540)
- Testing
- Low-Carbohydrate Diet, Low-Fat Diet
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Spinal Cord Injuries, Depression
Telepsychology in Spinal Cord Injury
This study will determine the effectiveness of tele-psychology in treating persons with spinal cord injury (SCI) with depressed mood in the early period post-rehabilitation discharge.
- Trial name
- NCT03711760
- Testing
- telepsychology
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Santa Clara Valley Health & Hospital System
Alzheimer's Disease
Deep Brain Stimulation for the Treatment of Alzheimer's Disease
The purpose of this clinical study is to investigate the safety and efficacy of deep brain stimulation (DBS)as a treatment option for patients with cognitive, behavioral, and functional disability of Alzheimer's disease.
- Trial name
- NCT01559220
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Ali Rezai, MD
Delirium and Post-operative Cognitive Dysfunction (POCD)
Cognitive Outcome After Two-stage Liver-Operation
Cognitive outcome (delirium and post-operative cognitive deficiency) in patients undergoing two-time liver resection.
- Trial name
- 2-StaLi (NCT01809782)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Huntington Disease
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 compared with placebo in participants with HD.
- Trial name
- NCT05358717
- Testing
- PTC518
- Where
- 28 sites in United States, Australia and 9 more
- Volunteers
- 159 people
- Sponsor
- Novartis Pharmaceuticals
Psychopathy
Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture
This clinical trial will examine whether transcranial magnetic stimulation (TMS), a noninvasive form of brain stimulation, can influence social cognition, cognitive processing, and brain function in adults with elevated…
- Trial name
- NCT07635940
- Testing
- continuous theta burst stimulation (cTBS), Intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Alzheimer's Disease, MCI Due to AD
Language, Speech and Motor Function in MCI Due to AD and Alzheimer's Disease
The goal of this observational cross-sectional study is to explore the characteristics of language, speech, and motor function in persons with Mild Cognitive Impairment due to Alzheimer's disease ("MCI due to AD") and persons…
- Conditions
- Alzheimer's Disease, MCI Due to AD, Dementia Alzheimers
- Trial name
- NCT06508268
- Testing
- GAITRite walkway system OR 4-meter walking speed test, Jamar hand dynamometer, Picture description task
- Where
- Netherlands
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Hanze University of Applied Sciences Groningen
Subarachnoid Aneurysm Hemorrhage
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Despite its lower incidence rate within the stroke population and tendency to affect younger individuals, SAH carries the highest risk of PSCI.
- Trial name
- NCT07588997
- Testing
- early motor-cognitive integrated training (e-MCIT), Early mobilization
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Taiwan University Hospital
Diabetes Type 1
Transition of T1DM Patients Aged Over 65 Years Into AHCL (780G) Insulin Pump
Older people with diabetes have a higher risk for cognitive impairment and for physical disability whether this may be effected by an improvement in glucose indices is unknown.
- Trial name
- 780G65+ (NCT06207838)
- Testing
- MiniMed 780G system
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Jagiellonian University
Mild Cognitive Impairment
A Comparative Study of Brain Structure and Amyloid Load in MCI Patients
Older people with DM are at greater risk of cognitive decline than their counterparts with DM. Cognitive impairment in older people with DM may be associated with non-AD related brain atrophy and white matter disease.
- Trial name
- NCT03773185
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Cerebral Small Vessel Disease
Correlation Between Deep Medullary Veins and Cognitive Dysfunction in Cerebral Small Vessel Disease
This study aims to obtain the characteristics of cognitive impairment and imaging characteristics of patients with Cerebral small vessel disease (CSVD) through comprehensive and standardized neuropsychological assessment and…
- Trial name
- NCT05715710
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zigong No.1 Peoples Hospital
Alzheimer's
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Alzheimer's Disease
This project explores Ginkgo biloba ester dispersible tablets influence on cognitive function in patients with mild-to-moderate elderly, to observe the effects of different intervention time on cognitive function, for alzheimer's…
- Trial name
- NCT03090516
- Testing
- Ginkgo biloba dispersible tablets, Donepezil, Ginkgo biloba dispersible tablets and Donepezil
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Complex Neurodevelopmental Disorder
Cognitive Benefit of Intensive Rehabilitation Using Rhythmic Music Training in Children With Complex Neurodevelopmental Disorder
In the wide range of studies carried out on neurodevelopmental disorders (NDD), rhythm disorders have been identified as a major cross-cutting component.
- Trial name
- CHUpercu (NCT07303049)
- Testing
- Intensive rhythmic musical training
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Toulouse
Creatine, Exercise
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function…
- Conditions
- Creatine, Exercise, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06948149
- Testing
- Creatine monohydrate, Resistance training
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Autism, Autism in Children
Developing a Novel Therapy for Aversive Sensory Experiences in Autism
The goal of this study is to assess whether a new psychological treatment can lead to changes in sensory experiences in autistic young people.
- Trial name
- NCT06682858
- Testing
- Group Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College London
Cognitive Deficit in Attention, Musculoskeletal Strain
Effect of Surgeon Warm-up and Mental Visualisation During Robot-assisted Laparoscopic Surgery
Study Design - A Counterbalanced Study Aims - To determine the effect of a) warm-up exercises and b) mental visualisation on the musculoskeletal demands and cognitive demands respectively during robot-assisted laparoscopic…
- Conditions
- Cognitive Deficit in Attention, Musculoskeletal Strain, Fatigue, Surgery
- Trial name
- MURALS2 (NCT05884385)
- Testing
- Simulated exercises, Mental Visualisation
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Agitation Associated With, Alzheimer's Disease
A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation
To compare the efficacy of 2 fixed doses of brexpiprazole with placebo in participants with agitation associated with dementia of the Alzheimer's type.
- Conditions
- Agitation Associated With, Alzheimer's Disease, Alzheimer's Type, Mental Disorder
- Trial name
- NCT01862640
- Testing
- Brexpiprazole, OPC-34712
- Where
- 85 sites in United States, Croatia and 5 more
- Volunteers
- 433 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
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