Clinical trials: Cognitive Disorder Patients and Cognitive Assessment
Delirium, Cognitive Dysfunction
Post-operative Delirium (POD) in Patients Undergoing Hip Fracture Surgery
The primary endpoint of the study is the appearance of Post Operative Delirium within the first 3 months. The secondary endpoints are the development of POCD, dementia of any type of new onset at 12 months, mortality at 30 days…
- Trial name
- NCT05105906
- Testing
- cognitive tests performed
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bipolar Disorder
Assessment of Cognitive Functions in Bipolar Patients
Assessment of cognitive function in manic bipolar patient
- Trial name
- NCT04091828
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Alzheimer Disease, Parkinson Disease
The Assessment of the Diagnosis and Prognosis of Patients With Alzheimer Disease or Parkinson Disease With Cognitive Impairment by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04434898
- Where
- Taiwan
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injuries, Neurogenic Bladder
Treatment of Spinal Cord Injury Patients for Neurogenic Bladder: Anticholinergic Agent vs. Mirabegron
We propose to test the hypothesis that cognition will improve with substitution of mirabegron for the anticholinergic agent (AC) in elderly persons with spinal cord injury (SCI) who require neurogenic bladder (NGB) treatment.
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Cognitive Change
- Trial name
- SCIMYR (NCT03612401)
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Primary Biliary Cholangitis (PBC)
A Two-part Study to Investigate the Effects in Adults of Two Doses of Golexanolone in Patients With Primary Biliary Cholangitis (PBC) With Fatigue and Cognitive Dysfunction
The present phase 1b/2 randomised, double-blind, placebo-controlled, two-part study is designed to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of two dose levels of golexanolone…
- Trial name
- NCT07304843
- Testing
- golexanolone
- Where
- 38 sites in Germany, Greece and 6 more
- Volunteers
- 207 people
- Sponsor
- Umecrine Cognition AB
Schizophrenia
Efficacy of Cognitive Remediation in Patients With Schizophrenia or Schizoaffective Disorder Stabilized on Lurasidone
The investigators hypothesize that cognitive remediation will be superior to the active control group on the change from baseline to study end point of cognitive remediation phase on both co-primary outcome measures (standardized…
- Trial name
- NCT01173874
- Testing
- Cognitive Remediation
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- New York State Psychiatric Institute
Alzheimer's Disease
A Study of LY3303560 in Healthy Participants and Participants With Alzheimer's Disease (AD)
The purpose of this study is to evaluate the safety and tolerability of the study drug, LY3303560. Side effects and laboratory results will be monitored.
- Trial name
- NCT02754830
- Testing
- LY3303560 - IV, Saline Solution - IV, LY3303560 - SC
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Multiple Sclerosis
Assessing the Effects of Ongoing Ocrelizumab (OCR) Therapy on Fatigue and Cognition in Veterans With Multiple Sclerosis
This study seeks to assess the effects of long-term ocrelizumab therapy on fatigue (extreme tiredness) as well as cognition (thinking and reasoning skills, such as memory, learning and attention), in veterans with multiple…
- Trial name
- ML45855 (NCT07181811)
- Testing
- Multiple Sclerosis patients who have been on Ocrelizumab will undergo cognitive and fatigue assessments
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anza Memon
Mild Cognitive Impairment
A Single-center, Self-controlled, Prospective Case Series Pilot Study to Assess the Effect of Lamivudine (3TC) on Neurocognitive Impairment Biomarkers and Type-I IFN (Interferon)-Stimulated Genes in the Plasma of Patients With Mild Cognitive Impairment (MCI)
To assess the ability of lamivudine to lower the levels of neurocognitive impairment biomarkers in the plasma of patients with MCI and positive AD biomarkers in a 24 weeks-treatment period.
- Trial name
- NCT06519357
- Testing
- Lamivudine 300 MG
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction in Elderly and it's Relation With Sleep Disorders and Melanin Concentrating Hormone
The aim of this study is to explore the relationship between preoperative sleep disorders, melanin-concentrating hormone (MCH), and delayed neurocognitive recovery early after surgery in older adult patients undergoing spinal…
- Trial name
- NCT07392840
- Volunteers
- 50 people
- Sponsor
- Minia University
Obsessive Compulsive Disorder
Modification of Cerebral Activity of Obsessive Compulsive Disorder (OCD) Patients During Cognitive and Behavioral Therapy
Obsessive compulsive Disorder (OCD) is a frequent psychiatric disorder. Obsessions and compulsions are the two manifestations of this disease.
- Trial name
- TOC TOC (NCT01331876)
- Testing
- Cognitive and behavioral Therapy
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
End-Stage Renal Disease
Decreasing Depression and Anxiety and Their Effect on QoL of ESRD Patients (End-Stage Renal Disease)
This study evaluates the effect of a single cognitive-behavioral intervention (CBI) in a control group against the same CBI plus the strengthening of resiliency skills in an experimental group, on ESRD patients.
- Trial name
- ESRD (NCT03330938)
- Testing
- CBI and Resilience, Cognitive-behavioral Intervention
- Where
- Mexico
- Volunteers
- 50 people
- Sponsor
- Hospital Civil de Guadalajara
Schizophrenia
Study to Evaluate the Efficacy and Safety of GSK239512 in Schizophrenia
This study aims to evaluate the cognitive enhancing effects and tolerability of GSK239512 compared to placebo in patients with schizophrenia
- Trial name
- NCT01009060
- Testing
- GSK239512
- Where
- 15 sites in United States
- Volunteers
- 50 people
- Sponsor
- GlaxoSmithKline
Parkinson Disease
Sleep Quality, Cognition, and Disease Severity in Parkinson's Disease
The goal of this observational study is to investigate the relationship between sleep quality, cognitive functions, and disease severity in individuals with Parkinson's disease.
- Trial name
- NCT07536490
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Ankara University
Stroke, Acute, Swallowing Disorder
Functionality, Cognition And Swallowing Skills In Patients With AcuteSTROKE
Aim: Studies in which the results of the screening test evaluating swallowing skills in acute stroke patients are evaluated together with other components that may affect swallowing function are limited.
- Conditions
- Stroke, Acute, Swallowing Disorder, Cognitive Impairment, Stroke
- Trial name
- NCT06288243
- Testing
- Clinician-observed assessment tests
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Medipol University
Chronic Obstructive Pulmonary Disease
Physical Activity Promotion Added to Standard Care Pulmonary Rehabilitation and Cognitive Behavioural Therapy
In patients with Chronic Obstructive Pulmonary Disease (COPD) daily physical activity is reduced compared to healthy age-matched individuals.
- Trial name
- NCT03749655
- Testing
- Physical Activity Promotion
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Northumbria University
Heart Failure With Reduced Ejection Fraction
Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients
Cognitive impairment (CI) is highly prevalent in patients with heart failure with reduced ejection fraction (HFrEF), which has significant implications for disease management, quality of life and clinical outcomes.
- Trial name
- LYRIC-HF (NCT07695090)
- Testing
- Lumacaftor 200 MG
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Qanatpharma AG
Chronic Fatigue Syndrome., Muscular Diseases.
Clinical Trial to Evaluate the Effectiveness of Acupuncture as a Treatment in Patients Diagnosed With CFS.
background: The Chronic Fatigue Syndrome (CFS) presents many disturbances multidimensional affect holistically to people who have the disease and current management of fatigue, pain, anxiety, depression and sleep disturbances…
- Conditions
- Chronic Fatigue Syndrome., Muscular Diseases., Cognitive Impairment, Sleep Disturbances
- Trial name
- AV/AS (NCT01907711)
- Testing
- Acupuncture.
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Vall d'Hebron
Eosinophilia-Myalgia Syndrome
L-5-HTP-Related EMS
In 1989 more than 1500 people who took the dietary supplement L-tryptophan for insomnia and depression developed eosinophilia myalgia syndrome (EMS)-a potentially fatal disease characterized by an excess of a type of white blood…
- Trial name
- NCT00001918
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Mental Health (NIMH)