Clinical trials: Cognitive Disorder Patients and Cognitive Assessment
Prediabetes
PREPARE: "Prediabetes Research and Education Promoting Activity & Responsible Eating"
The purpose of this study is to determine if a 6-month community-based prediabetes lifestyle and behaviour change intervention (called, PREPARE) for middle and older adults with prediabetes will result in positive lifestyle…
- Trial name
- PREPARE (NCT01396772)
- Testing
- PREPARE education program, standard of care presentation
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Brescia University College
Frail Elderly Syndrome
HOPE (Healthy Older People Everyday) To Age in Place
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented…
- Trial name
- NCT03797352
- Testing
- Multicomponent exercise
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Stroke, Cognitive Impairment
Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment
The investigators would like to conduct a double blind placebo-controlled prospective study to show the impact of a treatment combining a specific cognitive rehabilitation program and acetylcholinesterase inhibitors on executive…
- Trial name
- COGICRehab (NCT01508494)
- Testing
- Galantamine
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Brain Tumor
Assessment of Cognitive Functions and Quality of Life in Patients Undergoing Surgery for Supratentorial Brain Tumor
Primary brain tumors are highly associated with neurocognitive deficit and poor quality of life. There are number of studies indicating that brain tumors and their treatment modalities are often related to cognitive dysfunction.
- Trial name
- NCT02428972
- Testing
- Propofol, Sevoflurane
- Volunteers
- 30 people
- Sponsor
- All India Institute of Medical Sciences
Mucopolysaccharidosis Type II, Metabolic Diseases
A Multi-cohort Study of Safety, Efficacy, PK and PD of GNR-055 in Patients With Mucopolysaccharidosis Type II
This is phase 2/3 study to evaluate the safety, pharmacokinetics, pharmacodynamics, and efficacy of the investigational product GNR-055 in MPS II (Hunter syndrome) patients of different age groups.
- Trial name
- NCT05208281
- Testing
- GNR-055 1.0-2.0-3.0 mg/kg, GNR-055 2.0 mg/kg, GNR-055 3.0 mg/kg
- Where
- 5 sites in Russia
- Volunteers
- 32 people
- Sponsor
- AO GENERIUM
Dementia, Alzheimer Disease
A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment
The purpose of this study is to evaluate the efficacy and safety of galantamine treatment in patients with mild cognitive impairment.
- Trial name
- NCT00236431
- Testing
- Galantamine hydrobromide
- Volunteers
- 1,063 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cognitive Impairment, End Stage Renal Disease
A Study to Assess the Tolerability and Efficacy of AKST1210 in Patients on Hemodialysis With Cognitive Impairment
This study will evaluate the tolerability, feasibility, and efficacy of the AKST1210 column in subjects with end-stage renal disease with cognitive impairment (ESRD-CI) undergoing hemodialysis 3 times per week.
- Trial name
- NCT04527328
- Testing
- AKST1210, Hemodialysis
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Alkahest, Inc.
Type 2 Diabetes
Assessment of Cognitive Function and Functional Performance in Patients With Type 2 Diabetes
Diabetes is a chronic metabolic disease that is becoming a growing public health problem worldwide, affecting people's lives in many ways.
- Trial name
- NCT07390292
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Breast Cancer, Lymphoma
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy
Cognitive impairments in cancer patients represent an important clinical problem. Studies to date estimating prevalence of difficulties in memory, executive function, and attention deficits have been limited by small sample sizes…
- Trial name
- CANTAB (NCT01382082)
- Where
- 29 sites in United States
- Volunteers
- 1,432 people, healthy volunteers welcome
- Sponsor
- University of Rochester NCORP Research Base
Cognitive/Functional Effects, Recurrent Breast Cancer
Vascular and Cognitive Assessments in Patients With Breast Cancer Undergoing Chemotherapy After Surgery
This clinical trial studies vascular and cognitive assessments in patients with breast cancer undergoing chemotherapy after surgery.
- Conditions
- Cognitive/Functional Effects, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT01483196
- Testing
- ultrasound imaging, questionnaire administration, assessment of therapy complications
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia
Neurophysiological Evaluation of Schizophrenia Patients After Cognitive and Physical Intervention
Neurophysilogical, neuropsychological evaluation and cognitive and physical training
- Trial name
- NCT03899662
- Testing
- Cognitive Training, Physical Training
- Where
- Greece
- Volunteers
- 4 people
- Sponsor
- Aristotle University Of Thessaloniki
Multiple Sclerosis, Primary Progressive
Cognition Evolution and MRI Markers in PPMS Patients on 2 Years
Cognitive impairment is nowadays more and more recognized as an important feature of the multiple sclerosis (MS) disease. Cognitive disorders frequency in MS is estimated between 40 and 60%.
- Trial name
- PRO-COG (NCT03455582)
- Testing
- Clinical assessment, Ecological evaluation, Neuropsychological evaluation
- Where
- 3 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Breast Cancer
Neuropsychologic and Electrophysiological Features of Cancer-Related Cognitive Side Effects in Racial and Ethnic Minority Breast Cancer Patients
This study is being done to find out if it is possible to enroll minority women with breast cancer in a study of how chemotherapy may affect their ability to answer certain questions and perform certain tasks that measure brain…
- Trial name
- NCT01473680
- Testing
- EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire
- Where
- 4 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Alzheimer's Disease
Resveratrol for Alzheimer's Disease
Resveratrol is derived from plants and is found in highest levels in red wine and the skin of red grapes. A recent study reported that monthly and weekly consumption of red wine is associated with a lower risk of dementia.
- Trial name
- NCT01504854
- Testing
- Resveratrol
- Where
- 26 sites in United States
- Volunteers
- 119 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Alzheimer Disease, Mild Alzheimer Disease
Repurposing Siponimod for Alzheimer's Disease
Collaboration with multiple sclerosis (MS) specialty colleagues led us to formulate the central hypothesis that Siponimod could lower the rate of brain atrophy in Alzheimer's disease (AD) subjects.
- Conditions
- Alzheimer Disease, Mild Alzheimer Disease, MCI With Increased Risk for Alzheimer Disease, Cognitive Impairment, Mild
- Trial name
- SIPO1-AD (NCT06639282)
- Testing
- Siponimod
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Schizophrenia Disorder
Assessment of Physical Activity, Balance, Muscle Strength, and Cognitive Function in Patients Diagnosed With Schizophrenia
Schizophrenia is a serious mental health condition that affects individuals' thinking, perception, emotional responses, and behavior.
- Trial name
- NCT07141966
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Coronary Artery Disease
The Relationship Between Cognitive Status and Exercise Capacity, Fatigue Perception in Coronary Artery Patients
The study aimed to examine the relationship between cognitive status, exercise capacity, and fatigue perception in coronary artery disease patients.
- Trial name
- NCT06246201
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Dementia, Alzheimers Disease
Establishment of a Bank of Biospecimens for Future Research on Age-related Cognitive Disorders
This study is collecting tissue specimens (blood, urine and saliva) from up to 1000 patients, with and without cognitive disorders, to store in the Bio Bank for future research.
- Trial name
- NCT00911690
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Mild Cognitive Impairment, Alzheimer's Disease(AD)
Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild Cognitive Impairment and Prodromal Alzheimer's Disease
This study is a multicenter, randomized, double-blind, parallel-group, prospective confirmatory clinical trial designed to evaluate whether the Neuclare medical device can temporarily improve executive function (planning and…
- Trial name
- NCT07239310
- Testing
- Participants receive Neuclare Device while continuing their cognitive medication
- Where
- 7 sites in South Korea
- Volunteers
- 138 people
- Sponsor
- Deepsonbio
Down Syndrome
Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome
The purpose of this study is to determine whether folinic acid can improve developmental quotient of young Down syndrome patients, given that these present signs of folate deficiency which are known to cause reversible…
- Trial name
- NCT00294593
- Testing
- folinic acid
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut Jerome Lejeune