Clinical trials: Cognitive Disorders
Unrecognized Condition
The Influence of Rhythm, Cognitive Task and Physical Activity on the Cardiac ANS in Chronic Stroke Patients
Autonomic dysfunction is a common complication of stroke that may lead to poor rehabilitation outcomes and to increase in mortality.
- Trial name
- NCT03016416
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Dementia, Cognitive Decline
Choral Singing For the Prevention of Dementia
To evaluate the efficacy of choral singing in the prevention of dementia and examine the underlying mechanisms using Magnetic Resonance Imaging (MRI) technique and a panel of peripheral biomarkers in venous blood and urine.
- Trial name
- NCT02919748
- Testing
- Choral Singing, Health Education Program
- Where
- Singapore
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Major Depressive Disorder (MDD), Bipolar Disorder Depression
Cognitive Effects Associated With Hippocampal Neurogenesis Induced by ECT in the Treatment of Depression
Electroconvulsive therapy (ECT) is the treatment of choice for drug-resistant depression (30% of patients), or when there is a short-term risk to the patient's life.
- Trial name
- CONHECT (NCT06661616)
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Alzheimer Disease (AD)
Daridorexant for Alzheimer Disease Prevention
This study will evaluate whether daridorexant, a DORA sleep medication, can support brain health by promoting the clearance of proteins linked to the development and progression of Alzheimer's disease.
- Trial name
- PAD-DORA (NCT07213349)
- Testing
- Daridorexant 50 mg
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Aging Well, Aging Problems
Aquatic Exercise for Cognition and Mobility in Older Adults
The purpose of this study is to assess the effects of an aquatic exercise program on cognition and physical function of older adults.
- Conditions
- Aging Well, Aging Problems, Cognitive Change, Gait, Unsteady
- Trial name
- NCT05501249
- Testing
- Aquatic Integrated Cognitive Motor Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emily Dunlap
Dissociation, Auditory Hallucination
Psychological Therapy for Dissociation, Trauma and Voices: A Single Case Experimental Design
Connection to Environment with Cognitive Therapy (CONNECT): A Single-Case Experimental Design Exploring Dissociative Experiences and Voices Emerging empirical evidence has suggested that dissociation is a robust determinant of…
- Conditions
- Dissociation, Auditory Hallucination, Trauma, Psychological, Psychosis
- Trial name
- CONNECT (NCT04127526)
- Testing
- Connection to Environment with Cognitive Therapy (CONNECT)
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Hypoxia, Ketosis
Ketone Esters for Optimization of Cognitive Performance in Hypoxia
This study will investigate the effects of ketone ester drinks on cognitive performance in hypoxia.
- Trial name
- NCT03659825
- Testing
- Ketone Ester, Hypoxic exposure
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- HVMN Inc
Hypoglycemia
Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery
The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy individuals and how well changes in (interstitial) tissue glucose levels correlate with changes in cognitive function as compared to…
- Trial name
- NCT01283126
- Testing
- euglycemic and hypoglycemic clamp
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Cognitive Decline, Cancer
Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Cancer survival rates have increased dramatically in recent years. However, many survivors report cognitive decline following treatment, which significantly impairs their quality of life.
- Trial name
- CRCI (NCT04210778)
- Testing
- Cognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Primary Insomnia
Enhancing Sleep Onset: the Power of Tactile Breath Pacer in Cognitive Behavioral Therapy for Insomnia
The purpose of the study is to evaluate the effectiveness of technology-assisted breathing exercises combined with Cognitive Behavioral Therapy for Insomnia (CBT-I) in primary insomnia patients to investigate.
- Trial name
- MOONBIRD (NCT06475378)
- Testing
- Moonbird, Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Cognitive Dysfunction, Alzheimer Disease
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06733714
- Testing
- Transcranial Alternating Current Stimulation, Digital Cognitive Training
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Brain Concussion, Mild Cognitive Impairment
Development of a Neurocognitive Screening Test
This research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75.
- Trial name
- NCT02597504
- Testing
- Pen and paper neuropsychological test, Quick Test
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Stroke, Acute Ischemic, Cognitive Impairment
Effect of Preventive Cognitive Training on Cognitive Impairment After Stroke in Acute Stage
Post-stroke cognitive impairment(PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for 6 months.
- Trial name
- NCT05648149
- Testing
- hierarchical multi-dimensional cognitive training scheme based on computer
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy
Executive Training and Brain in Adolescent
The purpose of this study is to investigate the cognitive and brain effects of inhibitory control (IC) training at adolescence.
- Trial name
- APEX-ADO (NCT03084848)
- Testing
- Training
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Stress, Acute Stress Reaction
The Effect of Breathing on Cognitive Performance and Stress
The purpose of this study is to determine the effectiveness of different breathing techniques on biomarkers of stress and cognitive performance following the Trier Social Stress Test.
- Conditions
- Stress, Acute Stress Reaction, Breathing Techniques, Cognitive Performance
- Trial name
- NCT06986135
- Testing
- Box Breathing, Prolonged Exhalation, Normal Breathing
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Texas State University
Alzheimer's Disease, Aging
aeRobic Exercise and Cognitive Health
The purpose of the aeRobic Exercise and Cognitive Health (REACH) study is to understand how an aerobic exercise intervention might help promote brain health and cognition, thereby delaying the onset of clinical symptoms of…
- Trial name
- REACH (NCT02384993)
- Testing
- Enhanced Physical Activity
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Depression
Effectiveness of Telephone Versus Face-to-Face CBT in Treating People With Depression
This study will compare the effectiveness of telephone versus face-to-face administration of cognitive behavioral therapy in treating people with depression.
- Trial name
- NCT00498706
- Testing
- Telephone-administered cognitive behavioral therapy (T-CBT), Face-to-face administered CBT (FtF-CBT)
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Postoperative Complications, Delirium
Donepezil in Preventing Delirium in Hospitalized Elderly
The purpose of this study is to explore the efficacy of a perioperative daily dose of Donepezil (a cholinergic enhancer) in reducing the incidence and severity of delirium.
- Trial name
- NCT00182884
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University Health
Ischemic Stroke
Neuroactive Steroids in Acute Ischemic Stroke
Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS).
- Trial name
- NCT02914106
- Testing
- Observational Study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Militar Central, Argentina
Mild Cognitive Impairment
Investigating the Efficacy of Ergothioneine to Delay Cognitive Decline (Pilot)
With the growing burden of dementia (including Alzheimer's disease), and the lack of efficacious therapies, there is an urgent need to identify new therapeutics.
- Trial name
- NCT03641404
- Testing
- L-ergothioneine
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
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