Clinical trials: Cognitive Disorders
Mild Cognitive Impairment
Digital Tools to Support Healthcare Decision Making
The goal for this project is to support the cognitive components of older adults' health-management activities through development of digital assistant technology tools tailored to three exemplar healthcare management task…
- Trial name
- CREATE P3 (NCT07485725)
- Testing
- Project 3, Phase 2: Clinical Trial
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer Disease, Frontotemporal Degeneration
In Vivo PET of Synaptic Density in Cognitive Disorders
This study will compare the discriminative power of [18F]-SynVesT-1 PET and the standard-of-care [18F]-FDG PET in different cognitive disorders (Alzheimer's disease, Frontotemporal degeneration, dementia with Lewy bodies and…
- Conditions
- Alzheimer Disease, Frontotemporal Degeneration, Dementia With Lewy Bodies, Psychiatric Disorder
- Trial name
- NCT05384353
- Testing
- [18F]-SynVesT-1
- Where
- Belgium
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spinal Cord Injuries (SCI), Depression
Evaluation of a Home-based AOMI Intervention on Cognitive Function and Depression Among Adults With SCI
The investigators propose a pilot randomized clinical trial to determine if adults with spinal cord injury (SCI) show improved cognitive function and depression following home-based Action Observation and Motor Imagery (AOMI)…
- Conditions
- Spinal Cord Injuries (SCI), Depression, Motor Imagery, Cognitive Functions
- Trial name
- NCT06708026
- Testing
- Action Observation and Motor Imagery (AOMI) training, Basic wheelchair exercises, Watch landscape videos
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment
Multidisciplinary Intervention for Mild Cognitive Impairment
The purpose of this investigation is to conduct a series of case studies on the impact of a novel functional medicine approach to improving cognitive skills, brain structure, and daily functioning for participants with Mild…
- Trial name
- (MCI) (NCT02943187)
- Testing
- Cognitive training, Nutrition
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Gibson Institute of Cognitive Research
ADHD, Attention Deficit Hyperactivity Disorder
Adolescent Changes in Brain and Behavior in Boys and Girls With ADHD
The purpose of the study is to examine the developmental trajectory of response control in boys and girls with ADHD entering adolescence.
- Trial name
- NCT05927506
- Testing
- Other
- Where
- United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Schizophrenia
The Effects of Nicotine on Cognition in Schizophrenia
Patients with schizophrenia have a variety cognitive deficits and nicotine has been shown to normalize some of these deficits. The purpose of this study is to investigate the effects of nicotine on cognition in schizophrenia.We…
- Trial name
- NCT00383747
- Testing
- transdermal nicotine patch
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder
A Comparison of CPT Versus ART Versus WL
The purpose of this research study is to compare the effectiveness of two treatments for the symptoms of Posttraumatic Stress Disorder (PTSD) with a no therapy, wait-list control condition.
- Trial name
- NCT03384706
- Testing
- Cognitive Processing Therapy (CPT), Accelerated Resolution Therapy (ART)
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Relapsing Remitting Multiple Sclerosis
Comparison of Campath and Rebif Treatment on Cognition in Multiple Sclerosis (MS)
People with multiple sclerosis (MS) often experience problems with cognitive functioning, which can be debilitating and interfere with their daily functioning.
- Trial name
- NCT00914758
- Where
- 7 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Washington Neuropsychology Research Group
Stroke, Brain Diseases
VIrtual Reality Glasses Use to Improve Lateropulsion and the Post-stroke Postural Vertical
VIRGIL is a monocentric interventional study aiming to investigate the effect of immersion in a virtual tilted room on modulation of the verticality representation (postural vertical [PV] and visual vertical [VV]), which in turn…
- Conditions
- Stroke, Brain Diseases, Cerebrovascular Disorders, Postural; Defect
- Trial name
- VIRGIL (NCT04911738)
- Testing
- Virtual Reality , immersion in a virtual titlted room
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Alzheimer Disease, Mild Cognitive Impairment
LEADing Dementia End-of-Life Planning Conversations
Advance care planning is important for all adults, but perhaps even more so for the 5.7 million persons with Alzheimer's disease or related dementia (ADRD), due to the progressive and protracted cognitive deterioration associated…
- Trial name
- LEAD (NCT05909189)
- Testing
- LEADing Dementia End-of-Life Planning Conversations
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Anemia, Sickle Cell
Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study
Sickle cell disease (SCD), also known as sickle cell anemia, is an inherited blood disease that can cause intense pain episodes and may lead to organ failure.
- Trial name
- NCT00850018
- Testing
- Monthly blood transfusion regimen, Usual care
- Where
- 14 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Apathy, Mild Cognitive Impairment
Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment
Apathy, a profound loss of initiative and motivation, is often seen in older Veterans with memory problems. Apathy leads to serious health problems, increases dependency, and caregiver burden.
- Conditions
- Apathy, Mild Cognitive Impairment, Transcranial Magnetic Stimulation, Loneliness
- Trial name
- TAMCI (NCT03590327)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Hand Weakness
Cognitive-based Prosthetics to Improve Grasp and Reaching After SCI
Rehabilitation of functional movements after spinal cord injury (SCI) requires commitment and engagement to the processes of physical therapy.
- Trial name
- NCT04577573
- Testing
- Cognition glove, Sensory brace
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Vitamin D Deficiency, Metabolic Syndrome
Vitamin D Supplementation and Metabolism in Vitamin D Deficient Elderly
The purpose of this study is to examine the effects of Vitamin D supplementation on the reasons (mechanisms) underlying the development of type 2 diabetes, metabolic syndrome (high blood pressure, cholesterol, diabetes, body…
- Trial name
- VitD (NCT01145703)
- Testing
- RDA Vitamin D3 only, Vitamin D2/3 Repletion only, Vitamin D2/3 Repletion + AEX
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Anxiety Symptoms
Effect of IATP on Cognitive Functioning in Anxious Older Adults.
Older adults with anxiety symptoms was found to be associated with greater risk of dementia. Interventions targeting signs as early as in the pre-symptomatic phase could be most effective in early prevention of dementia.
- Trial name
- NCT04413513
- Testing
- Integrated Attention Training Program (IATP), Health Education
- Where
- Hong Kong
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment, Randomized Controlled Trial
Cognitive Stimulation in Older With Mild Cognitive Impairment
The participants who carry out our program of cognitive stimulation, deteriorate at a cognitive level more slowly and can improve their score of the Spanish version of 35 points of Mini-mental State of Folstein; Mini-exam…
- Trial name
- Cognitive (NCT03831061)
- Testing
- Cognitive stimulation
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Lactose Intolerance
Effects Comparison of A1 and A2 Milk on Gastrointestinal Physiology, Symptoms and Cognitive Behavior
This is a single-site, double-blinded, randomized, controlled, 2X2 cross-over study aiming to compare effects of milk containing only A2 type beta casein versus milk containing both A1 and A2 beta casein proteins on the…
- Trial name
- NCT02406469
- Testing
- Oral consumption milk Tetra Pak
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Attention Deficit Disorder With Hyperactivity
Extra Time on Brazilian College Level Exam for Students With and Without ADHD
Standardized tests such as the Scholastic Aptitude Test (SAT) and the brazilian National High School Exam (ENEM) give more time for students with Attention Deficit and Hyperactivity Disorders (ADHD) to complete the exam.
- Trial name
- NCT06063382
- Testing
- Extended time 25%, Extended time 50%
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
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