Clinical trials: Cognitive Disorders
Dementia Disorders, Mild Cognitive Impairment (MCI)
Multimodal Biomarkers in Individual With Cognitive Impairment and Dementia
Memory problems can range from normal aging to mild cognitive impairment (MCI) to dementia. This study looks at three ways of measuring what is happening in the brain at each of these stages: a blood test (GFAP), a brain MRI…
- Trial name
- NCT07812480
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Occupational Stress
The Effect of Mindfulness-based Cognitive Behavior Therapy on Occupational Stress Management
Occupational stress is one of the leading work-related factors that influence the health of employees and their ability to work. Stress at work is unavoidable due to changing and increasing demands and types of work.
- Trial name
- NCT05626543
- Testing
- Cognitive behavior therapy (CBT) and Mindfulness-based stress reduction (MBSR) programs
- Where
- Finland
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Tampere University
Mild Cognitive Impairment
Early Intervention in Mild Cognitive Impairment (MCI) With Curcumin + Bioperine
This is an additional study to the primary Mild Cognitive Impairment (MCI) study (LSU#H04-049; NCT00243451)that is underway of PET detection of Mild Cognitive Impairment.
- Trial name
- NCT00595582
- Testing
- curcumin + bioperine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Diabetes Type 2, Metabolic Syndrome
Regulating Efficacy and Wellness in Diabetes
The propose of the study is to test the hypothesis that an eight week program consisting of walking exercise and social cognitive theory based group workshops will increase physical activity adherence six months later in older…
- Trial name
- REWinD (NCT01790724)
- Testing
- Walking exercise
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Multiple Sclerosis
GTA-MEG as a Biomarker for Cognition in MS
In this study, 100 persons with Multiple Sclerosis and 50 matched controls will be examined with magnetoencephalography (MEG), magnetic resonance imaging (MRI) and cognitive tests.
- Trial name
- NCT02851342
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cognitive Decline, Cognitive Dysfunction
Open-label, Post-marketing, Prospective Study to Assess Impact of COVID-19 on Cognitive Function in Patients
The objective of this study is to compare the impact of the coronavirus disease (SARS-CoV-2, or COVID-19) on cognitive function in the population of patients who have been diagnosed, treated and recovered from the COVID-19…
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Brain Health, Post CoV-2 Syndrome
- Trial name
- COVID19 (NCT04950673)
- Testing
- Cognivue
- Where
- 4 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cognivue, Inc.
Cognitive Change, Cognitive Impairment
The Everyday Function Intervention Trial
Loss of independence, cognitive decline, and difficulties in everyday function are areas of great concern for older adults and their families.
- Conditions
- Cognitive Change, Cognitive Impairment, Healthy Aging, Dementia
- Trial name
- EFIT (NCT04651582)
- Testing
- Cognitive Training, Cognitive Stimulating Activities
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Clemson University
Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents
Comorbid anxiety disorders affect as many as 80% of youth with autism spectrum disorders, causing substantial distress and impairment over and above the autism spectrum diagnosis alone.
- Trial name
- NCT01177969
- Testing
- Cognitive-Behavioral Therapy, Wait-list
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Obesity
Brain Electrophysiological Patterns in Obesity
There is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP) elicited by an oddball paradigm, is an…
- Trial name
- NCT00842569
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Healthy Individuals (Controls), Parkinson Disease
Motor Learning in Health and Movement Disorders: Role of Physical Activity and Advanced Devices
The goal of this clinical trial is to investigate motor responses in healthy subjects and patients with movement disorders, brain and spinal cord injury, neuromuscular diseases, or cardiovascular diseases.
- Conditions
- Healthy Individuals (Controls), Parkinson Disease, Multiple Sclerosis, Alzheimer Disease
- Trial name
- Allena-mente (NCT07066137)
- Testing
- CAREN, Control group
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Delirium, Cognitive Dysfunction
Can a New EEG Based Tool Predict Post-operative Delirium and Cognitive Dysfunction?
As the population ages and medical progress is made, many elderly patients that previously would not have been candidates for surgery are now undergoing operations.
- Trial name
- NCT03293550
- Where
- Israel
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Mild Cognitive Impairment, NAD
The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition
The purpose of this study is to determine the effects of Niagen (nicotinamide riboside, vitamin B3), on NAD levels, brain function including cognition and blood flow in people diagnosed with mild cognitive impairment (MCI).
- Trial name
- NAD (NCT02942888)
- Testing
- Nicotinamide riboside, Sugar Pill
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Mild Cognitive Impairment Due to Alzheimer's Disease, Dementia Due to Alzheimer's Disease (Disorder)
Biomarkers of Cognitive Impairment in Blood Cells
The aim of this study is to identify transcriptomic biomarkers in blood cells to diagnose early cognitive impairment. This would allow preventing the development of severe pathologies, such as Alzheimer Disease.
- Trial name
- COGNIMARK (NCT05582941)
- Testing
- No intervention will be performed.
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Depression
Cognitive Control Training for Depression
Depression is frequently characterized by patterns of inflexible, maladaptive, and ruminative thinking styles; these patterns themselves are thought to result from a combination of decreased attentional control, decreased…
- Trial name
- NCT01454141
- Testing
- Cognitive Control Training, Peripheral Vision Task
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Major Depression, Bipolar Disorder
Longitudinal Study of People Presenting for First Treatment of a Mood Disorder
The goal of this project is to study the course and outcome of illness in individuals who present with a first episode of depression or mania, or who have a recurrent disorder but have never received treatment.
- Trial name
- NCT01529905
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dementia, Telemedicine
EpxCogScreen -- A Phone-based Rapid Cognitive Screen (RCS)
EpxCogScreen is a phone-based intervention to administer the Rapid Cognitive Screen, a validated screening tool for dementia, over SMS text messaging.
- Conditions
- Dementia, Telemedicine, Cognitive Dysfunction
- Trial name
- NCT03569722
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Theodore Malmstrom, PhD
Hearing Impairment
Determine the Effect on Cognitive Impairment Measures by Providing Hearing-Assistance to Skilled Nursing Facility Residents
The purpose of the study is to see if a commercially available hearing assistance device called the PockeTalker has an effect on performance on cognitive (memory and thinking) tests among skilled nursing facility residents.
- Trial name
- DECIPHER (NCT03338751)
- Testing
- cognitive testing with HAD (PockeTalker) First, Cognitive testing without HAD First
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Cognitive Function, Cognitive Decline
Phospholipid-rich Dairy Extract for Cognitive Function
This clinical trial aims to determine whether dietary phospholipid-rich dairy milk extract improves cognitive function in adults with mild cognitive impairment and to assess its safety.
- Trial name
- NCT07011680
- Testing
- Phospholipid-rich dairy milk extract
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Cognitive Impairment, Cognitive Change
Validation of a Digital Self-Administered Cognitive Screening Tool: MoCA-XpressO
The investigators conducted a validation study for the Montreal Cognitive Assessment (MoCA)-XpressO compared to the digital-MoCA test (version 8.1) as the gold standard.
- Conditions
- Cognitive Impairment, Cognitive Change, Cognitive Deficit, Assessment, Self
- Trial name
- MoCA (NCT05879562)
- Testing
- MoCA-Xpresso
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- MoCA Clinic and Institute
Cognitive Decline, Healthy Aging
Cognitive Training for Digital Biomarkers
This study aims to conduct cognitive training for digital biomarkers among older adults.
- Trial name
- NCT06090942
- Testing
- Smartphone-based cognitive training
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University