Clinical trials: Cognitive Disorders
Alzheimer's Disease
Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects
A Phase 2/3 cross-sectional and longitudinal observational study evaluating imaging characteristics of flortaucipir in control subjects and patients with clinically defined MCI and AD dementia (AD).
- Trial name
- MCI (NCT02016560)
- Testing
- florbetapir F 18, Flortaucipir F18, Brain PET Scan
- Where
- 27 sites in United States
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Schizophrenia
Effects of Brain Stimulation on Cognition, Oscillations and GABA Levels in Schizophrenia
People with schizophrenia often have problems with attention, learning and memory and other cognitive abilities that interfere with their work and school performance.
- Trial name
- NCT04267003
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pain, Opioids
Oxidative Balance in Opioid Therapy
The oxidative - antioxidative balance is the crucial mechanism of opioid-induced immunomodulation. Additionally, impairement of cognitive function during opioid therapy is another important side- effect.
- Trial name
- NCT04227223
- Testing
- biochemical measurements
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Stroke, Internet-Delivered Cognitive Behavioural Therapy
ICBT for Persons With Stroke
Despite evidence for ICBT among those with other chronic conditions, its efficacy has yet to be evaluated among those with neurological conditions, including stroke.
- Conditions
- Stroke, Internet-Delivered Cognitive Behavioural Therapy, Depression, Anxiety
- Trial name
- NCT04667754
- Testing
- Internet-delivered Cognitive Behavioural Therapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Smoking
The Effect of Emotional Freedom Techniques (EFT) in Smokers Failing a Smoking Cessation Program
The National Health Service (NHS) stop smoking service at the Central Lancashire NHS Trust serves a diverse population of smokers, with a very good quit rate and high standards.
- Trial name
- NCT00981396
- Testing
- EFT (Emotional Freedom Techniques), CBT (Cognitive Behavioral Therapy)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Attention Deficit Hyperactivity Disorder
Study of Aripiprazole (Abilify) in Children With ADHD (Attention Deficit Hyperactivity Disorder)
To look at the cognitive effects of abilify in children with a primary diagnosis of Attention Deficit Hyperactivity Disorder. To examine the safety, effectiveness and tolerability of abilify in children with a primary diagnosis…
- Trial name
- NCT00221962
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Friedreich Ataxia
Characterisation of the Cognitive Profile of Patients Suffering From Friedreich's Ataxia
Friedreich's Ataxia (FA) Friedreich's Ataxia is a neurodegenerative disease caused by a homozygous expansion of the GAA triplet repeats of the frataxin gene (FXN). FA usually begins in childhood or adolescence.
- Trial name
- CPCAF (NCT05874388)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mental Health Issue, Anxiety Disorders
Delivering ICBT to Address Mental Health Challenges in Correctional Officers and Other Public Safety Personnel
Public safety personnel (PSP) have regular and often intense exposure to potentially traumatic events at work and are at higher risk for developing mental health problems such as posttraumatic stress disorder (PTSD).
- Conditions
- Mental Health Issue, Anxiety Disorders, Depressive Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT04666974
- Testing
- iCBT, In-Person CBT
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Dr. Nazanin Alavi
Parkinson Disease
Comparison of Different Rehabilitation Protocols in Parkinson's Disease With Postural Instability and Gait Disorders
The aim of the study is to compare the effects of 2 different dosages and modalities of motor-cognitive rehabilitation in Parkinson's disease with postural instability and gait disorders (PD-PIGD) on clinical features…
- Trial name
- NCT05799690
- Testing
- Gait and balance training with dual-task + action observation and motor imagery (six weeks), Gait and balance training with dual-task (six weeks), Gait and balance training with dual-task + action observation and motor imagery (twelve weeks: 6 + 6)
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Prof. Massimo Filippi
Breast Cancer, Chemotherapeutic Agent Toxicity
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
RATIONALE: Gathering information over time from laboratory tests, imaging scans, and assessment tests may help doctors learn more about the side effects of chemotherapy and plan the best treatment.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Fatigue
- Trial name
- NCT00755313
- Testing
- trastuzumab, aromatase inhibition therapy, carboplatin
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mild Cognitive Impairment, Dementia
Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)
The purpose of this research is to investigate the long-term effectiveness and safety of new Alzheimer's disease treatments, particularly monoclonal antibody therapies like lecanemab and donanemab, as well as to enhance…
- Conditions
- Mild Cognitive Impairment, Dementia, Subjective Cognitive Decline (SCD), Alzheimer Disease
- Trial name
- JOY-ALZ (NCT06889818)
- Where
- 3 sites in South Korea
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Mild Cognitive Impairment
Effects of Alpha-lactalbumin Intake on Metabolic and Cognitive Functions in Elderly
Aging modifies the metabolic pathway of the neurotransmitter serotonin by reducing the synthesis rate and increasing the breakdown rate of serotonin, possibly related to the observed enhanced sensitivity of the serotonergic…
- Trial name
- NCT02082418
- Testing
- Alpha-lactalbumin, Whey, Casein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Chronic Heart Failure (CHF)
Effect of a Structured Nursing Intervention Incorporating Sleep Hygiene and Cognitive-Behavioral Strategies on Sleep Quality Among Patients With Chronic Heart Failure
This study aims to evaluate the effectiveness of a structured nursing intervention incorporating sleep hygiene education and cognitive-behavioral strategies on improving sleep quality among patients with chronic heart failure.
- Trial name
- Heart failure (NCT07747597)
- Testing
- Structured Nursing Intervention Incorporating Sleep Hygiene and Cognitive-Behavioral Strategies
- Where
- Jordan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Al-Zaytoonah University of Jordan
Subjective Cognitive Decline, Preclinical Alzheimer's Disease
Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD
This study is affiliated to Sino Longitudinal Study on Cognitive Decline, SILCODE. To establish models of normal and pathological cognitive aging.To collect the longitudinal data of SCD population, to study the dynamic changes of…
- Trial name
- NCT03370744
- Testing
- Neuropsychological scale
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- XuanwuH 2
Postoperative Cognitive Dysfunction
Risk Factors for Early POCD in the Patients With PSM Undergoing CRS-HIPEC
Objectives to investigate the incidence and associated factors for early postoperative cognitive dysfunction in the patients with peritoneal surface malignancies undergoing cytoreductive surgery and hyperthermic intraperitoneal…
- Trial name
- NCT02462564
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wuhan University
Depression
Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study
To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.
- Trial name
- NCT02888509
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Cognitive Impairment, Cognitive Decline
Cognitive Screening Made Easy for PCPs - Administrative Supplement
This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care.
- Conditions
- Cognitive Impairment, Cognitive Decline, Dementia, Mild
- Trial name
- NCT06928298
- Testing
- RACS app
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Anorexia Nervosa
Auditory Sensory Attenuation in Anorexia Nervosa
The goal of this observational cross-sectional study is to test the sensory attenuation effect with auditory stimuli comparing women affected by anorexia nervosa and healthy-weight women.
- Trial name
- UdSA_AN (NCT06298526)
- Where
- Italy
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obsessive-Compulsive Disorder and Symptoms
Brief Anxiety Sensitivity Treatment for Obsessive Compulsive Symptoms
Obsessive-compulsive disorder (OCD), characterized by recurrent obsessions and/or compulsions, is a disabling psychiatric condition affecting approximately 2-3% of the population.
- Trial name
- COAST (NCT02635178)
- Testing
- Cognitive Anxiety Sensitivity Treatment, Physical Health Education Training
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Florida State University
Mild Cognitive Impairment, Cognitive Impairment
Study of Nasal Insulin to Fight Forgetfulness - Device Study
The SNIFF Device study will involve using a device to administer insulin through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body.
- Trial name
- NCT03857321
- Testing
- Insulin, intranasal nebulizer-like device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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