Clinical trials: Cognitive Disorders
Subjective Cognitive Impairment, Mild Cognitive Impairment
Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active…
- Conditions
- Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03330470
- Testing
- exercise, carnosine supplementation, stretching
- Where
- 3 sites in Slovakia, Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Smoking
The Effect of Emotional Freedom Techniques (EFT) in Smokers Failing a Smoking Cessation Program
The National Health Service (NHS) stop smoking service at the Central Lancashire NHS Trust serves a diverse population of smokers, with a very good quit rate and high standards.
- Trial name
- NCT00981396
- Testing
- EFT (Emotional Freedom Techniques), CBT (Cognitive Behavioral Therapy)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Metabolic Syndrome, Protection Against, Diet, Healthy
Strong Families Start at Home/Familias Fuertes Comienzan en Casa
The goal of this clinical trial is to test the ability of a home-based parental nutrition intervention to improve diet quality in preschool aged children within low-income, Latinx/Hispanic families.
- Trial name
- NCT06099288
- Testing
- Home-Based Video and Motivational Interviewing Intervention, Read Educate and Develop Youth (READY) Comparison
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Brown University
Dementia, Cognitive Impairment
Functionally-tailored Oral Care Intervention for Community-dwelling Older Adults With Dementia and Their Caregivers
The specific aims of this study are: Aim 1. Develop a staged and modifiable dyadic oral care intervention to provide functionally-tailored oral care rehabilitation for community-dwelling persons with dementia (PWD) and need-based…
- Trial name
- NCT04238520
- Testing
- Functionally Tailored Oral Care Intervention, Control Intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Xi Chen
Subjective Cognitive Complaint, Activities Daily Living
Community-based Cohort of Functional Decline in Subjective Cognitive Complaint Elderly
Background With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system.
- Conditions
- Subjective Cognitive Complaint, Activities Daily Living, Dementia, Alzheimer Disease
- Trial name
- NCT04265482
- Where
- Chile
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Geroscience Center for Brain Health and Metabolism (Gero)
Huntington Disease
Comparison Between [11C]UCB-J and [18F]SynVest-1 PET in HD.
Positron Emission Tomography (PET) is a functional imaging technique, which enables in vivo visualization of biological molecules expressed in human tissues.
- Trial name
- NCT05360082
- Testing
- [11C]UCB-J PET, [18F]SynVest-1 PET
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Williams Syndrome, Autism Disorder
Research on the Molecular Mechanism of Cognitive Differences Between Williams Syndrome and Autism Spectrum Disorder
Williams Syndrome (WS) is a rare neurodevelopmental disorder, usually caused by microdeletions of approximately 26 genes in the long arm (7q11.23) region of chromosome 7.
- Trial name
- WS and ASD (NCT07509879)
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Neoplasms
Assessment and Rehabilitation of Cognitive Impairments in Pediatric Survivors of Cancer
This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.
- Trial name
- NCT00490334
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Stanford University
Alzheimer Disease, Huntington Disease
Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects
This study has been designed to confirm, in healthy subjects, the lack of a clinically important pharmacokinetic interaction between Dimebon, at the proposed maximum commercial dose of 20 mg TID (administered every 8 hours), and…
- Trial name
- NCT00831506
- Testing
- digoxin, dimebon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Congenital Heart Disease
The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
The main purpose of this proposal is to perform novel MRI analyses to determine the brain organizational changes associated with altered executive function and the modulating role of variants in neuroresilience and hypoxia…
- Trial name
- NCT05258981
- Testing
- MRI
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Mild Cognitive Impairment
PET Measures of CSF Clearance in Preclinical Alzheimer's Disease
The purpose of this study is to measure cerebrospinal fluid (CSF) clearance. CSF cushions the brain from impact and carries waste products from the brain to the bloodstream. This process is known as clearance.
- Trial name
- NCT03663387
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Dementia, Cognitive Decline
Preventing Cognitive Decline: The CITA GO-ON Multi-domain Intervention Study
The GOIZ ZAINDU Gipuzkoa - GO - ON Study is an intervention trial to evaluate the efficacy of dementia prevention strategies in cognitively frail people.
- Conditions
- Dementia, Cognitive Decline, Prevention, Life Style
- Trial name
- CITA GO-ON (NCT04840030)
- Testing
- Multimodal intervention (MM-int)
- Where
- Spain
- Volunteers
- 1,094 people, healthy volunteers welcome
- Sponsor
- Fundacion CITA-alzheimer
Parkinson Disease
The Dutch Parkinson and Cognition Study
Parkinson Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms.
- Trial name
- DUPARC (NCT04180865)
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Dementia, DM
Early Detection of Cognitive Dysfunction in Diabetes
The rate of cognitive decline due to ageing is increased 1.5-fold to 2.0-fold in individuals with type 2 diabetes.There are no established specific treatment measures to prevent or ameliorate cognitive impairments in patients…
- Conditions
- Dementia, DM, MCI
- Trial name
- NCT01830998
- Where
- 3 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Emotions, Memory Deficits
Brain Response to Treatment for Pediatric PTSD
This study will examine how brain activation changes as a result of behavioral treatment for posttraumatic stress disorder (PTSD) in adolescents.
- Conditions
- Emotions, Memory Deficits, Post-traumatic Syndrome
- Trial name
- NCT01806701
- Testing
- Trauma-focused cognitive behavioral therapy
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Stanford University
Post Acute Sequelae of SARS CoV 2 Infection, Obstructive Sleep Apnea
Predictors of Post-COVID-19 Clinical and Cognitive Consequences
The CDC describes Post-acute sequelae of SARS-COV-2 infection (PASC) for the wide range of physical and mental health consequences experienced by some patients.
- Trial name
- SCLC (NCT06291870)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Sexual Abuse of Child (If Focus of Attention is on Victim)
A 1-year Program to Treat Children Who Have Been Victims of Child Sexual Abuse
Our goal in this study is examine if a program designed to decrease the severity of Post-Traumatic Stress Disorder symptoms in sexually abused children between the ages of 8-12 was effective.
- Trial name
- NCT02181751
- Testing
- Trauma Focused Cognitive Behavioural Therapy Group
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Little Warriors
Anxiety, Coping Skills
Building Cognitive Behavioural Skills With StoryBooks to Reduce Emotional Difficulties in Kindergarten Years
This research aims to ask (1) Are child and parent measures of coping skills, anxiety and other outcomes reliable (2) How feasible and acceptable is the proposed CB preventative program and protocol (3) Can a preliminary…
- Conditions
- Anxiety, Coping Skills, Socio-emotional Well-being
- Trial name
- B-READY (NCT07425951)
- Testing
- Cognitive Behavioural, Language
- Where
- Singapore
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Substance Abuse
Computer-assisted Delivery of Cognitive Behavioral Therapy for Mental Health and Addictions in Canada
Computer-based Training for Cognitive Behavioural Therapy (CBT4CBT) is a new on-line addiction treatment developed by Dr Kathleen Carroll at the Yale School of Medicine in New Haven, Connecticut.
- Trial name
- NCT03230669
- Testing
- cbt4cbt
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Obesity, Cognitive Ability, General
Physical Activity and Intermittent Exercise Training for Cardiovascular and Cognitive Gain in Obese Women
One hundred participants from a combination of (a) local advertisements and/or (b) those whose details are held on a research database (of previous volunteers indicating willingness to be contacted about future studies) will be…
- Conditions
- Obesity, Cognitive Ability, General, Cardiovascular Disease
- Trial name
- NCT02853279
- Testing
- Interval exercise training, Continuous exercise training (CON)
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Leeds
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