Clinical trials: Cognitive Dysfunction, Postoperative, open to volunteers
Postoperative Cognitive Dysfunction
Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin
Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary…
- Trial name
- NCT02832193
- Where
- 2 sites in Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Meningioma, Skull Base Meningioma
Cognitive Status After Removal of Skull Base Meningioma
The purpose of this prospectively enrolling trial is to assess long-term cognitive outcomes of patients undergoing surgery for resection of a meningioma associated with the frontal and temporal lobes.
- Conditions
- Meningioma, Skull Base Meningioma, Frontal Meningioma, Temporal Meningioma
- Trial name
- NCT04635657
- Testing
- Long-term Cognitive testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Postoperative Cognitive Dysfunction, Alzheimer Disease
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation
- Trial name
- TAU-PET (NCT07871487)
- Testing
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Delirium (POD)
Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery
Postoperative delirium (POD) is a common and serious neurocognitive complication after surgery, particularly in elderly patients undergoing major cancer surgeries.
- Trial name
- NCT07627906
- Testing
- Group ketofol, Group ketodex, Group Control
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Cairo University
Postoperative Cognitive Dysfunction, Postoperative Delirium
Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery
To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in…
- Trial name
- NCT07192549
- Testing
- Sevoflurane group, Propofol group
- Volunteers
- 200 people
- Sponsor
- General Hospital of Ningxia Medical University
Gastroesophageal Cancer (GC), Postoperative Delirium (POD)
Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer
The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery.
- Conditions
- Gastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty
- Trial name
- CASE (NCT06687291)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Karolinska Institutet
Postoperative Cognitive Dysfunction
Use of Transcranial Magnetic Stimulation in the Post-Operative Cognitive Dysfunction in Elderly
Postoperative Cognitive Dysfunction (POCD) is a prevalent condition with significant clinical, social, and financial impacts on patients and healthcare services.
- Trial name
- NCT06658769
- Testing
- Theta Burst Stimulation
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- University of Sao Paulo General Hospital
Ischemia, Cerebrovascular Ischemia
LA Improves the Prognosis of Patients With ICVD
Ischemic cerebrovascular disease will cause serious harm to the life and safety of patients, and the treatment prognosis is poor.
- Conditions
- Ischemia, Cerebrovascular Ischemia, Cognitive Impairment
- Trial name
- NCT05845983
- Testing
- Lactobacillus acidophilus, Maltodextrin
- Volunteers
- 236 people
- Sponsor
- Huaqiu Zhang
Postoperative Cognitive Dysfunction (POCD)
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery.
- Trial name
- OPCAB-POCD (NCT07643194)
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
Neurocognitive Disorder, Cardiac Surgery
Impact of Preoperative Mild Cognitive Impairment on Postoperative Delirium in Patients Undergoing Cardiac Surgery
This study is intended to explore the impact of mild cognitive impairment on the incidence of delirium after cardiac surgery in older patients.
- Trial name
- NCT07878676
- Where
- China
- Volunteers
- 261 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Postoperative Delirium, Postoperative Cognitive Dysfunction
Ketamine and Dexmedetomidine for Delirium in Joint Arthroplasty
This prospective, randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of intraoperative ketamine and dexmedetomidine on the incidence of postoperative delirium (POD) and postoperative…
- Trial name
- NCT06963294
- Testing
- Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Frailty, Cognitive Impairment
Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total…
- Conditions
- Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty
- Trial name
- ORTOPODCZ (NCT07432009)
- Where
- 7 sites in Czechia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Older Patients, Cognitive Impairment
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD).
- Conditions
- Older Patients, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation, Delayed Neurocognitive Recovery
- Trial name
- NCT06482749
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 3 sites in China
- Volunteers
- 568 people
- Sponsor
- Peking University First Hospital