Clinical trials: Cognitive Dysfunction, open to volunteers
Long COVID, Post-COVID Conditions
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue
Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life.
- Conditions
- Long COVID, Post-COVID Conditions, Fatigue, Cognitive Dysfunction
- Trial name
- NEUROSTIM-LC (NCT07709234)
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 20 people
- Sponsor
- University of Las Palmas de Gran Canaria
Cognitive Impairment, High Fall Risk
Fall Prevention in Mild Cognitive Impairment
Falls represent the leading cause of hospitalization, nursing home admissions, disability and mortality for older adults with annual healthcare costs over $50 billion.
- Trial name
- NEUROFALL (NCT07507812)
- Testing
- Virtual Neurophysiological Rehabilitation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Cancer
Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment
This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome.
- Trial name
- SPARC (NCT06800092)
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabete Mellitus, Cognitive Impairment
Predicting the Risk of Diabetic Neurodegenerative Disorders by Artificial Intelligence Tools Based on Retinal Imaging
Diabetic Retinopathy (DR) is the most frequent complication of diabetes, and its presence and severity are related to the appearance of both micro and macrovascular events.
- Trial name
- NCT06541834
- Testing
- Retinal imaging
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Ospedale San Raffaele
Dementia, Cognitive Dysfunction
Preventing Loss of Independence Through Exercise in Community Living Centers
Approximately 40,000 older Veterans with complex care needs receive long-term care in VA Community Living Centers (CLCs). Many CLC staff have limited specialized training to engage Veterans with dementia.
- Trial name
- PLIE-CLC (NCT06972004)
- Testing
- Preventing Loss of Independence through Exercise (PLIE)
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PARKINSON DISEASE (Disorder), Parkinson
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Gut problems, such as constipation, can have an important impact on quality of life of people who have them, and have been associated with higher risk of developing neurological diseases such as Parkinson's or Alzheimer's…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson, Parkinson Disease, Parkinson s Disease
- Trial name
- Met-Pro (NCT07786116)
- Testing
- Probiotic Supplementation with L. reuteri
- Where
- United Kingdom
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Cognitive Dysfunction
Impact of the Digital Multi-domain Cognitive Intervention in High-risk Populations for Dementia
Dementia is a chronic, progressive neurodegenerative disease characterized by acquired cognitive impairment as its core manifestation.
- Trial name
- NCT06442943
- Testing
- Multi-domain Cognitive Intervention
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Fujian Provincial Hospital
Alzheimer Disease
A Study to Evaluate the Safety, Tolerability, and Efficacy of TML-6 in Participants With Early Alzheimer's Disease
The primary purpose of the study is to assess if treatment with TML-6 for 52 weeks will be effective in slowing, stopping, or improving cognitive and functional decline in participants with early Alzheimer's Disease (AD) as…
- Trial name
- NCT07612150
- Testing
- TML-6
- Volunteers
- 210 people
- Sponsor
- Merry Life Biomedical Co., Ltd.
Cognitive Dysfunction
Cognitive Leisure and Preclinical Alzheimer's Disease: Exploring Neural Mechanisms
The goal of this clinical trial is aims to: 1. Translate and culturally adapt the Cognitive Leisure Activity Scale (CLAS) into Chinese and Conduct reliability and validity tests for the Chinese version of CLAS. 2.
- Trial name
- NCT06215274
- Testing
- Relationship of the cognitive leisure activity levels, cognitive function, and MRI characteristics.
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Yuanjiao Yan
Cognition
Impact of NANO-PSO on Cognition in Older Adults with Mild to Moderate Cognitive Impairment
The objective of this randomized, triple-blind, placebo-controlled clinical trial is to compare NANO-PSO therapy against placebo in improving cognitive abilities in older adults with mild to moderate non-vascular cognitive…
- Trial name
- COGMEG5 (NCT06520878)
- Testing
- NANO-PSO (pomegranate seed oil)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Distribuidora Biolife SA de CV
Memory, Cognitive Function
Effect of Daily Mixed Spice Consumption on Memory Function
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function.
- Trial name
- NCT06889961
- Testing
- Mixed spices
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cognitive Decline, Cognitive Impairment
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1…
- Trial name
- EFFECT (NCT06223672)
- Testing
- Walnuts, Simply White Diary-free chocolate bar
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Ohio State University
Stroke, Action Speed
Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease
A large series of recent studies have documented the frequency of the slowing of the action in brain diseases, especially vascular and neurodegenerative diseases.
- Conditions
- Stroke, Action Speed, Dementia Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- QTOAS (NCT05785156)
- Testing
- quick tests
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment
CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial
Obstructive sleep apnea (OSA) is a prevalent condition that significantly impacts the sleep health and overall well-being of millions of adults worldwide.
- Trial name
- CRESCENDO (NCT06983769)
- Testing
- MAD, CPAP
- Where
- Singapore
- Volunteers
- 260 people
- Sponsor
- National University Hospital, Singapore
Hearing Loss, Cognitive Impairment
Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment
Hearing loss and cognitive impairment are common and interrelated health problems that may affect communication, information processing, attention, psychological well-being, daily functioning, and quality of life.
- Trial name
- A-COP (NCT07869745)
- Testing
- Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Taipei Medical University
Cognitive Impairment, Preoperative Cognitive Impairment
Reliability In Neurocognitive Telemedicine Screening (RING)
Perioperative neurocognitive disorders are common after surgery and pre-existing cognitive impairment is an important risk factor.
- Conditions
- Cognitive Impairment, Preoperative Cognitive Impairment, Perioperative Neurocognitive Disorders, Neurocognitive Function
- Trial name
- NCT07760545
- Testing
- Modified Mini-Cog Telephone Assessment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of British Columbia
Mild Cognitive Impairment (MCI)
Cognitive-motor Training in Community-dwelling Older People With Mild Cognitive Impairment
As the global population ages, the prevalence of mild cognitive impairment (MCI) among older adults, which ranges from 5% to 40%, is expected to rise.
- Trial name
- NCT07241598
- Testing
- Smart±step cognitive-motor training
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Mahidol University
Alzheimer Disease, Mild Cognitive Impairment
The Swedish BioFINDER - Preclinical AD Study
This research study aims to examine biomarkers of Alzheimer's disease (AD) as early as possible which could potentially be a screening tool for the general population.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Mild Dementia
- Trial name
- NCT06121544
- Testing
- Plasma tau, Plasma β-Amyloid 42/40 (Aβ42/Aβ40), Flutemetamol F18 Injection
- Where
- Sweden
- Volunteers
- 800 people
- Sponsor
- Skane University Hospital
Cognitive Impairment
Cognitive Remote Assessment Using FLAME (CRA-FLAME)
We aim to use a multimodal approach comprising conventional neuropsychological cognitive tests, fluid and imaging biomarker data, to explore their association with the FLAME unsupervised cognitive computerized assessment.
- Trial name
- NCT05624632
- Testing
- Remote cognitive testing
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Mild Cognitive Impairment, Walking
Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment
The goal of this randomised clinical trial is to investigate the effectiveness of an innovative therapeutic exercise program emphasizing in dual-task exercises in people with amnestic Mild Cognitive Impairment.
- Conditions
- Mild Cognitive Impairment, Walking, Balance, Cognition
- Trial name
- MExeProMCI (NCT07334392)
- Testing
- Innovative therapeutic exercise program, Therapeutic exercise program, Flyer
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- University of Patras
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.