Clinical trials: Cognitive Dysfunction, open to volunteers
Cognitive Dysfunction, Overweight and Obesity
Cognitive Effects of Hesperidin in Overweight/Obese Older Adults
A randomized, double-blind, placebo-controlled trial was designed to test whether two doses of hesperidin (a natural flavonoid from citrus fruits) improve cognitive function in overweight and obese older adults.
- Trial name
- NCT07750223
- Testing
- Hesperidin
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Min Hou
Major Depressive Disorder (MDD), Neuroimaging
Efficacy of Bright Light Therapy on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms: Protocol for a Randomised Controlled Trial
This study aims to validate the therapeutic efficacy and safety of bright light therapy (BLT) in ameliorating cognitive impairment (CI) in major depressive disorder (MDD), characterize the functional and structural features of…
- Conditions
- Major Depressive Disorder (MDD), Neuroimaging, Bright Light Treatment, Cognitive Impairment
- Trial name
- NCT07508215
- Testing
- BLT, DRL
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Mild Cognitive Impairment, Chronic Kidney Diseases
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
The purpose of this study is to see if 6 months of home-based walking will improve memory, and brain structure and function, compared to health education in older adults that have chronic kidney disease and mild cognitive…
- Trial name
- EXEC (NCT05655325)
- Testing
- Home-based walking exercise, Attention control
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Columbia University
Schizophrenia, Cognitive Impairment
Functional Magnetic Resonance Imaging Study in Schizophrenia Patients and Correlation With Cognitive Impairments
1. Comparison of functional activity at different brain areas related to different cognitive domains e.g. Memory, visuospatial abilities, executive functions, attention, concentration, language, orientation in schizophrenia to…
- Trial name
- NCT06471179
- Testing
- Functional MRI
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Obstructive Sleep Apnea, Sleep Disorder
Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy
This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder, Well-Being, Psychological, Cognitive Impairment
- Trial name
- MULTI-OSAS (NCT06312956)
- Testing
- Continuous Positive Airway Pressure Ventilotherapy
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Istituto Auxologico Italiano
Cognitive Impairment
Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
This study primarily evaluates whether iEV nasal administration can improve neurological impairment and cognitive dysfunction in patients with acute cerebral infarction and cognitive impairment, and preliminarily explores its…
- Trial name
- NCT07145294
- Testing
- iEV, Basic treatments
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Hongmei Wang
Lewy Bodies Disease, Alzheimer Disease
Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach
Dementia with Lewy body disease (DLB) is the second leading cause of degenerative cognitive disorder after Alzheimer's disease (AD). Its variable clinical expression makes diagnosis difficult.
- Conditions
- Lewy Bodies Disease, Alzheimer Disease, Cognitive Impairment
- Trial name
- EEG-EDELY (NCT06068361)
- Testing
- EEG
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Long COVID, Post-COVID Conditions
Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue
Long COVID can cause persistent symptoms such as fatigue, cognitive difficulties commonly described as brain fog, reduced exercise tolerance, and impaired quality of life.
- Conditions
- Long COVID, Post-COVID Conditions, Fatigue, Cognitive Dysfunction
- Trial name
- NEUROSTIM-LC (NCT07709234)
- Testing
- Transcranial Direct Current Stimulation
- Volunteers
- 20 people
- Sponsor
- University of Las Palmas de Gran Canaria
Vascular Cognitive Impairment, Mild Cognitive Impairment
Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)
People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory.
- Trial name
- EXPRESS-V (NCT05079464)
- Testing
- tDCS, Exercise, Treatment as usual
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Sunnybrook Health Sciences Centre
Post-Intensive Care Syndrome (PICS), Critical Illness
Inflammatory and Genetic Predictors of Cognitive and Emotional Recovery After Critical Illness
Survivors of critical illness frequently develop persistent cognitive and emotional impairments, known as post-intensive care syndrome (PICS), which substantially impact quality of life and long-term recovery.
- Trial name
- CORE-ICU (NCT07659431)
- Volunteers
- 114 people
- Sponsor
- Corporacion Parc Tauli
Post-stroke Cognitive Impairment
Edaravone Dexborneol Sublingual Tablet for the PSCI in Acute Ischemic Stroke Patients
This is a multicenter, randomized, double-blind, placebo-controlled, exploratory Phase II clinical trial. The goal of this clinical trial is to assess the safety and efficacy of edaravone dexborneol sublingual tablets for…
- Trial name
- NCT06315231
- Testing
- Edaravone dexborneol sublingual tablet
- Where
- 21 sites in China
- Volunteers
- 226 people
- Sponsor
- Simcere Pharmaceutical Co., Ltd
Ovarian Cancer, Cognitive Impairment
Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT
This is a phase I, dose-escalation and phase II dose-expansion clinical trial determining the maximum tolerated dose (MTD) and safety and tolerability of adding N-Acetyl-Cysteine (NAC) to ovarian cancer patients who are receiving…
- Trial name
- NCT04520139
- Testing
- N-Acetyl-Cysteine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Irvine
Post-Stroke Cognitive Impairment (PSCI), Repetitive Transcranial Magnetic Stimulation (rTMS)
High-Frequency Repetitive Transcranial Magnetic Stimulation for Cognitive Improvement in Patients With Post-Stroke Cognitive Impairment
To clarify the clinical efficacy of high-frequency rTMS on patients with post-stroke cognitive impairment, fNIRS and EEG techniques were used to observe the changes in brain functional activities of patients with post-stroke…
- Conditions
- Post-Stroke Cognitive Impairment (PSCI), Repetitive Transcranial Magnetic Stimulation (rTMS), Stroke
- Trial name
- NCT07546877
- Testing
- repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Alzheimer Disease
Efficacy and Safety of NVP-NK4146 in Patients With Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
The purpose of this clinical trial is to exploratively evaluate the efficacy and safety of NVP -NK4146 in improving mild cognitive impairment (MCI) in patients with due to Alzheimer's disease (AD) compared to placebo
- Trial name
- NCT06761066
- Testing
- NVP-NK4146
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- NVP Healthcare
Mild Cognitive Impairment (MCI)
Evaluation of the Impact of Medium-chain Fatty Acids in the Evolution of Newly Diagnosed Mild Cognitive Impairment
Mild cognitive impairment (MCI) is considered the intermediate stage between the changes observed in physiological aging and dementia.
- Trial name
- MCI-MCT (NCT06951932)
- Testing
- Mediterranean-type diet with MCT supplementation, Mediterranean-type food regimen using extra virgin olive oil
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Alzheimer Disease, Mild Cognitive Impairment
BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers
This research study aims to examine biomarkers of Alzheimer's disease as early as possible which could potentially be a screening tool for the general population.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT05457998
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948 Injection, [18F]-MK-6240 Injection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Diabetes Mellitus, Type 2, Cognitive Dysfunction, Cognitive Disorder
Serum Sulfate and Brain Function in Diabetic Encephalopathy
The goal of this observational study is to learn about the relationship between sulfate ion levels in the blood and brain function in people with diabetic encephalopathy, a diabetes-related brain condition that can affect…
- Conditions
- Diabetes Mellitus, Type 2, Cognitive Dysfunction, Cognitive Disorder, Brain Diseases, Metabolic
- Trial name
- NCT07837258
- Testing
- This study does not involve any treatment or intervention.
- Volunteers
- 220 people
- Sponsor
- Dongzhimen Hospital, Beijing
Mild Cognitive Impairment (MCI)
Cognitive-motor Training in Community-dwelling Older People With Mild Cognitive Impairment
As the global population ages, the prevalence of mild cognitive impairment (MCI) among older adults, which ranges from 5% to 40%, is expected to rise.
- Trial name
- NCT07241598
- Testing
- Smart±step cognitive-motor training
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Mahidol University
Dementia, Cognitive Dysfunction
Preventing Loss of Independence Through Exercise in Community Living Centers
Approximately 40,000 older Veterans with complex care needs receive long-term care in VA Community Living Centers (CLCs). Many CLC staff have limited specialized training to engage Veterans with dementia.
- Trial name
- PLIE-CLC (NCT06972004)
- Testing
- Preventing Loss of Independence through Exercise (PLIE)
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis
ME/CFS Brain Fog: Cognitive Rehabilitation Trial
The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog.
- Conditions
- ME/CFS, ME/CFS Following EBV-associated Infectious Mononucleosis, ME/CFS Following COVID-19, Chronic Fatigue
- Trial name
- NCT07523113
- Testing
- Processing Speed Training, In-session Instrumental Activities of Daily Living Training, Transfer Package
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
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