Clinical trials: Cognitive Dysfunction, open to volunteers
Stroke, Action Speed
Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease
A large series of recent studies have documented the frequency of the slowing of the action in brain diseases, especially vascular and neurodegenerative diseases.
- Conditions
- Stroke, Action Speed, Dementia Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- QTOAS (NCT05785156)
- Testing
- quick tests
- Where
- France
- Volunteers
- 129 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Depressive Disorder, Major, Inflammation
Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab
This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in…
- Trial name
- NCT06136546
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment (MCI)
Medication Self-Management Technology for Older Adults
The goal of this feasibility study is to evaluate the preliminary impact of a mobile health application (app) called bpMedManage-R, designed to support hypertension medication self-management in persons with mild cognitive…
- Trial name
- NCT07754994
- Testing
- Immediate Intervention Arm, Delayed Intervention Arm
- Volunteers
- 40 people
- Sponsor
- University of Illinois at Urbana-Champaign
Age-Related Cognitive Decline
EMBRACE - From Vulnerable to Empowered: Implementation and Evaluation of a Multicomponent Program to Tackling Age-related Decline
EMBRACE is a randomized, controlled, multi-domain, blinded clinical trial involving 120 community-dwelling older adults at risk of cognitive decline, lasting 12 months.
- Trial name
- EMBRACE (NCT07628686)
- Testing
- EMBRACE Intervention
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Fernando Pessoa
Dementia, Alzheimer Type, Mild Cognitive Impairment
Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits.
- Conditions
- Dementia, Alzheimer Type, Mild Cognitive Impairment, Cardiac Amyloidosis
- Trial name
- NCT07154394
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital, Essen
Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder
The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery
RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive…
- Conditions
- Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder, Cardiac Surgery, Major Surgery Under General Anesthesia
- Trial name
- INOCS (NCT07200726)
- Testing
- Observational study design - no intervention
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Ziekenhuis Oost-Limburg
Mild Cognitive Impairment (MCI), Dementia
Telemedicine Self-examination of Speech and Memory for Rapid Detection of Cognitive Impairments Using Machine Learning Methods
Early cognitive disorders diagnosis is becoming increasingly important due to population aging. The most common causes include Alzheimer's disease and frontotemporal dementia.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Mild Cognitive Impairment (MCI) Amnestic, Frontotemporal Degeneration (FTD)
- Trial name
- NCT07558785
- Testing
- The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the Mississippi Aphasia Screening Test, Amnesia Light and Brief Assessment (ALBA)
- Where
- 3 sites in Czechia
- Volunteers
- 500 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mild Cognitive Impairment (MCI)
Multicomponent Intervention to Improve Cognitive Abilities in Older Adults With Mild Cognitive Impairment
The research aims to investigate the effectiveness of a new short-term multicomponent intervention to promote the bio-psycho-social-spiritual health of older adults with MCI to improve their cognitive abilities.
- Trial name
- MMI for MCI (NCT07549074)
- Testing
- Cognitive stimulation, Lifestyle Education, Multicomponent intervention
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Epilepsy, Quality of Life
Idiopathic Generalized Epilepsy Cognitive and Emotional Profile
The primary goal of the study is to explore the neurocognitive, emotional-behavioral functioning, and quality of life of adolescents with IGE, identifying key factors that affect their overall well-being.
- Conditions
- Epilepsy, Quality of Life, Neuropathology, Emotional Problem
- Trial name
- NCT06782074
- Testing
- emotional and neuropsychological assessment
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cognitive Impairment
Radialis PET Imager for the Assessment of Neuritic Amyloid Plaque Burden
The standard or usual workup for cognitive impairment, including Alzheimer's Disease, may include brain amyloid PET with PET/CT or PET/MR imaging.
- Trial name
- Amyloid RPI (NCT06757569)
- Testing
- PET
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University Health Network, Toronto
Mild Cognitive Impairment, Alzheimer Disease
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
This study focuses on assessing and measuring white matter hyperintensities in individuals with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease.
- Trial name
- NCT06179680
- Testing
- Magnetic Resonance Imaging
- Where
- Italy
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Parkinson Disease, Movement Disorders
Cognitive Decline Following Deep Brain Stimulation
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS.
- Trial name
- NCT05822388
- Testing
- Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Mild Cognitive Impairment, Cognitive Function
Binaural Beats for Cognitive Function in Older Adults With Mild Cognitive Impairment in Nursing Homes
This study will evaluate whether binaural beats can improve cognitive function in older adults with mild cognitive impairment living in nursing homes.
- Trial name
- BB-MCI (NCT07735910)
- Testing
- Binaural Beats Embedded in Old Songs, Old Songs
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- China Medical University, China
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Ischemic Stroke, Diabete Mellitus
DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes
Post-stroke cognitive impairment (PSCI) increases the risk of disability and mortality in stroke patients, thereby exacerbating the disease burden of stroke.
- Trial name
- NCT07241897
- Testing
- Sentagliptin Phosphate - single dose
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder
Aβ PET and Tau PET Imaging in the Diagnosis and Progression Assessment of Alzheimer's Disease
This prospective study recruited 20 healthy volunteers and 50 patients diagnosed with Alzheimer's disease (AD) and mild cognitive impairment (MCI) according to clinical guidelines.
- Conditions
- Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder, PET Imaging
- Trial name
- NCT07114224
- Testing
- AV45/AV-1、AV1451 PET
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Cognitive Impairment, Cognitive Impairment, Mild
Comparative Evaluation of Immediate vs Progressive Standing Dual Task Training in Elderly With Mild and Moderate Cognitive Impairment
older adults with mild and moderate cognitive impairment. compare immediate vs progressive standing dual-task training. assess balance, cognition, executive function, mobility, and quality of life.
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Moderate Cognitive Impairment
- Trial name
- NCT07764250
- Testing
- Immediate standing dual task training, progressive standing dual task training
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- Shifa Tameer-e-Millat University
Subjective Cognitive Decline (SCD), Subjective Cognitive Decline
Chinese Classics Recitation Training in Subjective Cognitive Decline
Subjective cognitive decline (SCD) is considered a preclinical condition associated with an increased risk of dementia and Alzheimer's disease.
- Trial name
- NCT07463391
- Testing
- Memory training by Chinese Classics recitation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
Mild Cognitive Impairment, Alzheimer Disease, Late Onset
Multimodal Assesment of Alzheimer Patients
The goal of this study is to learn more about the changes in the brains of patients with cognitive impairment (MCI) and Alzheimer's Disease (AD). The main questions the study aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Late Onset, Cognitive Impairment, Dementia
- Trial name
- MultiAD (NCT06448403)
- Testing
- MRI Scanning, 64-channel EEG, Polysomnography
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
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