Clinical trials: Cognitive Dysfunction, open to volunteers
Brain Diseases, Epilepsy
Amygdala Memory Enhancement
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories.
- Conditions
- Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury
- Trial name
- NCT05065450
- Testing
- Intracranial Stimulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Stroke
Motor-Cognitive Interactive Upper Limb Robot Rehabilitation for Post-Stroke Motor Dysfunction
This study aims to investigate the effects of motor-cognitive interactive robot-assisted training on improving upper limb motor dysfunction after stroke.
- Trial name
- NCT06876597
- Testing
- Motor-cognitive interactive robot, Motor-focused robot, Conventional rehabilitation training
- Where
- China
- Volunteers
- 1,047 people
- Sponsor
- Lidian Chen
Sickle Cell Disease, Cognitive Impairment
Cognitive Remediation Intervention to Prepare for Transition of Care
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for…
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy
- Trial name
- NCT05336201
- Testing
- CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Impairment, Psychological
Psychological Treatment to Support the Consequences of Cognitive Impairment
The burden of cognitive impairment is severe, and often hinders affected people to act independently in daily life. Individuals in different stages of cognitive decline are frequently affected by existential distress and…
- Conditions
- Cognitive Impairment, Psychological, Psychotherapy, Health Behavior
- Trial name
- NCT04356924
- Testing
- Psychological treatment, Cognitive training
- Where
- Sweden
- Volunteers
- 138 people
- Sponsor
- Karolinska Institutet
Cognitive Dysfunctions, Cognitive Disorder
Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly With Mild Cognitive Impairment
One of the key challenges faced by individuals with Mild Cognitive Impairment (MCI) is the decline in cognitive abilities, particularly global cognition, attention, and executive function, which are essential for maintaining…
- Conditions
- Cognitive Dysfunctions, Cognitive Disorder, Cognitive Decline
- Trial name
- NCT07242495
- Testing
- VR 360 degree Videos and Aerobic Chair Exercises intervention, Chair Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Advanced ALK/ROS1-positive NSCLC, Carcinoma, Non-Small-Cell Lung (NSCLC)
Vortioxetine for Cognitive Function in ALK-positive NSCLC Treated With Lorlatinib
This observational study evaluates whether vortioxetine - an antidepressant medication with cognitive-enhancing properties - can reduce the neurological and cognitive side effects associated with lorlatinib treatment in patients…
- Conditions
- Advanced ALK/ROS1-positive NSCLC, Carcinoma, Non-Small-Cell Lung (NSCLC), Lung Adenocarcinoma, ALK-positive Non-small Cell Lung Cancer (NSCLC)
- Trial name
- NCT07633626
- Where
- Colombia
- Volunteers
- 24 people
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Agitation, POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE
PARO-agitation-study
Postoperative agitation is a common and serious complication in visceral and transplant surgery, associated with prolonged hospital stays and an increased risk of self-harm.
- Conditions
- Agitation, POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Anxiety After Surgery, Postoperative Pain
- Trial name
- NCT07568093
- Testing
- PARO
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Hannover Medical School
Epilepsy, Cognitive Dysfunction, Cognitive Disorder
HOBSCOTCH-YOUTH and Young Adults
The goal of this clinical trial is to learn more about the home-based epilepsy self-management program, HOBSCOTCH, for improving cognitive function (thinking and memory) and quality of life specifically in young adults, ages 18 …
- Conditions
- Epilepsy, Cognitive Dysfunction, Cognitive Disorder, Memory and Thinking Problems
- Trial name
- NCT07735715
- Testing
- HOBSCOTCH/HOBSCOTCH-YOUTH
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Sexual Dysfunction
Developing a Psychosexual Education App With Artificial Intelligence
The goal of this clinical trial is to establish the effectiveness of a resource based educational psychosexual app for patients attending a waiting list for psychosexual therapy.
- Trial name
- NCT07152847
- Testing
- Psychosexual education app with artificial intelligence
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London Metropolitan University
Alzheimer Disease, Mild Cognitive Impairment
Software Validation Study-Cognitive Status Indicator
The SPARK Cognitive Status Indicator software uses an algorithm to assess a resting state EEG recording as being consistent with a cognitive status of unimpaired, mild cognitive impairment (MCI; MCI AD- or MCI AD+), or dementia…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- REMIND-V (NCT06809725)
- Testing
- SPARK Cognitive Status Indicator (software support data collected via EEG)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Spark Neuro Inc.
Late-Life Depression
Effects of Specific Amino Acid Supplementation and Lifestyle Factors on Brain Ageing
The aim of this clinical trial is to investigate the effects of L-serine supplementation on cognitive decline and psychosocial functioning in older adults with late-life depression (LLD).
- Trial name
- AAAgeing (NCT07497347)
- Testing
- L-serine supplementation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Postoperative Delirium, Cerebral Oxygen Saturation
Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation
This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium…
- Conditions
- Postoperative Delirium, Cerebral Oxygen Saturation, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- NCT07399184
- Testing
- ibuprofen
- Volunteers
- 54 people
- Sponsor
- Ondokuz Mayıs University
Brain Tumors, Epilepsy
Quality Improvement and Practice Based Research in Neurology Using the EMR
The investigators will conduct at NorthShore University HealthSystem pragmatic trials using the EMR for 10 common neurological disorders.
- Conditions
- Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment
- Trial name
- NCT02670161
- Testing
- Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description)
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Endeavor Health
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
Improving Dementia Care in Primary Practice
This clinical trial will evaluate a multi-level scalable intervention called Improving Dementia Care (IDC). The investigators hypothesize that IDC will increase dementia detection in patients with impaired cognition more than the…
- Conditions
- Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia
- Trial name
- IDC (NCT07526480)
- Testing
- Improving Dementia Care, Enhanced Usual Care
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Congestive Heart Failure Chronic, Cognitive Impairment, Mild
Depressive Symptoms, Cognitive Impairment, and Outcomes in Hospitalized Chronic Heart Failure Patients
The goal of this observational study is to learn about the prevalence of depressive symptoms and cognitive impairment and their association with worse outcomes in a cohort of hospitalized patients between the ages of 18 ang 85…
- Conditions
- Congestive Heart Failure Chronic, Cognitive Impairment, Mild, Depressive Symptoms Mild to Moderate in Severity
- Trial name
- DSCI-CHF (NCT07284446)
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Lithuanian University of Health Sciences
Chemo Brain
Edaravone and Dexborneol Sublingual Tablet for Treating Chemotherapy- Induced Cognitive Impairment Study
Chemotherapy-induced cognitive impairment (CICI), also known as "chemobrain," is a range of neurocognitive deficits experienced during and after cancer chemotherapy.
- Trial name
- EDS-CICI (NCT07454473)
- Testing
- Edaravone Dexborneol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chuansheng Zhao
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI
Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation.
- Conditions
- Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis
- Trial name
- KDROP-MCI (NCT07417891)
- Testing
- Well-formulated ketogenic diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Dementia Disorder
German Dementia Registry
The German Dementia Registry (DEMREG) is a large-scale national prospective biomarker-based study for cognitive impairment and dementia, providing an integrated clinical research platform for research studies.
- Trial name
- DemReg (NCT07433010)
- Testing
- This is a registry.
- Where
- 24 sites in Germany
- Volunteers
- 5,000 people
- Sponsor
- RWTH Aachen University
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
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