Clinical trials: Cognitive Dysfunction, open to volunteers
CABG, PCI
The CDAC Study - Cerebral Dysfunction After Coronary Revascularization
Neurocognitive decline has long been suspected to be a potential long-term complication of coronary artery bypass grafting surgery (CABG), with reports of post-operative cognitive dysfunction by objective testing approaching…
- Conditions
- CABG, PCI, Cognitive Decline
- Trial name
- CDAC (NCT07491120)
- Testing
- Neurocognitive testing
- Volunteers
- 600 people
- Sponsor
- The Scripps Research Institute
Alzheimer Disease, Mild Cognitive Impairment
Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03851523
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Neurocognitive Dysfunction
Evaluation of Memantine in the Preservation of Memory and Neurocognition Following CSI
The goal of this clinical trial is to evaluate the role of memantine in preservation of memory and neurocognition in patients undergoing craniospinal irradiation.
- Trial name
- MEMENTO (NCT06275035)
- Testing
- Memantine Oral Tablet
- Where
- India
- Volunteers
- 101 people
- Sponsor
- Tata Memorial Centre
Post-stroke, Parkinson Disease
Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients
The purpose of this clinical study is to evaluate the feasibility, usability, and motivational impact of VirtualPark, a virtual reality-based dual-task rehabilitation system, in adults with neurological and age-related…
- Conditions
- Post-stroke, Parkinson Disease, Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment (MCI)
- Trial name
- VP_Adults (NCT07616050)
- Testing
- Dual-task training with Virtual Reality, Cycling training
- Where
- 7 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Marta Mondellini
Cerebral Small Vessel Disease, Stroke
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries.
- Conditions
- Cerebral Small Vessel Disease, Stroke, Cognitive Complaint
- Trial name
- SHIVA-CogNeuro (NCT07068620)
- Testing
- Home-based cognitive training
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Post Intensive Care Syndrome (PICS)
Post Intensive Care Accelerometery to Study and Support Recovery Outcomes
The primary purpose of this study is to find out whether a wrist-worn activity monitor can help healthcare professionals understand how people recover after they leave the intensive care unit (ICU), where they were cared for when…
- Trial name
- PICASSO (NCT07466446)
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Cerebral Small Vessel Disease, Vascular Cognitive Impairment
Personalized Intermittent Theta Burst Stimulation for Cognitive Impairment Related to Cerebral Small Vessel Disease
This study will evaluate whether personalized intermittent theta burst stimulation (iTBS), a form of noninvasive transcranial magnetic stimulation, can safely improve cognitive function in people with cognitive impairment related…
- Trial name
- NCT07891650
- Testing
- Active Personalized Intermittent Theta Burst Stimulation
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson Disease, Cognitive Impairment
Theta Deep Brain Stimulation for Cognitive Enhancement in Parkinson's Disease
Cognitive impairment is common in Parkinson's disease. A recent study demonstrated 40% of people with PD suffer from mild cognitive impairment and > 80% of patients develop dementia after a disease duration of 20 years.
- Trial name
- NCT06518824
- Testing
- DBS On, DBS Off
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Vestibular Dysfunction, Dizziness
Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks
This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same…
- Conditions
- Vestibular Dysfunction, Dizziness, Falls (Accidents) in Old Age, Balance Assessment
- Trial name
- NCT07735078
- Testing
- Instrumented balance and gait assessment using wearable inertial sensors, Questionnaires and paper-based cognitive tests
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Aging, Inflammation
Cognitive Remediation
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in…
- Conditions
- Aging, Inflammation, Cognitive Remediation, Cognitive Dysfunction
- Trial name
- NCT07171450
- Testing
- Computerized Cognitive Remediation, Alternative Computer Activities
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cutter Lindbergh
Heart Failure With Reduced Ejection Fraction
Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients
Cognitive impairment (CI) is highly prevalent in patients with heart failure with reduced ejection fraction (HFrEF), which has significant implications for disease management, quality of life and clinical outcomes.
- Trial name
- LYRIC-HF (NCT07695090)
- Testing
- Lumacaftor 200 MG
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Qanatpharma AG
Sepsis, Sepsis Associated Encephalopathy
EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes
To characterize the electroencephalogram (EEG) features of sepsis patients with distinct inflammatory response phenotypes, dynamically track their evolutionary trajectories, and analyze their associations with long-term changes…
- Conditions
- Sepsis, Sepsis Associated Encephalopathy, Sepsis and Septic Shock, Sepsis at Intensive Care Unit
- Trial name
- NCT07760415
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Xiangya Hospital of Central South University
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Severe Acute Malnutrition, Cognitive Impairment
Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition
The goal of this clinical trial is to test the use of milk fat globule membrane (MFGM) in ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition in Sierra Leone.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Kwashiorkor, Severe Wasting
- Trial name
- MEND-SAM (NCT06869850)
- Testing
- MFGM-RUTF (milk fat globule membrane ready-to-use therapeutic food), S-RUTF (standard ready-to-use therapeutic food), Amoxicillin
- Where
- 10 sites in Sierra Leone
- Volunteers
- 1,600 people
- Sponsor
- Washington University School of Medicine
Cognitive Impairment, Dementia
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for…
- Conditions
- Cognitive Impairment, Dementia, ADD, Depression
- Trial name
- NCT05927974
- Testing
- Passive testing, Active testing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Anesthesia, Neuroinflammation
Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study
This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors.
- Conditions
- Anesthesia, Neuroinflammation, Cognitive Disorders
- Trial name
- NCT07388160
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Atrial Fibrillation
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
The DaRe2 approach (healthcare Data for pragmatic clinical Research in the NHS - primary 2 secondary) is designed to operationalise efficient, nationwide, primary care approaches for randomised trials embedded within the UK…
- Trial name
- DaRe2THINK (NCT04700826)
- Testing
- Direct Oral Anticoagulants
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- University of Birmingham
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Mild Cognitive Impairment, Alzheimer Disease
Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers
This study evaluates a diagnostic screening solution for Alzheimer's disease (AD) using digital cognitive assessments and blood-based biomarkers.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- NCT07041450
- Testing
- Digital MoCA, XpressO, MoCA
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- MoCA Clinic and Institute
Frailty at Older Adults, Mild Cognitive Impairment
A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity…
- Trial name
- TMS MRI TBS (NCT07497334)
- Testing
- Theta burst stimulation, Aerobic exercise
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- The Hong Kong Polytechnic University
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