Clinical trials: Cognitive Dysfunction, open to volunteers
Alzheimer Disease, Mild Alzheimer Disease
Repurposing Siponimod for Alzheimer's Disease
Collaboration with multiple sclerosis (MS) specialty colleagues led us to formulate the central hypothesis that Siponimod could lower the rate of brain atrophy in Alzheimer's disease (AD) subjects.
- Conditions
- Alzheimer Disease, Mild Alzheimer Disease, MCI With Increased Risk for Alzheimer Disease, Cognitive Impairment, Mild
- Trial name
- SIPO1-AD (NCT06639282)
- Testing
- Siponimod
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Insomnia, Mild Cognitive Impairment
SleepSMART for Veterans With Insomnia and Mild Cognitive Impairment
Insomnia is a transdiagnostic health problem affecting the physical, cognitive, emotional, and social functioning of Veterans. Importantly, chronic insomnia may be a modifiable risk factor for progression to serious health…
- Trial name
- SleepSMART (NCT07397182)
- Testing
- Cognitive BehavioralTherapy for Insomnia (CBT-I), SleepSMART
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Chinese University-Alzheimer's Disease With Vascular and Other Co-pathology: Towards Actionable Neuro-Cognitive-Omic Evaluations (CU-ADVANCE)
Population aging is transforming the epidemiological landscape of the Asia-Pacific region at an unprecedented pace. By 2050, more than one quarter of the region's population will be aged over 60, with 36.7% of countries projected…
- Trial name
- NCT07917182
- Where
- China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Alzheimer Disease, Dementia
Jigsawdio Multisensory Platform for People With Mild Cognitive Impairment, Alzheimer's Disease, or Related Dementias
This study will evaluate Jigsawdio, a personalized multisensory jigsaw puzzle platform, for adults aged 60 years and older with mild cognitive impairment or mild dementia.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment
- Trial name
- NCT07839286
- Testing
- Jigsawdio Multisensory Puzzle Platform, Standard Jigsaw Puzzle Activity
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Callahan-Young LLC DBA Jigsawdio
Dementia
The Exercogs® Study
Background: Multidomain, technology-based interventions represent a promising approach to dementia prevention by simultaneously targeting cognitive, physical, and social domains.
- Trial name
- Exercogs (NCT07530315)
- Testing
- Exercogs®, Control
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Eduarda Oliosi, MS
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Pain, Chronic, Dementia, Mild
Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia
The purpose of this study is to develop an exercise treatment program for knee osteoarthritis that works well for people with memory problems. This study will include two parts.
- Conditions
- Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability
- Trial name
- NCT06264362
- Testing
- Tailored Physical Activity Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Drexel University
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer Disease
A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
The primary purpose of this study is to evaluate the safety and tolerability of Zunveyl® over 12 weeks of routine clinical use in adults with mild to moderate Alzheimer's disease.
- Trial name
- RESOLVE (NCT07633470)
- Testing
- Zunveyl®
- Where
- 22 sites in United States
- Volunteers
- 150 people
- Sponsor
- Alpha Cognition, Inc
Major Depressive Disorder, Bipolar Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS).
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
- Trial name
- NCT06897670
- Testing
- Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Alzheimer s Disease, Major Depressive Disorder (MDD)
VR Pupillometry in Cognitive Impairment
With disease-modifying therapies emerging for dementia and related conditions, identifying cognitive decline as early as possible is increasingly important.
- Conditions
- Alzheimer s Disease, Major Depressive Disorder (MDD), Mild Cognitive Impairment, Dementia
- Trial name
- NCT07402356
- Where
- Germany
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Max-Planck-Institute of Psychiatry
Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and…
- Trial name
- NCT07483151
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POCD assessments
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhuan Zhang
Insulin Resistance, Mild Cognitive Impairment
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
This randomized, double-blind, placebo-controlled, 8-week clinical trial is designed to evaluate the effects of Sabroxy®, a standardized extract of Oroxylum indicum bark, on insulin resistance and cognitive function in adults…
- Conditions
- Insulin Resistance, Mild Cognitive Impairment, Cognitive Decline, Neurodegenerative Disorders
- Trial name
- NCT07220694
- Testing
- Sabroxy®
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- SF Research Institute, Inc.
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Stroke, Cognitive Impairment
A Sitting Tai Chi Programme for Chronic Stroke Survivors With Post-stroke Cognitive Impairment
Introduction Stroke remains the third leading cause of death and disability combined. Post-stroke cognitive impairment (PSCI) is a common neurological sequela that may affect up to 80% of stroke survivors.
- Trial name
- NCT07512739
- Testing
- Tai Chi
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Cognitive Impairment
Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses
The goal of this randomized controlled clinical trial is to learn if a couple-centered cognitive intervention program can improve cognitive health, reduce caregiving burden, and support overall well-being for community-dwelling…
- Trial name
- NCT07872189
- Testing
- Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Gansu University of Chinese Medicine
Aging, Inflammation
Cognitive Remediation
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in…
- Conditions
- Aging, Inflammation, Cognitive Remediation, Cognitive Dysfunction
- Trial name
- NCT07171450
- Testing
- Computerized Cognitive Remediation, Alternative Computer Activities
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cutter Lindbergh
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
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