Clinical trials: Cognitive Enhancement
Psychosis
Adaptation of Cognitive Enhancement Therapy for Persons at Clinical High Risk for Psychosis
The purpose of this study is to test the feasibility of a modification of CET (Cognitive Enhancement Therapy) to address symptomatic and functional difficulties associated with Clinical High Risk for Psychosis (CHR).
- Trial name
- CLUES (NCT02459210)
- Testing
- CLUES, therapy and computer games
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cognition
Investigating the Effects of a Haskap Berry Supplement on Cognitive Health
This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+.
- Trial name
- HACVAC (NCT07119788)
- Testing
- Pure haskap berry powder, Vitamin-and mineral-enhanced haskap berry powder
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Reading
Multiple Sclerosis, Performance Enhancement
Effects of DHA in Patients With Multiple Sclerosis
This clinical trial will investigate the effects of combining therapeutic exercise with DHA supplementation in 100 patients with multiple sclerosis using a randomized controlled design.
- Conditions
- Multiple Sclerosis, Performance Enhancement, Supplemental Nutrition Assistance Program Education, Strength Outcomes
- Trial name
- DHAME (NCT07346703)
- Testing
- Docosahexaenoic Acid (DHA) Dietary Supplement, Sunflower Oil
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Presymptomatic Disease, Mild Cognitive Impairment
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
The study is carried out as part of the GR2021 Priority project "Healthy Brains for life (Age 20-99): Digitally-enhanced personalized medicine study ANANEOS" and code numbered GR-00546 and it will look at the decentralized and…
- Conditions
- Presymptomatic Disease, Mild Cognitive Impairment, Memory Loss (Excluding Dementia), Cognitive Change
- Trial name
- ANANEOS (NCT04701177)
- Testing
- Teleph0s digital phenotyping platform
- Where
- 4 sites in Greece, Spain
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Greece 2021 Committee
Schizophrenia
Cognitive Training and Enhanced Supported Employment in Schizophrenia
This study will evaluate the effectiveness of a computer-based cognitive enhancement program plus a work therapy program at improving productivity, work performance, and quality of life in schizophrenic individuals.
- Trial name
- NCT00339170
- Testing
- Computer-Based Cognitive Enhancement Training Program, Work Therapy Program
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Yale University
ICU Survivors
Integrated Recovery Program for Critical Illness
This study aims to investigate the effects of the Integrated Critical Illness Aftercare and Recovery Enhancement (I-CARE) program on reducing healthcare burden and improving functional outcomes in ICU survivors.
- Trial name
- iCARE (NCT06997822)
- Testing
- LINE Bot-Based Remote Care Combined with In-Person Post-ICU Clinic
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Schizophrenia, Schizoaffective Disorder
Pharmacologic and Clinical Testing of a D1 Agonist for Cognitive Enhancement in Neuropsychiatric Disorders
The investigators propose to recruit individuals with schizophrenia who are symptomatically stable and already taking medications to participate in this study.
- Trial name
- NCT01519557
- Testing
- DAR-100A
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- New York State Psychiatric Institute
Multiple Sclerosis, Encephalitis
tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities in individuals with multiple sclerosis (MS) or encephalitis.
- Trial name
- NCT02538094
- Testing
- Anodal Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Cognitive Impairment, Mild, Quality of Life
Virtual Reality Stimulation to Enhance Cognitive Function of Intensive Care Unit Patients
An observational study will be conducted in the ICU (Intensive care unit) including patients with heart surgery (< 5 days) and prolonged ICU stay (> 5 days). Patients will receive 5 min Virtual reality stimulation per day.
- Trial name
- NCT03025373
- Testing
- Visuo-acoustic stimulation
- Where
- Switzerland
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Mild Cognitive Impairment
Applying a Person-Centered Approach to Enhance Cognitive Training in Senior Living Community Residents With Mild Cognitive Impairment
Computerized cognitive interventions (CCIs) have been increasingly widely implemented among older adults with mild cognitive impairment (MCI).
- Trial name
- CogT-PACT (NCT03292705)
- Testing
- PEP, CCI
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Neurobehavioral Manifestations
Prophylaxis Against Malaria to Enhance Child Development (PROTECT Study)
Each year, ~85.3 million pregnant women are at risk of becoming infected with Plasmodium falciparum(1). Among women in sub-Saharan Africa, most of whom have some degree of clinical immunity to malaria, malaria infection in…
- Trial name
- PROTECT (NCT02557425)
- Testing
- No intervention in PROTECT
- Where
- Uganda
- Volunteers
- 272 people
- Sponsor
- Indiana University
Cognitive Impairment, Diet Interventions
The Resistant Starch Intervention for Cognitive Enhancement
The investigation will explore the potential effects of resistant starch The Resistant Starch Intervention for Cognitive Enhancement study aimed to evaluate the effect of high-resistant starch diet intervention in slowing…
- Conditions
- Cognitive Impairment, Diet Interventions, Cognitive Decline, Genetic Risk Factors
- Trial name
- NCT07152483
- Testing
- High resistant starch staple foods, Regular starch staple foods
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alzheimer's Disease
Enhancing Working Memory in Patients With Early Alzheimer's Disease Through the Use of rTMS
In this study the investigators aim at assessing and then enhancing neuroplasticity in the dorsolateral prefrontal cortex (DLPFC) and working memory - a key function of DLPFC - in patients with mild Alzheimer's disease (AD).
- Trial name
- rTMS-AD (NCT02537496)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Diabetes Mellitus, Type 2, Cognitive Dysfunction, Epigenetics, Exercise
Using Polar Unite Fitness Watch to Improve Cognition for T2DM Patients
Type 2 diabetes mellitus (T2DM) impairs the brain, leading to cognitive dysfunction, which carries substantial lifetime consequences.
- Trial name
- NCT04603885
- Testing
- Aerobic exercise program, Stretching exercise
- Volunteers
- 42 people
- Sponsor
- University of Arkansas, Fayetteville
Physical Functional Impairment, Cognitive Impairment
Community Recreation to Enhance Function in Aging
This aim of this study is to examine the therapeutic impacts of a group-based recreational program that delivers guided visual artmaking and dual-task exergaming, to older adults.
- Trial name
- NCT07104435
- Testing
- Artmaking and exergaming
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Healthy Volunteer, HV
High-Density Direct Current Brain Polarization
Background: Direct current (DC) brain polarization is a technique in which very weak electricity is applied to the head. Doctors have used DC polarization for many years on patients and healthy people with no known serious side…
- Trial name
- NCT00944931
- Testing
- DC Brain Polarization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Anxiety, Fear Extinction
Uncovering Neurocognitive Mechanisms and Enhancement of Exposure-based Fear Learning With Cognitive Training
Anxiety disorders remain are among the most prevalent psychiatric conditions and are associated with negative outcomes spanning poor health to increased suicide risk.
- Trial name
- NCT07805070
- Testing
- Cognitive training
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Hip Fractures, Cognitive Impairment
Optimized Rehabilitation of Older Adults With Hip Fracture and Signs of Cognitive Impairment - Feasibility Study
Older adults suffering from a hip fracture are a significant concern, with higher incidence rates among women. Mortality rates post-hip fracture are alarming, with up to 8-fold increased risk within 3 months and significant…
- Trial name
- ENHANCE (NCT06286722)
- Testing
- Progressive, individualized and structured exercise program
- Where
- 6 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Lolland Community, Denmark
Cognitive Impairment, no Dementia (CIND)
ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement
ENLIGHTEN will examine the effects of exercise, the dietary approaches to stop hypertension diet (DASH), and a combined exercise and DASH intervention on cognitive function among adults with cardiovascular disease (CVD) risk and…
- Trial name
- ENLIGHTEN (NCT01573546)
- Testing
- Aerobic Exercise, DASH diet, Health education control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Duke University
Cognitive Dysfunction, Alzheimer Disease
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06733714
- Testing
- Transcranial Alternating Current Stimulation, Digital Cognitive Training
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro