Clinical trials: Cognitive Frailty
Frailty
Nutraceuticals and Drug Treatment in Frail Older Adults
Frailty is a multidimensional condition due to reserve loss leading to physical and cognitive impairment that is very common in older adults; in fact, its incidence increases with age.
- Trial name
- NCT04962841
- Testing
- Nutraceuticals
- Where
- Italy
- Volunteers
- 485 people
- Sponsor
- University of Campania Luigi Vanvitelli
Hospital Acquired Condition, Frailty
Effect of a Multicomponent Exercise Program With Virtual Reality (MEP-VR) vs Standard Approaches on Functional and Cognitive Domains in Hospitalized Geriatric Patients: Study Protocol for a Randomized Controlled Trial.
The goal of this clinical trial is to test the effectiveness of a Multicomponent Exercise Program with Virtual Reality (MEP-VR) compared to a Multicomponent Exercise Program (MEP-only) or usual care, in terms of functional and…
- Trial name
- MEP-VR (NCT06469554)
- Testing
- MEP-only group, MEP-VR group
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundacion Miguel Servet
Cognition, Sedation
Cognitive Function in Geriatric Colonoscopy Patients
Procedures such as colonoscopy cause discomfort and pain and are therefore performed under sedation and analgesia. Although patients aged 65 and older frequently undergo colonoscopy procedures, it is unclear to what extent the…
- Conditions
- Cognition, Sedation, Geriatric Anesthesia, Frailty
- Trial name
- NCT07384169
- Testing
- Propofol Group, Dexmedetomidine group
- Where
- Turkey (Türkiye)
- Volunteers
- 164 people
- Sponsor
- Ankara City Hospital Bilkent
Frailty at Older Adults, Mild Cognitive Impairment
A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity…
- Trial name
- TMS MRI TBS (NCT07497334)
- Testing
- Theta burst stimulation, Aerobic exercise
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- The Hong Kong Polytechnic University
Frailty, Cognitive Dysfunction
Trajectory of Frailty and Cognitive Dysfunction in Older Adults
To explore the heterogeneity of the development trend of frailty and cognitive function of older adults.
- Conditions
- Frailty, Cognitive Dysfunction, Community-dwelling Older Adults
- Trial name
- NCT06276166
- Testing
- No intervention
- Volunteers
- 934 people, healthy volunteers welcome
- Sponsor
- Zheng Li
Cardiovascular Diseases, Diabetes Mellitus
The Kunshan Elderly Health Study
The Kunshan Elderly Health Study (KEHS) is a community-based prospective cohort study of chronic disease, mortality and associated factors among elderly adults in Kunshan, Eastern China.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Cancer, Cognitive Impairment
- Trial name
- KEHS (NCT05141565)
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,945 people
- Sponsor
- Soochow University
Frailty, Sarcopenia
Comprehensive Geriatric Assessment in Adults Aged 40 Years and Older Living With HIV
People living with HIV are experiencing longer life expectancy due to effective antiretroviral therapy; however, they may develop age-related conditions earlier than the general population.
- Trial name
- HIV-AGE40 (NCT07453303)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Gastroesophageal Cancer (GC), Postoperative Delirium (POD)
Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer
The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery.
- Conditions
- Gastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty
- Trial name
- CASE (NCT06687291)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Karolinska Institutet
Physical Activity
Training Intervention in Heart Failure and Frail Elderly Population
There is enough scientific evidence of the benefits detection of frailty in patients with heart failure, which is an important prognostic factor.
- Trial name
- TIHFEP (NCT02365155)
- Testing
- Multicomponent training intervention., Nutrition intervention, Cognitive intervention
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital de la Ribera
Frailty at Older Adults
Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults
The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty.
- Trial name
- MRI exercise (NCT07513701)
- Testing
- Aerobic and resistance training, Usual Care
- Where
- Hong Kong
- Volunteers
- 224 people
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment (MCI)
Optimising Exercise to Improve Physical and Cognitive Frailty in Mild Cognitive Impairment
This investigational research aims to understand the mechanism of delaying the progression of dementia through different types of exercise.
- Trial name
- NCT07600034
- Testing
- Exercise training
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Universiti Sains Malaysia
Frail Elderly Syndrome
HOPE (Healthy Older People Everyday) To Age in Place
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented…
- Trial name
- NCT03797352
- Testing
- Multicomponent exercise
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Cognitive Frailty, Physical Function
VR Motor-cognitive Training for Older People With Cognitive Frailty
Cognitive frailty is a clinical syndrome in which cognitive impairment (e.g., poor memory, visuospatial function) and physical frailty (e.g., slowness, poor muscle strength, physical inactivity) co-exist.
- Trial name
- NCT04730817
- Testing
- Virtual Reality Motor-Cognitive Training System
- Where
- 6 sites in Hong Kong
- Volunteers
- 400 people
- Sponsor
- The Hong Kong Polytechnic University
Cognitive Impairment, Frailty
Smart Taiko-Drum Playing for Older Adults With Cognitive Frailty
The objective of this randomised controlled feasibility trial is to evaluate the feasibility of the Smart Taiko Drum-playing intervention embedding the cognitive-motor dual-task training concept for older adults with cognitive…
- Trial name
- NCT06115889
- Testing
- Smart Taiko Drumming
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Cognitive Frailty
Chair Exercise and Intergenerational Activities in Older Adults With Physio-Cognitive Decline Syndrome
The goal of this clinical trial is to investigate the effects of chair exercise followed by intergenerational activity in frailty syndrome and changes in serum mBDN levels among older adults with Physio-Cognitive Decline Syndrome…
- Trial name
- PCDS (NCT07335978)
- Testing
- Intervention 1
- Where
- Indonesia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Atma Jaya Catholic University of Indonesia
Frailty Syndrome
SHIP-AGE: Frailty, Renal Function, and Multi-component Primary Care in Rural Mecklenburg-Western Pomerania
Chronic kidney disease (CKD) is a leading risk factor for cardiovascular and all-cause mortality among the elderly. Mecklenburg-Western Pomerania has the largest prevalence of CKD in Germany and Europe.
- Trial name
- MV-FIT (NCT05962203)
- Testing
- Multi-factorial geriatric assessment, monitoring & management systems
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Frail Elderly Syndrome, Cognitive Impairment
Investigating My Active and Healthy Aging
This is a multicenter, multicultural, randomized control trial. Participants will be recruited from 10 centers located in Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea and Australia.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Physical Dependence
- Trial name
- my-AHA (NCT03342976)
- Testing
- My-AHA platform
- Where
- Italy
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
LONGEVITY 1, Frailty
Longevity in Russia
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.
- Conditions
- LONGEVITY 1, Frailty, Aging, Age-related Cognitive Decline
- Trial name
- NCT06268132
- Where
- Russia
- Volunteers
- 4,000 people
- Sponsor
- Center for Strategic Planning, of the Federal Medical and Biological Agency
Frail Elderly, Elderly
Fine-tuned Physical Training to Improve Quality of Life in Older Individuals
The overall aim of this project, which is based upon the interdisciplinary expertise of four research groups within the University of Rome Foro Italico, in the macro-areas of psychology, bioengineering, physiology, and internal…
- Conditions
- Frail Elderly, Elderly, Aging, Aging Frailty
- Trial name
- NCT07546734
- Testing
- Resistance Training (RT), Resistance training + CORE (RT+CORE), CMDT training
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Rome Foro Italico