Clinical trials: Cognitive Function, open to volunteers
Anesthesia Recovery Period ； Postoperative Pain； Hemodynamic Stability During Surgery
Afentanil and Remifentanil for Anesthesia Quality and Recovery
The goal of this clinical trial is to compare two commonly used opioid pain medications-alfentanil and remifentanil-during general anesthesia for surgery, and to find out whether alfentanil is as good as (not worse than)…
- Trial name
- NCT07761312
- Testing
- alfentanil, Remifentanil
- Volunteers
- 990 people
- Sponsor
- Qianfoshan Hospital
Psychotic Disorders, Cannabis Use Disorder
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Cannabis Dependence, Cannabis Use
- Trial name
- NCT05445180
- Testing
- Contingency management
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Chronic Low Back Pain, Spinal Cord Injury
SERENITY Study of Chronic Pain Interference in Adults
SERENITY is a remote observational study designed to characterize inter-individual differences in chronic pain among adults with chronic low back pain and adults with spinal cord injury-related neuropathic pain.
- Conditions
- Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain
- Trial name
- SERENITY (NCT07820475)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Cerebral Small Vessel Diseases, Dementia, Mixed
WHIte MAtter Hyperintensity Shape and Glymphatics
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases.
- Conditions
- Cerebral Small Vessel Diseases, Dementia, Mixed, Dementia, Vascular, Mild Cognitive Impairment
- Trial name
- WHIMAS (NCT06010511)
- Testing
- 3T MRI scan, 7T MRI scan, Neuropsychological assessment
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Cognitive Dysfunction, Stroke
Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project
The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling…
- Conditions
- Cognitive Dysfunction, Stroke, Dementia, Depression
- Trial name
- VESPAR (NCT05649800)
- Where
- 2 sites in United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Mild Cognitive Impairment (MCI)
Effects of Tadalafil on Cognition and Cerebral Hemodynamics in Elderly Patients With Mild Cognitive Impairment
The goal of this clinical trial is to determine if taking four weeks of a daily low dose of tadalafil is possible and safe in elderly males and females with mild cognitive impairment.
- Trial name
- NCT07882901
- Testing
- Tadalafil 5 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Los Angeles Brain Science Project
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Edentulism, Biological Aging
Biological Aging Following Full-Arch Implant-Supported Fixed Rehabilitation in Edentulous Patients
This study aims to investigate the association between full-arch implant-supported fixed dental rehabilitation and changes in biological aging among adults with complete tooth loss (edentulism).
- Trial name
- NCT07890753
- Testing
- Full-Arch Implant-Supported Fixed Dental Rehabilitation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Junyu Shi
Early-Stage Breast Cancer, Neoadjuvant Therapy
COGNITION: Genomics-Guided Precision Oncology in Early High-Risk Breast Cancer
The COGNITION diagnostic platform elucidates the biomarker profile of neoadjuvant chemotherapy-resistant residual bulk tumors in high risk early breast cancer patients.
- Trial name
- COGNITION (NCT05906407)
- Testing
- Genomic Profiling / Sequencing
- Where
- 12 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German Cancer Research Center
PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)
Dual-task Cognitive-motor Telerehabilitation in Persons With PD-MCI
Telerehabilitation is a promising tool for treating and preventing further disease progression in Parkinson's disease (PD) [1, 2].
- Trial name
- HomeFitPD (NCT07411365)
- Testing
- Dual-task Cognitive Motor Training, Cognitive Motor Training
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University Hospital Tuebingen
Sickle Cell Disease, Executive Dysfunction
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork…
- Conditions
- Sickle Cell Disease, Executive Dysfunction, Cognitive Impairment, Attention Deficit/Hyperactivity Disorder (ADHD)
- Trial name
- NCT07226219
- Testing
- Extended-Release Methylphenidate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- St. Jude Children's Research Hospital
Geriatric Population, Cognitive Ability
The Cognitive-Functional Relationship in Geriatric Hand-Forearm Injuries
Considering the complex structure of hand-forearm injuries and the long rehabilitation process, it is important to investigate factors associated with recovery in geriatric individuals.
- Conditions
- Geriatric Population, Cognitive Ability, Functional Abilities, Hand Injuries
- Trial name
- NCT07379229
- Testing
- Questionnaire and Physical Exam
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Pamukkale University
Strength Training Adaptations, Stress
The Impact of 12-week Ashwagandha Supplementation Induced by Resistance Training on Strength, Levels of Neurotrophic and Stress Response Proteins, Oxidative and Psychological Stress, and Cognitive Function in Physically Active Male Adults
This clinical trial will study the effects of Ashwagandha (Withania somnifera), a natural plant extract, on physical and mental health in adult men.
- Conditions
- Strength Training Adaptations, Stress, Sleep Quality, Cognitive Functions
- Trial name
- NCT07803068
- Testing
- Ashwagandha, Resistance training
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Cognition, BDNF
Investigating the Evolutionary Impact of Metabolic Flexibility on Physical Activity-Dependent BDNF and Cognition: Insights From the Val66Met Polymorphism
The goal of this clinical trial is to learn if a state of ketosis and physical activity will increase serum BDNF concentrations and improve cognition, specifically in individuals who possess the Met allele from the BDNF Val66Met…
- Trial name
- NCT07218497
- Testing
- d-beta-hydroxybutrate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Mild Cognitive Impairment, Aging
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
The investigators aim to use the new PET radioligand, 18F-MK-6240, to detect tau pathology in cognitive healthy and mild cognitive impairment (MCI) elders.
- Trial name
- NCT03372317
- Testing
- 18F-MK-6240
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yaakov Stern
Sensory Impairments, Cognitive Impairment
Development of an Ensemble Learning-based, Multi-dimensional Sensory Impairment Score to Predict Cognitive Impairment in an Elderly Cohort of Southern Italy
There is now strong scientific literature showing a relationship between sensory loss and cognitive performance and between sensory loss and incident dementia.
- Conditions
- Sensory Impairments, Cognitive Impairment, Artificial Intelligence
- Trial name
- DEMETRA (NCT06783010)
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria Locale Bari
THC
THC Titration of High-Potency Cannabis Concentrates
High-potency cannabis use is associated with public health risks, such as cannabis use disorder, psychotic disorders, and impaired cognition.
- Trial name
- THC Titration (NCT07105449)
- Testing
- Cannabis (30% THC Concentrate), Cannabis (60% THC Concentrate), Cannabis (90% THC Concentrate)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Dementia With Lewy Bodies
Ambroxol in New and Early DLB, A Phase IIa Multicentre Randomized Controlled Double Blind Clinical Trial
This is a confirmatory investigational medicinal product (IMP) study to investigate the effects on cognition, functional decline and on neuropsychiatric symptoms of the Glucocerebrosidase (GCase) enhancing chaperone ambroxol in…
- Trial name
- ANeED (NCT04588285)
- Testing
- Ambroxol
- Where
- 8 sites in Norway
- Volunteers
- 180 people
- Sponsor
- Helse Fonna
ADHD
Evaluating a Digital Cognitive Training Intervention in Adults With ADHD
The goal of this clinical trial is to evaluate whether a digital cognitive training program can reduce symptoms of ADHD, improve executive functioning, and decrease problematic internet use in adults aged 18-65 with a diagnosis…
- Trial name
- NCT07050225
- Testing
- Digital Cognitive Training, Digital Non-cognitive Training Intervention
- Volunteers
- 52 people
- Sponsor
- McMaster University
Duchenne Muscular Dystrophy, Duchenne Disease
Evaluating VM100 Nutritional Supplement for Improving Quality of Life in Duchenne Muscular Dystrophy Patients
This pilot study will investigate the potential efficacy of VM100, a nutritional supplement specifically formulated for patients with DMD, on quality of life and physical symptoms.
- Conditions
- Duchenne Muscular Dystrophy, Duchenne Disease, Muscular Dystrophy in Children, DMD
- Trial name
- NCT07766980
- Testing
- VM100 Nutritional Supplement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
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