Clinical trials: Cognitive Function Assessment, open to volunteers
Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI)
A Study of QLH2405 in Healthy Participants and Participants With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of QLH2405 injection in healthy participants and participants with mild cognitive impairment (MCI) due to…
- Trial name
- NCT07489599
- Testing
- QLH2405
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Huntington Disease, HD
iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009
This is a FIH (first-in-human) study to evaluate the clinical utility of the radioligand [11C]CHDI-00491009 as a PET tracer that binds specifically to mutant huntingtin (mHTT) aggregates in Huntington's disease (HD).
- Conditions
- Huntington Disease, HD, PET Tracer, Positron Emission Tomography
- Trial name
- iMagemHTT-009 (NCT06634628)
- Testing
- Radioligand [11C]CHDI-00491009
- Where
- Belgium
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- CHDI Foundation, Inc.
Healthy Participants
Testing Healthy Participants for Drowsiness After Single Dosing of Two Different Doses of Muscle Relaxer
Health participants take a single dose, perform testing, washout for one week, take a single dose of different formulation, and perform testing for comparison of the 2 doses.
- Trial name
- NCT07801066
- Testing
- Metaxalone 640 mg, Metaxalone 800 MG
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Primus Pharmaceuticals
Lacunar Stroke
A Multicenter Randomized Clinical Trial Compared With Standard Clinical Practice to Evaluate the Efficacy of a Polyphenol-rich Salicornia Extract in the Progression of Cognitive Decline in a Cohort of Patients With Lacunar Infarcts (SALACUNAR)
SALACUNAR (LACI-2-polyphenols) is a multi-center randomized controlled trial (RCT) to evaluate the effect of a polyphenol-rich supplement on small vessel neurovascular disease.
- Trial name
- SALACUNAR (NCT07353424)
- Testing
- B-salicornia
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Learning, Cognitive Functioning
Dual Orexin Antagonism and Emotion and Affective Processing Study
In this study, the investigators will examine the effects of blocking the orexin system on human behaviour and brain function using daridorexant, a medication that inhibits orexin activity.
- Conditions
- Learning, Cognitive Functioning, Emotional Processing
- Trial name
- DOREA (NCT07267559)
- Testing
- Daridorexant 50 mg
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cognition Disorders in Old Age, Cognitive Decline
Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults.
The current project is dedicated to creating a comprehensive cognitive and neural assessment platform and corresponding norms tailored specifically to the older adults in Macau.
- Conditions
- Cognition Disorders in Old Age, Cognitive Decline, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT06239922
- Where
- Macau
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Macau
Frailty, Aging
Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition
This randomized clinical trial investigates the effects of a home-based multicomponent exercise program (Vivifrail) on physical function, muscle morphology, and cognition in community-dwelling adults aged 90 years and older.
- Conditions
- Frailty, Aging, Cognitive Decline
- Trial name
- Vivifrail (NCT07731529)
- Testing
- Vivifrail multicomponent exercise program
- Where
- 2 sites in Brazil
- Volunteers
- 54 people
- Sponsor
- Federal University of Rio Grande do Sul
Cardiac Arrest (CA)
Effects of a Web-based Support Programme for Cardiac Arrest Survivors
The overall goal of this clinical trial is to learn if a web-based support programme can improve wellbeing in cardiac arrest survivors by helping them manage emotional, cognitive, and physical challenges.
- Trial name
- CARDIS (NCT07240714)
- Testing
- Digital Support Programme
- Where
- 9 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Linkoeping University
Mild Cognitive Impairment (MCI)
Assessment of Motor Reserve in the Preclinical Stages of Dementia
Mild Cognitive Impairment (MCI) is a clinical condition associated with an increased risk of progression to dementia. Although cognitive alterations have traditionally been the main focus of investigation, growing evidence…
- Trial name
- NCT07634055
- Testing
- Sensor-based medical device for kinematic assessment: Hand Test System (HTS)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Pregnancy, Postpartum
HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children
Regular exercise during pregnancy and postpartum leads to health benefits for mother and child. Inactivity during pregnancy and after delivery is now treated as risky behavior.
- Conditions
- Pregnancy, Postpartum, Childbirth, Health Status
- Trial name
- HIIT MAMA (NCT05009433)
- Testing
- High intensity interval training program for pregnant women, Moderate intensity continuous training program for pregnant women, Standard obstetric care with extended education on healthy lifestyle
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Cancer, Sarcopenia
JUMP Prevalence of Sarcopenia and Chemobrain in Post-cancer Patients
Therapeutic advances in oncology have transformed the prognosis of cancer patients, placing a significant number of them either in a context of recovery or in prolonged remission close to a chronic disease.
- Trial name
- JUMP (NCT05800535)
- Testing
- Study of the adverse effects of long-term oncological treatments, Study of the long-term side effects of oncological treatments on the anxiety-depressive and cognitive state of patients
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Huntington Disease
Longitudinal Endpoint Assessment of Disease Burden in HD
LEAD-HD is intended to collect and analyze self-reported health information from individuals with Huntington Disease (HD) or prodromal HD participating in a 24-month longitudinal natural history study using remote technologies.
- Trial name
- LEAD-HD (NCT06475898)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Huntington Study Group
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Chinese University-Alzheimer's Disease With Vascular and Other Co-pathology: Towards Actionable Neuro-Cognitive-Omic Evaluations (CU-ADVANCE)
Population aging is transforming the epidemiological landscape of the Asia-Pacific region at an unprecedented pace. By 2050, more than one quarter of the region's population will be aged over 60, with 36.7% of countries projected…
- Trial name
- NCT07917182
- Where
- China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Post Intensive Care Syndrome (PICS), Cognitive Impairment
Eye Tracking for Early Identification of Post-ICU Cognitive Impairment
Some patients may have problems with memory, attention, thinking speed, or other cognitive functions after leaving the intensive care unit (ICU). This is called post-ICU cognitive impairment.
- Trial name
- NCT07676864
- Where
- China
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Vestibular Dysfunction, Dizziness
Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks
This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same…
- Conditions
- Vestibular Dysfunction, Dizziness, Falls (Accidents) in Old Age, Balance Assessment
- Trial name
- NCT07735078
- Testing
- Instrumented balance and gait assessment using wearable inertial sensors, Questionnaires and paper-based cognitive tests
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Aerobic Exercise, Cognitive Change
The Role of the Time of Day in the Effects of Exercise on Memory in Heathy Young Adults
Cumulative evidence indicates that a single bout of exercise has beneficial impacts on memory in young adults. From a physiological perspective, acute exercise leads to changes of heart rate variability (HRV), which is associated…
- Trial name
- TEEMY (NCT04861818)
- Testing
- Moderate-intensity aerobic exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Cognitive Assessment, Cognition
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Cognitive Performance and Sex Differences
This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cognitive performance in healthy adults.
- Conditions
- Cognitive Assessment, Cognition, taVNS, Vagus Nerve Stimulation
- Trial name
- NCT07256080
- Testing
- Active taVNS
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Acute Stroke, Ischemic Stroke
Impact of Stroke Unit Care on Acute Stroke Outcomes
This observational study is designed to evaluate and compare the recovery outcomes of patients who have experienced their first acute stroke.
- Conditions
- Acute Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT07750860
- Volunteers
- 140 people
- Sponsor
- Assiut University
Traumatic Brain Injury
TBI Rehabilitation and Activation in Veterans
This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain…
- Trial name
- TRAIN-Vets (NCT06562127)
- Testing
- TRAIN-Vets, Health Education Control
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Northern California Institute of Research and Education
Disorder of Consciousness
Evaluation of the MuSICCA for Measuring Awareness
Prolonged Disorders Of Consciousness (PDOC) include the Vegetative State (VS) and the Minimally Conscious State (MCS) that persist for longer than four weeks.
- Trial name
- NCT04050995
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 80 people
- Sponsor
- The Children's Trust, United Kingdom