Clinical trials: Cognitive Function Decline
Cognitive Decline, Cancer
Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Cancer survival rates have increased dramatically in recent years. However, many survivors report cognitive decline following treatment, which significantly impairs their quality of life.
- Trial name
- CRCI (NCT04210778)
- Testing
- Cognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Cognitive Decline, Executive Dysfunction
Fitness on White Matter and Cognition in Aging
Cardiorespiratory fitness (CRF) is associated with decreased risk for mild cognitive impairment (MCI) and dementia. CRF is linked with more conserved gray and white matter (WM) volume, improved WM microstructural integrity, and…
- Conditions
- Cognitive Decline, Executive Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03775941
- Volunteers
- 645 people, healthy volunteers welcome
- Sponsor
- Suffolk University
Subjective Cognitive Decline (SCD)
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.
- Trial name
- SmartAge (NCT03094546)
- Testing
- Polyamine
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Alzheimer Disease, Mild Cognitive Impairment
Longitudinal Study for the Characterization of the Phases of Subjective Perception of Cognitive Decline and Mild Cognitive Impairment of Alzheimer's Disease.
Alzheimer's disease (AD) is the leading cause of dementia and its prevalence is estimated to exceed 100 million affects by 2050, becoming the main public health problem worldwide.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT03851523
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Stroke, TBI
Characterization of the DELPhI System in Assessing Brain's Functionality in Different Neurological Disorders
We use Transcranial magnetic stimulation (TMS), combined with simultaneous registration of electroencephalograph (EEG),for examining human cortical functionality.
- Conditions
- Stroke, TBI, Fibromyalgia, PDD
- Trial name
- NCT03832413
- Testing
- DELPhI (TMS-EEG analysis)
- Where
- Israel
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Cognitive Decline
Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline
The aim of this study is to investigate the modulation effects of Baduanjin (BDJ), a simple and innovative mind-body exercise, on cognitive function, resting state functional connectivity, and brain morphometry in individuals…
- Trial name
- BDJ (NCT04009382)
- Testing
- Baduanjin Exercise, Cognitive Fitness Program
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Vestibular Dysfunction, Dizziness
Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks
This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same…
- Conditions
- Vestibular Dysfunction, Dizziness, Falls (Accidents) in Old Age, Balance Assessment
- Trial name
- NCT07735078
- Testing
- Instrumented balance and gait assessment using wearable inertial sensors, Questionnaires and paper-based cognitive tests
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Aging
Improvement in Memory With Plasticity-Based Adaptive Cognitive Training (IMPACT)
The primary objective of this study is to evaluate the effects of a computer-based training program on the memory and cognitive abilities of mature individuals undergoing healthy aging.
- Trial name
- IMPACT (NCT00283010)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Educational DVDs
- Where
- United States
- Volunteers
- 487 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Frail Elderly Syndrome
HOPE (Healthy Older People Everyday) To Age in Place
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented…
- Trial name
- NCT03797352
- Testing
- Multicomponent exercise
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Caregiver Burden, Depression
Support for Caregivers of Older Adults With Cognitive Decline
This randomized control study is to test effectiveness of occupational therapy support for informal caregivers of older adults with cognitive decline.
- Conditions
- Caregiver Burden, Depression, Confidence, Self, Cognition
- Trial name
- NCT04787068
- Testing
- Occupational Therapy support
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Risk Behavior, Cognitive Decline
Multidomain Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention
The overarching aim is to develop and deploy a multidomain intervention delivered on a mobile application to help middle-aged to older adults reduce their risk for dementia by improving a set of modifiable lifestyle risk factors…
- Trial name
- NCT05141578
- Testing
- Luci Coach Assisted Intervention
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- LuciLab
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Subjective Cognitive Decline
tDCS-enhanced Working Memory Training in Subjective Cognitive Decline
This 2-armed randomized, sham-controlled, single-blind study aims at providing evidence for the efficacy of a transcranial direct current stimulation (tDCS)-enhanced cognitive control training (PASAT) in participants with…
- Trial name
- NCT03236454
- Testing
- DC-Stimulator MC, NeuroConn
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Alzheimer Disease, Cognitive Impairment
Biomarker Exploration in Aging, Cognition and Neurodegeneration
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- BEACoN (NCT03860857)
- Testing
- Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Menopause, Cognitive Change
PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition
This is a proof-of-concept phase 2 clinical trial to investigate the safety and effect of the phytoestrogenic supplement PhytoSERM on regional brain metabolism by fluorine-18 fluorodeoxyglucose positron emission tomography…
- Conditions
- Menopause, Cognitive Change, Brain Disorder, Metabolic
- Trial name
- NCT05664477
- Testing
- PhytoSERM
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Roberta Brinton
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Healthy, Subjective Cognitive Decline (SCD)
Sleep Stimulation to Enhance Waste Clearance in the Brain
This study aims to examine whether multi-night closed-loop auditory stimulation (CLAS) during sleep can enhance waste clearance and memory consolidation in healthy adults and older adults with subjective cognitive decline or mild…
- Conditions
- Healthy, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
- Trial name
- NCT07051239
- Testing
- Closed-loop acoustic stimulation
- Where
- Belgium
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Type 2 Diabetes, Subjective Cognitive Decline
China Diabetes Cognitive Dysfunction Early Diagnosis and Intervention Study (China-DECODE Study)
Type 2 diabetes (T2D) and dementia are both diseases with increasing incidence and prevalence globally, leading to substantial economic burdens for families and society.
- Conditions
- Type 2 Diabetes, Subjective Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06650969
- Testing
- Naturalistic observation
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cancer, Breast, Age-related Cognitive Decline
Older Breast Cancer Patients: Risk for Cognitive Decline
The goal of this study is to evaluate the impact of systemic therapy on cognition in older breast cancer patients, explore change in APE, LM and Cognition domains, measure associations between cognitive decline and QOL, and…
- Conditions
- Cancer, Breast, Age-related Cognitive Decline, Cognitive Decline
- Trial name
- TLC (NCT03451383)
- Where
- United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Georgetown University