Clinical trials: Cognitive Function Decline
Subjective Cognitive Decline
Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline
The team "Cognitive intervention, cognitive reserve and brain plasticity", Team 10, is part of the Canadian Consortium on Neurodegeneration in Aging (CCNA).
- Trial name
- NCT03271190
- Testing
- ENGAGE SPANISH/MUSIC, ENGAGE DISCOVERY
- Where
- 2 sites in Canada
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cognitive Decline
Physical and Cognitive Training System for Neurocognitive Protection and Enhancement in Older Adults
Neurocognitive decline is a health issue that is associated with ageing. It is often irreversible from the onset. The concomitant costs of neurocognitive decline could be potentially exponential if left unchecked.
- Trial name
- NCT05163769
- Testing
- NeeuroCycle Physical and Cognitive Training System, NeeuroCycle Cognitive Training System
- Where
- Singapore
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Cognitive Decline, Cardiovascular Diseases
Lifestyle Physical Activity and Cognitive Training Interventions
Older women with cardiovascular disease (CVD) are at greater risk for memory loss, an important public health issue due to the negative effects to quality of life and health care costs.
- Conditions
- Cognitive Decline, Cardiovascular Diseases, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- MindMoves (NCT04556305)
- Testing
- Mind, Move
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Aging, Cognitive Decline
Yoga, Aerobic and Stretching Exercise Effects on Neurocognition
The investigators propose to conduct a 6-month 3-arm randomized controlled exercise trial among older adults to compare the efficacy of yoga with aerobic exercise and stretching-toning exercises on cognitive function, brain…
- Trial name
- NCT04323163
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Cognitive Decline
Adult Broad Learning Experiment (ABLE): Feasibility Study
This study evaluates the feasibility of enrolling and retaining older adults in a 15-week intervention that will implement six factors from early childhood experiences: individualized scaffolding (having a responsive teacher)…
- Trial name
- ABLE (NCT03438136)
- Testing
- Adult Broad Learning Experiment (ABLE)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, Riverside
Alzheimer Disease, Dementia
Movement Intervention for Memory Enhancement
Dancing is a complex sensorimotor rhythmic activity that integrates cognitive, physical, and social components and is applicable to seniors with various fitness levels.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Decline, Cognitive Impairment
- Trial name
- MIME (NCT03475316)
- Testing
- Social Dancing, Treadmill Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Sedentary Time, Insomnia
mPATH for Low-income Older Adults
Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults.
- Conditions
- Sedentary Time, Insomnia, Cognitive Decline
- Trial name
- NCT05935241
- Testing
- mPATH, Attention Control
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Mild Cognitive Impairment
Cognitive Screening Made Easy for PCPs
In the United States and around the world, people are living longer lives. As the population ages, so does the number of older adults who may experience declines in memory, attention, reasoning, or other thinking skills.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT05082883
- Testing
- Risk Assessment Cognitive Screening
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Healthy
Effects of Vitamin D3 Supplementation on Cognitive Function in Community Dwelling Older Adults
Ireland is predicted to have the highest older adult population growth of any European Union country. A substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the…
- Trial name
- NCT02804841
- Testing
- Cholecalciferol -Vitamin D3
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Caregiver Burden, Depression
Support for Caregivers of Older Adults With Cognitive Decline
This randomized control study is to test effectiveness of occupational therapy support for informal caregivers of older adults with cognitive decline.
- Conditions
- Caregiver Burden, Depression, Confidence, Self, Cognition
- Trial name
- NCT04787068
- Testing
- Occupational Therapy support
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Mild Cognitive Impairment
Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.
- Trial name
- NCT04070703
- Testing
- The Go for Exercise & Healthy Aging Project
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Mild Cognitive Impairment, Alzheimer's Disease
Arterial Spin Labeling (ASL) MRI for Cognitive Decline
The purpose of this study is to determine the value of Arterial Spin Labeling (ASL) MRI, a measure of blood flow to the brain, in Mild Cognitive Impairment (MCI) and compare it to existing measures.
- Trial name
- NCT01727622
- Testing
- FDG-PET, ASL-MRI, Lumbar Puncture
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nasopharyngeal Carcinoma (NPC)
Brain Alterations Based on Multiplex MR Imaging in Nasopharyngeal Carcinoma Patients After Treatment, and Their Correlation With Clinical Cognitive Scores.
The objective of this study is to examine the potential impact of the treatment before, during, and/or after radiotherapy on the brain in patients with nasopharyngeal carcinoma (NPC) using Multiplex (MTP) MR imaging sequence…
- Trial name
- NPC (NCT07011329)
- Testing
- Changes in the brain MTP parameters after radiotherapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hubei Cancer Hospital
Cognitive Decline
A Home-based e-Health Intervention in the Elderly: MOVI-ageing
This protocol study aims to evaluate the efficacy of the MOVI-ageing intervention, a complex home-based eHealth intervention of cognitive-demanding exercise for the elderly, in improving: global cognitive function and basic…
- Trial name
- MOVI-ageing (NCT05928078)
- Testing
- intervention
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Vestibular Dysfunction, Dizziness
Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks
This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same…
- Conditions
- Vestibular Dysfunction, Dizziness, Falls (Accidents) in Old Age, Balance Assessment
- Trial name
- NCT07735078
- Testing
- Instrumented balance and gait assessment using wearable inertial sensors, Questionnaires and paper-based cognitive tests
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Metabolic Disorders and Cognitive Decline
Effects of Whole Grain Rye on Metabolic Risk Markers and Mood
The purpose of the study is to investigate, in healthy middle age subjects, effects of whole grain rye on cognitive functions, mood, and cardiovasculair risk markers
- Trial name
- NCT03275948
- Testing
- whole grain, reference
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lund University
Muscle Weakness, Bone Health
Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment and falls in older adults carry an increased risk for poor health outcomes and if identified early, can be…
- Conditions
- Muscle Weakness, Bone Health, Cognitive Decline
- Trial name
- HOPE-DIET (NCT03786835)
- Testing
- Protein supplementation and regular physical activity
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Cognitive Impairment
Early Detection of Cognitive Decline
The goal of this clinical trial is to evaluate the impact of a brief cognitive screener on provider behavior in patients completing an annual wellness visit (AWV).
- Trial name
- EDCD (NCT05804981)
- Testing
- PRO-CS
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- RAND