Clinical trials: Cognitive Function Decline
Cognitive and Behavioral Impairment
Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment
This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD).
- Trial name
- NCT07135336
- Testing
- surgery, norma
- Where
- China
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Peking University Shenzhen Hospital
Gait Apraxia, Mild Cognitive Impairment
Gait as Predictor of Dementia and Falls. The Gait and Brain Cohort Study
Motor slowing and cognitive slowing are more prevalent as we age. Importantly, the presence of both in an older person increases their risk of having dementia by ten times.
- Conditions
- Gait Apraxia, Mild Cognitive Impairment, Subjective Cognitive Impairment, Cerebral Atrophy
- Trial name
- NCT03020381
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Manuel Montero Odasso
Artificial Intelligence Technology, Cognitive Decline
Preliminary Research Using Artificial Intelligence Technology to Identify Differences in Facial Expressions Between Healthy People, Patients With Cognitive Decline, and Patients With Dementia
Through artificial intelligence technology, we have conducted a preliminary study aimed at identifying differences in facial expressions among healthy individuals, patients with cognitive decline, and dementia patients.
- Conditions
- Artificial Intelligence Technology, Cognitive Decline, Dementia, Identify
- Trial name
- NCT06513403
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD)
Italian Adaptation and Validation of Functional and Behavioural Scales for Subjective Cognitive Decline, Mild Cognitive Impairment and Mild Dementia.
The first aim of the observational study is the translation, cross-cultural adaptation and validation of functional and behavioral scales used in the diagnosis of neurodegenerative diseases, for which a formal version in Italian…
- Conditions
- Neurologically Unimpaired Elderly Participants, Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), Major Neurocognitive Disorder
- Trial name
- ITA-VALI-DEM (NCT06701630)
- Where
- Italy
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Casa di Cura IGEA
Mild Cognitive Disorder
Study on the Effect of Online Cognitive Training Doses on Cognitive Function in Individuals With Mild Cognitive Decline
The primary questions that this clinical trial aims to answer are: To compare the differences in the efficacy of different doses of Computerized Cognitive Training (CCT) in improving cognitive function among patients with Mild…
- Trial name
- NCT07213362
- Testing
- Computerized Cognitive Training
- Volunteers
- 234 people
- Sponsor
- Peking University
Cognitive Dysfunction, Cognition Disorder
Nutrition-based Interventions to Prevent Cognitive Decline
This study intends to evaluate the feasibility and the effectiveness of an innovative and integrated nutrition-based intervention addressing key modifiable risk factors for dementia while meeting participants' preferences for…
- Conditions
- Cognitive Dysfunction, Cognition Disorder, Memory Disorders, Cognitive Impairment
- Trial name
- NUTRIMIND (NCT06853405)
- Testing
- Nutrition-related lifestyle group sessions, Cognitive training, Clinical nutrition consultations
- Where
- 2 sites in Portugal
- Volunteers
- 120 people
- Sponsor
- Instituto de Saude Publica da Universidade do Porto
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Lifestyle, Cognitive Decline
Brain-Health Lifestyle Restructuring Intervention
With population aging, the number of older persons with cognitive impairments increases. Literature support the effectiveness of a lifestyle approach to promote the health of persons with cognitive impairment, as well as a…
- Conditions
- Lifestyle, Cognitive Decline, Aging
- Trial name
- NCT04576624
- Testing
- Lifestyle Intervention, social activity
- Where
- Taiwan
- Volunteers
- 125 people
- Sponsor
- National Cheng Kung University
Alzheimer Disease (AD), Mild Cognitive Impairment (MCI)
China HEalthy Aging and Dementia Study (HEAD)
The China HEalthy Aging and Dementia (HEAD) study is a large-scale, community-based, multi-center prospective cohort study covering eastern, northern, southern, and central-western regions of China.
- Conditions
- Alzheimer Disease (AD), Mild Cognitive Impairment (MCI), Dementia, Vascular Dementia (VaD)
- Trial name
- NCT07912710
- Where
- 30 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Aging, Mortality
Human Observatory Study
The Human Observatory Study is a prospective observational and ecological surveillance study building a continuously-updating world model for human health, disease, and death at the individual and population level.
- Conditions
- Aging, Mortality, All-cause Mortality, Life Expectancy
- Trial name
- HOS (NCT07646782)
- Testing
- Multi-Domain Ecological and Clinical Data Linkage
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Cerebral Vascular Accident (CVA)/Stroke
Transcranial Doppler (TCD) Ultrasound and Cognition in Cerebral Vascular Disease. (SUNRISE)
This study aims to contribute to the identification of factors that may be predictive of cognitive function and to provide data on cerebral hemodynamic in ischemic and haemorrhagic stroke.
- Trial name
- SUNRISE (NCT06735274)
- Testing
- Cerebral Autoregulation (CAR), Neurovascular coupling (NVC), Microembolic signals (MES)
- Where
- Portugal
- Volunteers
- 517 people
- Sponsor
- Universidade do Porto
Age-related Cognitive Decline, Mild Cognitive Impairment
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown.
- Conditions
- Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
- Trial name
- NCT04171323
- Testing
- Cognitive Training, Computerized Cognitive Stimulation
- Where
- 6 sites in United States
- Volunteers
- 1,305 people
- Sponsor
- University of Alabama at Birmingham
Risk Behavior, Cognitive Decline
Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention
Alzheimer's Disease (AD) and other Dementias have far-reaching consequences on the lives of sufferers and their loved ones, not to mention the impact on the healthcare system.
- Trial name
- NCT06748625
- Testing
- Luci Coach-Assisted Intervention
- Where
- Canada
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- LuciLab
Cognitive Decline
TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics.
The study is based on the hypothesis that the integration of biological, psychological, and social factors, according to the biopsychosocial paradigm, allows for more accurate identification of the different stages of the…
- Trial name
- TRIAD (NCT07399418)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Progressive Cognitive Decline
Potential of Florbetapir F 18 PET to Inform Clinical Diagnosis and Management of Patients With Progressive Cognitive Decline
The study is designed to evaluate whether a florbetapir F 18 PET scan can impact clinical thinking when physicians are determining the likely cause of a subject's cognitive impairment.
- Trial name
- NCT01400425
- Testing
- florbetapir F 18
- Where
- 18 sites in United States
- Volunteers
- 239 people
- Sponsor
- Avid Radiopharmaceuticals
Multiple Sclerosis, Cognitive Decline
Computerized Cognitive Training in MS
WHO: 40 participants with a confirmed diagnosis of Multiple Sclerosis (MS) able to engage in moderate physical activity. WHY: The purpose of this study is to evaluate two computerized brain training tools, which include light…
- Trial name
- NCT03737825
- Testing
- Computerized gaming rehabilitation Program 1, Computerized gaming rehabilitation Program 2
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Frail Elderly Syndrome, Cognitive Impairment
Investigating My Active and Healthy Aging
This is a multicenter, multicultural, randomized control trial. Participants will be recruited from 10 centers located in Italy, Germany, Austria, Spain, United Kingdom, Belgium, Sweden, Japan, South Korea and Australia.
- Conditions
- Frail Elderly Syndrome, Cognitive Impairment, Physical Dependence
- Trial name
- my-AHA (NCT03342976)
- Testing
- My-AHA platform
- Where
- Italy
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Healthy Ageing, Cognitive Decline
Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilities in Healthy Ageing.
This project investigates the relative benefits of regular physical activity and bilingualism for ameliorating cognitive decline in healthy ageing, with a particular focus on language function.
- Conditions
- Healthy Ageing, Cognitive Decline, Cardiorespiratory Fitness
- Trial name
- FAB (NCT07443189)
- Testing
- Home-Based HIIT
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- University of Agder
Cognitive Decline, Cognitive Impairment, Mild
Effects of Multimodal Training of Combined Cognitive and/or Physical Training on Cognition and Fitness of Older Adults
The elderly population worldwide is expected to increase exponentially. There will be a higher percentage of older adults suffering cognitive decline in the coming decades.
- Trial name
- MTCCP (NCT04727450)
- Testing
- Cognitive training, physical training, Combination of cognitive and physical training (CCPT)-BIGMAP
- Where
- Hong Kong
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Obesity
Vibegron for ENergy Thinking and Resilience in Aging
This 12-week randomized, double-blind, placebo-controlled trial will test the hypothesis that Vibegron (brand name GEMTESA) can improve energy metabolism, cardiometabolic risk factors, and physical and cognitive function in…
- Trial name
- VENTURA (NCT06987383)
- Testing
- Vibegron
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences