Clinical trials: Cognitive Function Decline
Cognition
Cognition in Postoperative Total Hip Arthroplasty and Total Hip Resurfacing Patients
Transient cognitive changes after surgery may be due to many different factors. It is estimated that between 5-29% of patients undergoing orthopedic surgery experience a transient decline in their cognition.
- Trial name
- NCT01079468
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Subjective Cognitive Decline (SCD)
Polyamine-enriched Diet in Elderly Individuals With Subjective Cognitive Decline
The overall objective of this study is to examine the effect of polyamine supplementation on cognitive performance and further characterization of individuals with subjective cognitive decline.
- Trial name
- SmartAge (NCT03094546)
- Testing
- Polyamine
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Coronary Artery Bypass, Delirium
Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane
Background: Different anaesthetic agents have been shown to have different protective effects upon heart, brain and renal function under ischaemic conditions (oxygen starvation).
- Conditions
- Coronary Artery Bypass, Delirium, Dementia, Amnesia
- Trial name
- NCT00400790
- Testing
- propofol, desflurane
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- University of Melbourne
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment
The goal of this clinical trial is to determine whether a home-based digital cognitive-training program called RICORDO can enhance patients' ability to manage their own health and daily life when they have Mild Cognitive…
- Trial name
- COG-FIT (NCT07286448)
- Testing
- RICORDO, S.A.M.B.A.
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Giovanna Zamboni
Cognitive Decline, Cognitive Change
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia.
- Conditions
- Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium
- Trial name
- NCT03839784
- Testing
- Neurocognition Interventions
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Stanford University
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing)…
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT05373745
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Massachusetts General Hospital
Post-Operative Confusion
Braindex Cerebral Tissue Oxygen Saturation (SctO2) Measurement Algorithm Assessment and Improvement
The objective of this clinical trial is to optimize Braindex brain tissue oxygen saturation (SctO2) measurement algorithm compared to a mixed reference value of jugular venous and systemic arterial saturation, during proven…
- Trial name
- POC-SctO2 (NCT05897060)
- Testing
- Venus Jugular O2 Saturation optical fiber
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Braindex
Age Related Cognitive Decline, Alzheimer's Disease
n-3 PUFA for Vascular Cognitive Aging
Brain scans can help identify changes that appear to increase risk for cognitive decline and dementia. Some of these brain changes are thought to reflect actual damage to the small blood vessels that support normal brain…
- Conditions
- Age Related Cognitive Decline, Alzheimer's Disease, Vascular Dementia, Endothelial Dysfunction
- Trial name
- NCT01953705
- Testing
- Omega 3 PUFA
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cognitive Decline
Cognitive Function in Elderly Marathon Runners
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly.
- Trial name
- APSOEM (NCT01045031)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cognitive Decline
Evaluation of Cognitive State in Seniors Using Neurosteer EEG System
This is an observational study. Patients who fulfill all inclusion criteria and none of the exclusion criteria will be enrolled in the study, be neurologically evaluated and will go through EEG recordings while listening to an…
- Trial name
- NCT05528445
- Testing
- Neurosteer EEG recorder
- Where
- Israel
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Neurosteer Ltd.
Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage
REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study
The investigators propose to perform serial detailed cognitive, motor, behavioral, and blood collection follow-up using longitudinal structured telephone interviews of an anticipated 350 ICH survivors enrolled in Minimally…
- Conditions
- Intra Cerebral Hemorrhage, ICH - Intracerebral Hemorrhage, ICH, Hemorrhage
- Trial name
- ICH03 (NCT05611918)
- Where
- 26 sites in United States
- Volunteers
- 350 people
- Sponsor
- Johns Hopkins University
Alzheimer's Disease, Cognitive Impairment
Feasibility Trial of a Mediterranean Diet Pattern to Prevent Cognitive Decline
By doing this study, researchers hope to learn if older adults with and without cognitive impairment can adhere to a Mediterranean diet.
- Trial name
- NCT02921672
- Testing
- Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Vitamin D Deficiency, Cognitive Decline
High-dose Vitamin D Supplements in Older Adults
This Phase II randomized clinical trial aims to test if supplementation with high dose oral vitamin D will successfully correct vitamin D insufficiency, compared to treatment with standard (RDA) dose vitamin D in a diverse…
- Trial name
- NCT03613116
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of California, Davis
Brain Infarction, Hypertension
Angiotensin II Receptor Blockers (ARB) and ACE Inhibitors (ACEI) on Silent Brain Infarction and Cognitive Decline
The purpose of this study is to elucidate whether or not angiotensin II receptor blockers (ARB) are more beneficial or equal to angiotensin converting enzyme inhibitors (ACEI) on development or progression of silent brain…
- Trial name
- NCT00126516
- Testing
- Angiotensin II Receptor Antagonists, Angiotensin-converting Enzyme Inhibitors
- Where
- Japan
- Volunteers
- 395 people
- Sponsor
- Nara Medical University
Cognition Disorders
Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest
In this study the investigator will randomize 273 subjects to deep (<20°C), low (20.1°C-24°C), or moderate (24.1°C-28°C) hypothermia during aortic arch surgery with circulatory arrest.
- Trial name
- NCT02834065
- Testing
- Cardiopulmonary bypass machine
- Where
- 4 sites in United States
- Volunteers
- 273 people
- Sponsor
- Duke University
Aging, Dementia
Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study
The objective of this project is to test the feasibility of using a smartphone app in a community setting through collaborating with community-based organizations.
- Conditions
- Aging, Dementia, Cognitive Decline
- Trial name
- NCT07313540
- Testing
- utmbHealthyBrain Smartphone App
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Hearing Loss, Sensorineural, Bilateral Vestibulopathy
Effect of Hearing Loss and Vestibular Decline on Cognitive Function in Older Subjects
The world population has been growing and aging dramatically, with a rising prevalence of dementia. Worldwide, around 50 million people have dementia, with 10 million new cases added every year.
- Conditions
- Hearing Loss, Sensorineural, Bilateral Vestibulopathy, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- GECkO (NCT04385225)
- Testing
- Longitudinal follow-up
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Rheumatoid Arthritis, Pain
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients
The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF-α or JAK OR physical training of hands has positive impact on neuropsychiatric…
- Conditions
- Rheumatoid Arthritis, Pain, Fatigue, Cognitive Decline
- Trial name
- NeuMRA (NCT04378621)
- Testing
- TNF-α inhibitor OR JAK inhibitor, Hand training
- Where
- Sweden
- Volunteers
- 212 people
- Sponsor
- Vastra Gotaland Region
Aging, Age-Related Cognitive Decline
Multidomain Interventions for Elderly Individuals in Residential Structures
The "Multidomain Interventions to improve the COgnitive and fUNctional well-being of elderly individuals in residential sTructures" (I-COUNT) study aims to test the feasibility and the effectiveness of a multidisciplinary…
- Conditions
- Aging, Age-Related Cognitive Decline, Sarcopenia, Long Term Care Facility
- Trial name
- I-COUNT (NCT06820710)
- Testing
- Physical activity, Cognitive stimulation, Nutritional Intervention
- Where
- 2 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
Cognitive Impairment, Cognitive Decline
A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults
The potential impact of various dietary ingredients to improve cognitive function, mood, well-being, and overall levels of affects are largely undetermined.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders in Old Age, Well-Being, Psychological
- Trial name
- COG (NCT05994391)
- Testing
- LasoperinTM, Placeo
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lindenwood University