Clinical trials: Cognitive Function and Mental Health
Schizophrenia, Schizo Affective Disorder
REACH Study (Recovery Environments: Assessing Cognitive & Brain Health in Community Mental Health)
The purpose of this study is to understand how different types of community-based mental health care affect thinking abilities, daily functioning, and brain activity in adults with schizophrenia and related conditions.
- Conditions
- Schizophrenia, Schizo Affective Disorder, Schizophreniform Disorders
- Trial name
- NCT07006935
- Testing
- Clubhouse Model of Psychosocial Rehabilitation for Serious Mental Illness, Usual Community-Based Mental Health Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Case Western Reserve University
Alzheimer Disease, Mild Cognitive Impairment
A Study of Health Care Use and Costs in Participants With Early Stage Alzheimer's Disease (AD)
The purpose of this study is to learn about health care use, costs, and clinical outcomes over time for amyloid positive participants with early stages of AD in the United States.
- Trial name
- GERAS-US (NCT02951598)
- Testing
- Florbetapir F 18 PET Scan
- Where
- 77 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- Eli Lilly and Company
Cognition, Affect (Mental Function)
PRECOG Pilot Project
This pilot study aims to investigate the chronic effects of a prebiotic blend on cognitive, affective and gut microbiome outcomes in healthy adults aged 60-75 years.
- Conditions
- Cognition, Affect (Mental Function), Gut Microbiome
- Trial name
- NCT06911957
- Testing
- Prebiotic blend
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading
Cognitive Function, Academic Performance
Effect of Omega-3 LCPUFA Intervention on Learning, Cognition, Behaviour and Visual Processing.
The brain is primarily developed in the third trimester of pregnancy, but continues maturing through the late twenties, especially the prefrontal cortex.
- Conditions
- Cognitive Function, Academic Performance, Mental Health
- Trial name
- NCT02240264
- Testing
- Krill oil capsules
- Where
- 17 sites in Netherlands
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Open University
Sarcopenia in Elderly, Rehabilitation Exercise
Effectiveness of Smart-Assisted Rehabilitation Exercise Training on the Physical and Mental Health of Older Adults in Long-Term Care Facilities
The purpose of this clinical trial is to evaluate the effectiveness of a smart-assisted rehabilitation system on the physical and mental health of elderly residents in long-term care facilities through exercise training.
- Conditions
- Sarcopenia in Elderly, Rehabilitation Exercise, Long Term Care
- Trial name
- NCT07197528
- Testing
- Experimental Arm：Smart-assisted rehabilitation exercise system Control Arm：Usual care or routine physical activity
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Heart Failure, Congestive
Heart Failure, Functional and Cognitive Decline, and Psychiatric Symptoms in Nursing Home Patients
Heart failure is very common in the elderly, in whom it may lead to functional and intellectual problems. Functional problems include loss in the ability to perform basic tasks of daily living such as bathing or dressing.
- Trial name
- NCT00182065
- Where
- Canada
- Volunteers
- 586 people
- Sponsor
- McMaster University
Cognitive Function, Memory
A Clinical Trial to Investigate the Efficacy of the Brain Blossom Supplement to Improve Cognitive Function and Memory
This study evaluates the efficacy of BioNatureHealth's Brain Blossom supplement in improving cognitive function and memory in adults aged 50-70 years.
- Conditions
- Cognitive Function, Memory, Cognitive Decline
- Trial name
- NCT07564804
- Testing
- Dietary Supplement: Brain Blossom
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bio Nature Health
Frailty, Mild Cognitive Impairment
E-health Enhanced Motor-cognitive Training for AED Discharged Older Adults With Cognitive Frailty
The goal of this pilot randomized controlled trial is to explore the feasibility of e-health enhanced motor-cognitive interventions for discharged community-dwelling older adults with cognitive frailty in the emergency department…
- Trial name
- NCT05750121
- Testing
- E-health enhanced motor-cognitive training
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment (MCI), Older People
Digital Health and Exercise for Autonomous Longevity Program
Digital HEAL (Health and Exercise for Autonomous Longevity) is a multicomponent training program (combining concurrent training with cognitive stimulation) designed to promote physical fitness and cognitive function in older…
- Trial name
- DigitalHEAL (NCT06722976)
- Testing
- Multicomponent exercise programs
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Cognitive Function, Memory
The Memory and Cognitive Performance Study
The primary purpose of this study is to evaluate the impact of a novel, neuro-protective and neuro-restorative dietary supplement (Braini®) on standardized memory and cognitive performance parameters.
- Conditions
- Cognitive Function, Memory, Brain Health
- Trial name
- NCT04025255
- Testing
- Braini
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Vita Naturel, LLC
Mobility Limitation, Cognitive Impairment
Living Independence Through Functional Training
The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.
- Trial name
- LIFT (NCT07125378)
- Testing
- Task-oriented resistance exercise
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Florida
Depression, Anxiety
Mediterranean-style Dietary Pattern (MDP), Mood and Anxiety
Observational studies and a limited numbers of RCTs have observed that habitual Mediterranean-style dietary pattern (MDP) consumption is associated with improved mental health and cognition.
- Trial name
- MediMood (NCT05927376)
- Testing
- Mediterranean diet, Western diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Sleep Duration, Child Obesity
Effect of Sleep Extension on Body Weight and Learning in Children (More2Sleep)
More2Sleep is a randomized, controlled, parallel trial with two groups (sleep extension vs control) including 142 school-aged children (6-12 years) who have a BMI above average, defined as age- and sex-specific BMI Z-score above…
- Conditions
- Sleep Duration, Child Obesity, Child Development, Child Behavior
- Trial name
- More2Sleep (NCT06341179)
- Testing
- Sleep extension
- Where
- 3 sites in Denmark
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Medication Adherence
A Smartphone App on Medication Adherence
This is an experimental study which aims to explore the effectiveness of a smartphone app for medication adherence (MedAdhere app) among schizophrenic patients for eight weeks.
- Trial name
- App (NCT05892120)
- Testing
- the MedAdhere app
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Mild Cognitive Impairment (MCI)
Effects of Hydroxytyrosol-Rich Olive Polyphenol Dietary Supplement Combined With Mediterranean Diet Adherence on the Cognitive Health of Patients With Mild Cognitive Impairment
Nutrition is an important modifiable risk factor of human cognitive health. Increasing data suggests that certain nutrients or food ingredients, such as plant polyphenols, have the potential to benefit cognitive abilities even in…
- Trial name
- MEDIPHENO-HT (NCT07672938)
- Testing
- Low-Dose Hydroxytyrosol-Rich Olive Juice Polyphenol Supplement, High-Dose Hydroxytyrosol-Rich Olive Juice Polyphenol Supplement
- Where
- Greece
- Volunteers
- 141 people
- Sponsor
- Panhellenic Federation of Alzheimer's Disease and Related Disorders
Mild Cognitive Impairment, Aged
South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention
This study evaluates acceptability and efficacy of multidomain intervention program to prevent cognitive impairment and protect brain health in Korean at-risk elderly.
- Trial name
- SUPERBRAIN (NCT03980392)
- Testing
- Multidomain intervention program
- Where
- 6 sites in South Korea
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Alzheimer Disease, Mild Cognitive Impairment
A Scalable Nutrition Adherence Intervention
Objective 1: To scale-up the nutrition adherence intervention for testing in racially diverse rural communities in North Florida. The investigators hypothesize that: 1.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Adherence
- Trial name
- NCT06121986
- Testing
- Improving Cognitive Aging through Nutrition (ICAN) Adherence Program, Improving Cognitive Aging through Nutrition, Mediterranean diet
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Florida State University
Insomnia, Sleep Disturbance
Exploration of Relationships Between Sleep, Gut Health and Cognition
Our study aims to build on emerging evidence showing relationships between gut health, sleep and brain functions. To achieve this, our study aims to test the feasibility of using non-pharmacological interventions: a…
- Trial name
- NCT05315986
- Testing
- Saffr'Inside; 30mg, Enhanced Sleep Education
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Neurological Disorders, Cognitive Impairment
Validation of the VIRADIA App for Neurological and Cognitive Diagnostics in Virtual Reality
The VIRADIA study aims to validate and assess the reliability of a newly developed Virtual Reality (VR) diagnostic platform designed for neurological and cognitive testing.
- Conditions
- Neurological Disorders, Cognitive Impairment, Motor Impairment, Neurodegenerative Diseases
- Trial name
- VIRADIA (NCT07268079)
- Testing
- VIRADIA - Virtual Reality Diagnostic Platform
- Where
- Slovakia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gametherapy
Testis Cancer, Cognitive Impairment
Mental Health of Men Before and After Testicular Cancer Treatment
This is a prospective observational study, that investigates men diagnosed with testicular cancer before and after treatment. The patients are included at their visit at the Fertility clinic in Horsens, where they deposit semen…
- Conditions
- Testis Cancer, Cognitive Impairment, Sexual Dysfunction
- Trial name
- NCT03880994
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- University of Aarhus