Clinical trials: Cognitive Function and Mental Health
Frailty, Mild Cognitive Impairment
E-health Enhanced Motor-cognitive Training for AED Discharged Older Adults With Cognitive Frailty
The goal of this pilot randomized controlled trial is to explore the feasibility of e-health enhanced motor-cognitive interventions for discharged community-dwelling older adults with cognitive frailty in the emergency department…
- Trial name
- NCT05750121
- Testing
- E-health enhanced motor-cognitive training
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Psychological Stress, Mental Fatigue
Psychophysiological Effects of Green Exercise in Outdoor Green vs. Indoor Control
Core Purpose: Researchers want to learn if walking in an outdoor green environment helps people recover from mental tiredness and stress better than walking indoors.
- Conditions
- Psychological Stress, Mental Fatigue, Cognitive Dysfunction, Emotional Well-being
- Trial name
- GREEN-OI (NCT07379164)
- Testing
- Outdoor Green Group, Indoor Control Group
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lincoln University College
Progressive Multiple Sclerosis
Efficacy of Early Harvest Olive Oil in Cognition of Primary (PPMS) or Secondary (SPMS) Progressive Multiple Sclerosis
To date, no drug therapy has been approved for primary (PPMS) \& secondary (SPMS) progressive multiple sclerosis. The urgent need to find new therapies - if possible with minimal side effects - led us to the search for the…
- Trial name
- NCT04120675
- Testing
- Early Harvest Extra Virgin Olive Oil
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Aristotle University Of Thessaloniki
Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD)
Expanding Access to Cognitive Health Biomarker Testing at Home
The goal of this observational study is to learn whether at-home blood biomarker testing for Alzheimer's disease risk is feasible and acceptable in older adults with cognitive concerns.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD), Subjective Cognitive Decline (SCD), Cognitive Aging
- Trial name
- NCT07594665
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
Schizophrenia, Substance Use
Effects of Physical Activity in Psychosis
Physical health problems are common in schizophrenia with a two- to three-fold increased morbidity and mortality rate, resulting in a 20 years reduction in life expectancy.
- Trial name
- EPHAPS (NCT02205684)
- Testing
- Computer game skills training, Physical activity
- Volunteers
- 126 people
- Sponsor
- Sykehuset i Vestfold HF
Nicotine Dependence, Smoking Cessation
A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence
This study is designed to evaluate the initial evidence for efficacy of the investigational medicine, EVP-6124, to improve smoking cessation outcomes with and without a standard taper of nicotine replacement therapy (NRT) in…
- Trial name
- NCT01480232
- Testing
- EVP-6124, NicoDerm Patch (Active), Brief Supportive and Behavioral Treatment
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- A. Eden Evins
Sleep Disorders, Frailty
Impact of Sleep Disorders and Digital Support on Older People's Health
The goal of this observational study is to learn about the effects of sleep disorders on health and ageing in older people over the age of 65.
- Conditions
- Sleep Disorders, Frailty, Cognitive Impairment, Quality of Life
- Trial name
- SOMNUS-DARE (NCT06944600)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Parma
Mild Cognitive Impairment
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
This study is a randomized, single-blind, controlled trial that will test a multilevel intervention, Tiempo Juntos para la Salud, (Time Together for Health) designed to promote moderate-intensity physical activity; theoretically…
- Trial name
- NCT05030948
- Testing
- Tiempo Juntos Intervention
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- University of Pennsylvania
Mobility, Depressive Symptoms
Effectiveness of AMICOPE Intervention to Maintain Self-Perceived Health and Intrinsic Capacity in Older People
In their day to day, persons do from simple to more or less complicated tasks and activities (ie: stand from a chair, open a door, shopping, read, drive, play chess, remind an appointment...).
- Conditions
- Mobility, Depressive Symptoms, Nutrition, Healthy, Cognitive Decline
- Trial name
- EFICIS (NCT05249504)
- Testing
- VIVIFRAIL, Nutrition, Psychology
- Volunteers
- 212 people
- Sponsor
- Fundacio Salut i Envelliment UAB
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment Dyadic Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT05144516
- Testing
- Behavioral: COPE +
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Mild Cognitive Impairment, Dementia, Mild
The Brain Health Champion Study
6-month, randomized, controlled investigation measuring the effect of increased clinical contact and personalization compared to standard physician counseling on adherence to consensus-based, brain health recommendations for…
- Conditions
- Mild Cognitive Impairment, Dementia, Mild, Subjective Cognitive Decline, At Risk for Cognitive Decline
- Trial name
- BHC (NCT03772977)
- Testing
- Brain Health Champion
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cognitive Remediation, Neuropsychology
Longitudinal Neurocognitive, Psychosocial and Health-related Quality of Life Assessment in Advanced Cancer Survivors Treated With Immunotherapy and the Efficacy of Integrative Neurocognitive Remediation Therapy
Since 2010, the field of immunotherapy has grown substantially, leading to a growing population of long-term cancer survivors treated with immunotherapy.
- Conditions
- Cognitive Remediation, Neuropsychology, Quality of Life, Psycho-Oncology
- Trial name
- CognIT (NCT05667857)
- Testing
- Integrative neurocognitive remediation therapy
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Mild Cognitive Impairment
Exercise Training to Improve Cognitive Function
This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.
- Trial name
- NCT03824639
- Testing
- Structured exercise, Health Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Aging, Aging Well
100-Year Human Aging Study
The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo…
- Conditions
- Aging, Aging Well, All-Cause Mortality, Mortality
- Trial name
- NCT07563777
- Testing
- Comprehensive Multi-System Clinical Screening
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Chronic Inflammation, Chronic Pain
Gulf War Illness Inflammation Reduction Trial
The primary objective of this clinical trial is to determine if treatment with an anti-inflammatory drug (delayed-release prednisone) improves the health-related quality of life (HRQOL) of veterans with Gulf War Illness (GWI).
- Conditions
- Chronic Inflammation, Chronic Pain, Fatigue, Cognitive Impairment
- Trial name
- GWIIRT (NCT02506192)
- Testing
- Modified-Release Prednisone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Oral Health
A Study on the Correlation Between Oral Health and Delirium in Surgical Inpatients
Delirium is a clinical syndrome characterized by acute attention deficits, altered consciousness, and fluctuating cognitive dysfunction, typically triggered by multifactorial causes such as physical illness, medication use, or…
- Trial name
- NCT06969092
- Testing
- Oral Frailty
- Where
- China
- Volunteers
- 550 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Older Adults, Depression
Educational and Cultural Engagement and Incidence of Health Adverse Events
This study evaluated if the social and cultural activities decrease the incidence of dementia and frailty conditions.
- Conditions
- Older Adults, Depression, Cognitive Decline
- Trial name
- NCT03987360
- Testing
- Observational
- Where
- Canada
- Volunteers
- 30,000 people
- Sponsor
- Jewish General Hospital
Cognitive Function, Academic Performance
Effect of Omega-3 LCPUFA Intervention on Learning, Cognition, Behaviour and Visual Processing.
The brain is primarily developed in the third trimester of pregnancy, but continues maturing through the late twenties, especially the prefrontal cortex.
- Conditions
- Cognitive Function, Academic Performance, Mental Health
- Trial name
- NCT02240264
- Testing
- Krill oil capsules
- Where
- 17 sites in Netherlands
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Open University
Stress, Cognitive Impairment
Mindfulness-Based Health Promotion Program for Educators (MBHP - Educa).
In the last few decades, the world has seen a significant increase in the occurrence of occupational diseases related to Burnout Syndrome (professional exhaustion) and stress in educators.
- Conditions
- Stress, Cognitive Impairment, Burnout Syndrome
- Trial name
- Mindfulness (NCT03839030)
- Testing
- MBHP-Educa
- Where
- Brazil
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Marcelo Demarzo, MD, PhD
Mild Cognitive Impairment, Gingivitis
eDENT Oral Health- the Gateway to Quality of Care and Everyday Life at Old Age
The investigators will present a new strategy for working with oral health for the group of elderly people with various degrees of mild cognitive impairments.
- Conditions
- Mild Cognitive Impairment, Gingivitis, Periodontal Diseases
- Trial name
- NCT06011564
- Testing
- Reminder function on Android computer tablet
- Where
- Sweden
- Volunteers
- 213 people
- Sponsor
- Blekinge Institute of Technology