Clinical trials: Cognitive Function and Mental Health
Traumatic Brain Injury
Predicting Cognitive and Emotional Health From Neurocircuitry Following TBI
Abnormalities in structural and functional connectivity between brain regions have been suggested as putative biomarkers of mild traumatic brain injury (TBI) and significant contributors to neuropsychological functioning and…
- Trial name
- NCT01803048
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Fatigue, Cognitive Function
Radicle Energy VBMTM: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes
Radicle Energy VBMTM: A randomized, double-blind, placebo- controlled direct-to-consumer study assessing the impact of health and wellness products on fatigue and related health outcomes.
- Conditions
- Fatigue, Cognitive Function, Global Mental Health, Sleep Disturbance
- Trial name
- NCT07653724
- Testing
- Energy Active Product 1
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Schizophrenia, Bipolar Disorder
Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental Illness
Many individuals with serious mental illness have difficulty accurately interpreting interpersonal cues and effectively engaging in social exchanges.
- Conditions
- Schizophrenia, Bipolar Disorder, Depressive Disorder, Major, Stress Disorder, Post-Traumatic
- Trial name
- NCT05491538
- Testing
- Social Cognition and Interaction Training-Work Edition (SCIT-WE)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Cognitive Dysfunction
Effects Of An 8-Weeks Mindfulness-based Intervention In Individuals With Subjective Cognitive Decline
The European Commission Horizon 2020 programme has funded the SCD-WELL trial to investigate the efficacy of mindfulness-based training to reduce anxiety in individuals with Subjective Cognitive Decline (SCD), in comparison to an…
- Trial name
- SCD-WELL (NCT03005652)
- Testing
- Mindfulness weekly courses for 8 weeks, Health education weekly courses for 8 weeks
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Breast Cancer, Breast Neoplasms
Mental and Cognitive Health and Physical Activity in the Perioperative Breast Cancer Setting
This study evaluates the complex relationships between mental health, cognitive function, and physical activity before surgery in patients with stage I-III breast cancer.
- Conditions
- Breast Cancer, Breast Neoplasms, Cancer, Breast, Cancer of the Breast
- Trial name
- NCT06595901
- Testing
- Actigraph, Questionnaires, BrainBaseline application
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Cognition, Multiomics
Probiotic Research: Open-label Functional Intervention and Longitudinal Evaluation in Healthy Adults
This study is a pre-post, open-label cohort study designed to investigate how a food-grade probiotic supplement affects biological measurements and wellbeing in healthy adults.
- Conditions
- Cognition, Multiomics, Microbiome Analysis, Metabolome
- Trial name
- PROFILE (NCT07457242)
- Testing
- Probiotic Supplementation (Lactobacillus plantarum)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- OneCarbon
Cognitive Function, Depression in Old Age
Computer Presented and Physical Exercises to Maintain Cognitive Function and Emotional Health in Older Adults
The aim of this study is to investigate and compare how 18-weeks of computer-based brain training and physical exercise together can improve physical performance, cognitive function and mood in older adults in a cross-over design…
- Trial name
- NCT04404621
- Testing
- Physical exercise (PE) training and computer-based brain (CBB)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yale University
Mental Health, Cognition
Bio-Experiential Spaces for Mental Health in Healthworkers
Recharge Rooms are immersive, biophilic private spaces designed to ameliorate trauma, anxiety, and stress. They feature multisensory input that is inspired by nature, as has previously been found to confer physiological benefits.
- Conditions
- Mental Health, Cognition, Anxiety
- Trial name
- NCT05227352
- Testing
- Biophilic design experience
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anxiety Disorder, Cognitive/Functional Effects
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical…
- Conditions
- Anxiety Disorder, Cognitive/Functional Effects, Colorectal Cancer, Depression
- Trial name
- CHALLENGE (NCT00819208)
- Testing
- exercise intervention, counseling intervention, educational intervention
- Where
- 47 sites in United States, Australia and 4 more
- Volunteers
- 889 people
- Sponsor
- Canadian Cancer Trials Group
Aging, Mild Cognitive Impairment
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week…
- Conditions
- Aging, Mild Cognitive Impairment, Hypertension
- Trial name
- NCT06307574
- Testing
- bpMedManage
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Cognitive Impairment, Healthy Participants
Exercise-Modulated Cognitive Hormones
Investigating the influence of a 12-week exercise regimen structured thrice weekly on cognitive capacity, and related hormones like Leptin, Irisin, BDNF hormones, antioxidant status, and inflammatory cytokines, whether these…
- Trial name
- NCT07341568
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Saud University
Thyroid Diseases, Cognition Disorders
Mohawk Culture, Behavior, Toxicant Exposure and Health
This study will determine the pathways between Mohawk cultural identification and specific behaviors related to pollutant exposure, and determine the effects of these factors and the pollutant exposure on physiologically and…
- Trial name
- NCT00043238
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Mild Cognitive Impairment (MCI), Sarcopenia
Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance.
- Trial name
- NCT06828926
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio University
Post-Traumatic Stress Disorder
Therapeutic Effects of the Processing of Positive Memories Technique on Posttrauma Health
The current study will examine daily-level impacts of a technique addressing positive memory retrieval on thoughts, feelings, and health among individuals with trauma experiences.
- Trial name
- PPMT (NCT06680193)
- Testing
- Processing of Positive Memories Technique
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Texas, Denton, TX
Type 2 Diabetes Mellitus (T2DM), Cognitive Impairment
Exercise and PPARGC1A rs8192678 in Older Adults With Type 2 Diabetes and Cognitive Impairment
This completed single-arm interventional study evaluated changes in metabolic control, cognitive function, and health-related physical fitness following a 12-week combined aerobic and resistance exercise program in older adults…
- Trial name
- Association Be (NCT07711834)
- Testing
- Combined aerobic and resistance exercise
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Harbin Sport University
Stroke, Acute
Health Disparities in Stroke Patients and Their Families: a Longitudinal Multicenter Study (HDSS)
The meeting point of the patient and his/her immediate family with the health care system is complicated and traumatic. While having to deal with medicalization geared towards providing evidence-based and cost-effective medical…
- Trial name
- HDSS (NCT03330652)
- Where
- 4 sites in Israel
- Volunteers
- 600 people
- Sponsor
- Sheba Medical Center
Dementia, Cognitive Dysfunction
Preventing Loss of Independence Through Exercise in Community Living Centers
Approximately 40,000 older Veterans with complex care needs receive long-term care in VA Community Living Centers (CLCs). Many CLC staff have limited specialized training to engage Veterans with dementia.
- Trial name
- PLIE-CLC (NCT06972004)
- Testing
- Preventing Loss of Independence through Exercise (PLIE)
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development