Clinical trials: Cognitive Function and Mental Health
Autosomal Recessive Disorder (Genetic Carriers of PKU)
PKU Carriers Trial (Pilot Study): Impact on Cognition, Mental Health, Blood Pressure and Metabolism
This is a clinical intervention pilot/feasibility study of PKU carriers (cases) and non-carriers (controls). Upon completing the informed consent process, participants will complete baseline measures of chronic mental health…
- Trial name
- NCT05958784
- Testing
- L-Phenylalanine
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment a Patient-Caregiver Behavioral Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT04826315
- Testing
- COPE +
- Where
- United States
- Sponsor
- Duke University
Mild Cognitive Impairment (MCI), Dementia
Exploring the Impact of Dementia Prevention Programs Using Robots as Intervention Tools on Community Elderly
The purpose of this study is to intervene in the cognitive functions of the community elderly through the "Robot Dementia Prevention Course" training.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Cognitive Decline, Psychological Well-being
- Trial name
- NCT06984458
- Testing
- Robot Dementia Prevention Course
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Concussion (Diagnosis), Concussion Post Syndrome
Female Concussion Head Cooling
This research is being done to examine the benefits of a 28 day head cooling intervention on cognition, inflammation of the brain, sleep quality, menstrual symptom interaction, and mood in acutely concussed females.
- Conditions
- Concussion (Diagnosis), Concussion Post Syndrome, Concussion, Mild
- Trial name
- NCT07303933
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Penn State University
High Intensity Interval Training, Overweight and Obesity
The HIIT Cognition Study
This pilot study is a randomized control trial to test the effects of a 14-week home-based virtual, interactive high intensity interval training (HIIT) exercise intervention on cardiometabolic and cognitive outcomes in sedentary…
- Conditions
- High Intensity Interval Training, Overweight and Obesity, Metabolic Disease, Cognition
- Trial name
- NCT05137990
- Testing
- HIIT Exercise Intervention, Stretching Intervention
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Anxiety Symptoms
Effect of IATP on Cognitive Functioning in Anxious Older Adults.
Older adults with anxiety symptoms was found to be associated with greater risk of dementia. Interventions targeting signs as early as in the pre-symptomatic phase could be most effective in early prevention of dementia.
- Trial name
- NCT04413513
- Testing
- Integrated Attention Training Program (IATP), Health Education
- Where
- Hong Kong
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Psychotic Disorders, ADHD
Cognitive Remediation in Forensic Mental Health Care
Forensic patients often display cognitive deficits, particularly in the domain of executive functions, that represent a challenge to forensic rehabilitation.
- Conditions
- Psychotic Disorders, ADHD, TBI (Traumatic Brain Injury), Aggression
- Trial name
- CRFMHC (NCT04610697)
- Testing
- Cognitive Remediation, Active Control
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- NCT07592117
- Testing
- Cool roof
- Where
- Fiji
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Brain Injuries, Cognitive Impairment
Occupational Therapy and Cognitive Challenges After Brain Injury
Background: There is a need for standardized interventions in community rehabilitation that can improve everyday task performance for older adults with cognitive challenges after acquired brain injury.
- Trial name
- NCT05148247
- Testing
- The Perceive, Recall, Plan and Perform System of Intervention
- Where
- 2 sites in Norway
- Volunteers
- 6 people
- Sponsor
- Norwegian University of Science and Technology
Mental Health, Neurodevelopment
Investigating the Impacts of Early Life Experience on the Brain & Behaviour
The aim of this study is to learn more about how early life experience influences the brain, behaviour, and the immune system later in life.
- Conditions
- Mental Health, Neurodevelopment, ADHD, Autism
- Trial name
- NCT06823492
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
CKD Stage 4, CKD Stage 5
Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease.
This observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease ].
- Conditions
- CKD Stage 4, CKD Stage 5, Frailty, Cognitive Impairment
- Trial name
- NCT05705011
- Where
- Romania
- Volunteers
- 240 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Critical Illness
Psychological Support Based on Positive Suggestions (PSBPS) on Mental Health Morbidity and Cognitive Function
The Researchers are trying to evaluate efficacy of a psychotherapeutic approach that can be applied to those who are critically ill.
- Trial name
- NCT04045210
- Testing
- Psychological Support Based on Positive Suggestions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Mayo Clinic
Mild Cognitive Impairment (MCI), Dementia
Culturally Familiar Nostalgic VR Cognitive Training for Older Adults
This randomized controlled trial investigates the effects of a nostalgia-based cognitive training intervention delivered via Virtual Reality (VR) on emotional well-being and cognitive functioning among community-dwelling older…
- Conditions
- Mild Cognitive Impairment (MCI), Dementia, Cognitive Decline, Psychological Well-being
- Trial name
- NCT06973551
- Testing
- Brain Health Nostalgic VR Program
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- National Taiwan Normal University
Cognitive/Functional Effects, Depression
Study of Physical and Mental Health of Older Patients With Newly Diagnosed Cancer
RATIONALE: Gathering information from older patients with newly diagnosed cancer may help doctors learn more about the risks of functional decline.
- Conditions
- Cognitive/Functional Effects, Depression, Hematopoietic/Lymphoid Cancer, Malnutrition
- Trial name
- NCT00769951
- Testing
- medical chart review, questionnaire administration, cognitive assessment
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Case Comprehensive Cancer Center
Alzheimer Disease
Effects of a Cognitive-Engaging Strength Training Program on Health, Physical Condition, and Quality of Life in People With Alzheimer's Disease
The primary objective of this project is to examine the impact of a strength training program with high cognitive demands on cognitive function, motor skills, physical fitness, and quality of life in individuals with Alzheimer's…
- Trial name
- NCT07022431
- Testing
- Interval strength training
- Volunteers
- 34 people
- Sponsor
- University of Seville
Frailty, Cognitive Decline
Precision Stratification for Frailty and Cognitive Decline
The Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB) trial aim to test the effectiveness of an exercise, cognitive and lifestyle intervention amongst older adults over a 12-weeks…
- Trial name
- NCT07081282
- Testing
- Care4Senior mobile Application, Intensive Aerobic Resistance Training and Brain Health (CIRTAB), Centre-Based Exercise Health Session
- Where
- Singapore
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Cognitive Impairment, Healthy Participants
Exercise-Modulated Cognitive Hormones
Investigating the influence of a 12-week exercise regimen structured thrice weekly on cognitive capacity, and related hormones like Leptin, Irisin, BDNF hormones, antioxidant status, and inflammatory cytokines, whether these…
- Trial name
- NCT07341568
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Saud University
Huntington Disease
Family Health After Predictive Huntington Disease (HD) Testing
The purpose of this study is to identify health management concerns and needs of family members of asymptomatic and symptomatic persons with mutation in the gene for Huntington Disease (HD).
- Trial name
- NCT00075140
- Testing
- Mutation in the gene
- Where
- United States
- Volunteers
- 422 people
- Sponsor
- National Institute of Nursing Research (NINR)
Postoperative Cognitive Dysfunction, Chronic Post Operative Pain
Chronic Postsurgical Pain, Postoperative Cognitive Dysfunction and Resilience
"Brain damage" and "memory loss" are main concerns of people undergoing surgery. In fact, many older people undergoing different types of non-cardiac surgeries (including orthopedic surgeries) present a significant decline in…
- Conditions
- Postoperative Cognitive Dysfunction, Chronic Post Operative Pain, Satisfaction, Patient, Coping Behavior
- Trial name
- ArthroCaP (NCT05614271)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University