Clinical trials: Cognitive Functions
Brain-derived Neurotrophic Factor (BDNF), Cognitive Function
Whole Coffee Fruit Concentrate Pilot Study 1
The purpose of this pilot study is to evaluate the potential effects of whole coffee fruit concentrate (WCFC, Neurofactor), a product that elevates circulating brain-derived neurotrophic factor (BDNF), on cognition and mood in…
- Conditions
- Brain-derived Neurotrophic Factor (BDNF), Cognitive Function, Affect
- Trial name
- WCFC (NCT01965795)
- Testing
- Whole Coffee Fruit Concentrate (WCFC), Nutrim
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Aging
Pilot Intervention With Near Infrared Stimulation
The current study will test whether age-related cognitive and mood changes in older adults and those will be affected by near infrared (NIR) stimulation.
- Trial name
- NCT03551392
- Testing
- Medx Console System, Vielight 810 intranasal stand alone unit
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Function, Mood
Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults
Epigallocatechin gallate (EGCG) is the most abundant catechin (sometimes referred to as tea flavonoids) in green tea extract. A review by Nagle et al (2006) identifies that a large amount of research indicates EGCG (amongst other…
- Trial name
- NCT00981292
- Testing
- EGCG
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Impairment, Dementia
A Digital Life Story to Support Person-centred Care for Older Adults With Dementia Perspectives
Person-centred care can be supported when healthcare professionals access and actively use the information recorded in a life story. Active use of the life story can create security for a person with dementia and their carers.
- Trial name
- NCT06337201
- Testing
- Test of the application Min Memoria
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Mood, Cognitive Change
Investigating the Effects of Dietary Phospholipids on Measures of Human Brain Health and Psychological Wellbeing
The aim of this study is to investigate the effects of 6- and 12-week supplementation of a bioactive whey protein concentrate drink containing dairy phospholipids on cognitive function and mood in healthy young to middle aged…
- Conditions
- Mood, Cognitive Change, Well-Being, Psychological
- Trial name
- NCT06107075
- Testing
- Active
- Where
- United Kingdom
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Dementia
BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006)
This study will evaluate functional magnetic resonance imaging (fMRI) and methods for measuring drug induced changes in cerebral blood flow as biomarkers for attention-improving drugs.
- Trial name
- NCT00887601
- Testing
- MK3134, Donepezil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Mild Cognitive Impairment
Effects of Tai Chi on Cognition, I-ADLs, and HRQOL in Older People With MCI
The prevalence of older people with cognitive decline is increasing since the aging population is growing substantially worldwide. Cognitive impairment places older adults at high risk for functional disability.
- Trial name
- NCT03404765
- Testing
- Tai Chi
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cognitive Aging
Elucidating How Physical Activity and Sleep Relate to Optimal Cognitive Ageing
Increased longevity is one of the greatest success stories in public health. However, ageing is accompanied by cognitive decline which affects people's daily functioning and, if it develops to dementia, their ability to live…
- Trial name
- PASOCA (NCT05455229)
- Where
- Belgium
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Alzheimer Disease, Cognitive Impairment
Biomarker Exploration in Aging, Cognition and Neurodegeneration
The purpose of this research study is to understand the factors that underlie changes in thinking and memory with increasing age.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- BEACoN (NCT03860857)
- Testing
- Amyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Schizophrenia
Enhancing Synaptic Plasticity and Cognition in Schizophrenia
To explore: (a) if physical exercise (sports) combined with cognitive training leads to (superior) improvement of cognition in schizophrenia compared to sports or cognitive training alone (b) if a sports program alone or in…
- Trial name
- EXERCISE-II (NCT01776112)
- Testing
- Exercise, TableSoccer
- Where
- Germany
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Dementia, Mild Cognitive Impairment
Dual-task Exercise in People With Cognitive Impairment
The purpose of this study is to explore how performing two exercise-based tasks simultaneously (dual-task exercise) affects the neurovascular and cognitive responses of people with cognitive impairment, which is a growing concern…
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adults
- Trial name
- NCT06389812
- Testing
- Dual-task exercise traning
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Brain Aging, Cerebrovascular Function
AKG and Brain Health in Aging
This proposal will test the hypothesis that AKG supplementation will improve NGVC responses and cognitive performance in older adults.
- Trial name
- NCT07861867
- Testing
- Calcium AKG
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Major Depressive Disorder
Treatment Resistant Geriatric Depression in Primary Care
This study involves collaboration between McLean Hospital, Geriatric Medicine at the Cambridge Health Alliance (CHA) and other sites within the Partners and Harvard Medical School network.
- Trial name
- NCT01392287
- Testing
- Memantine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Athletic Performance, Upper Extremity
DEVELOPMENT AND PSYCHOMETRIC EVALUATION OF THE NEUROCOGNITIVE UPPER EXTREMITY TESTS: A RELIABILITY AND VALIDITY STUDY
The goal of this observational study is to develop an upper extremity neurocognitive performance test battery, determine its reliability and validity, and investigate the effect of neurocognitive load on test performance in…
- Conditions
- Athletic Performance, Upper Extremity, Cognition, Physical Functional Performance
- Trial name
- NCT07579676
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Huntington Disease
Study of Biomarkers That Predict the Evolution of Huntington's Disease
Huntington's disease (HD) is a rare, autosomal dominant, progressive neurodegenerative disorder typically becoming noticeable in middle age.
- Trial name
- BIOHD (NCT01412125)
- Testing
- Huntington patient evaluation, Healthy subject evaluation
- Where
- France
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Damage, Chronic
The Effect of tDCS on Subcortical Brain Functioning
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain abilities related to cognition, emotion and/or physical functioning in individuals with subcortical brain damage.
- Trial name
- NCT01602276
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Mild Cognitive Impairment (MCI)
Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Adults: A Pilot Study
The incidence of cognitive impairment and its burden are increasing with a rapidly ageing population. In Singapore, the prevalence of dementia among older adults aged 60 and above is approximately 10%, which will translate to…
- Trial name
- NCT07099040
- Testing
- Social support, Health coaching, Physical Activity
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Healthy, Modeling Psychosis
Gene-Environment-Interaction: Influence of the COMT Genotype on the Effects of Different Cannabinoids
The study evaluates the gene-environment interaction of the COMT-genotype on the effects of the phytocannabinoids delta-9-tetrahydrocannabinol, cannabidiol or a combination of both on induction of psychotic symptoms…
- Trial name
- NCT02487381
- Testing
- delta-9-tetrahydrocannabinol, Cannabidiol
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Multiple Sclerosis
Protective Stepping in People With MS
Falls are common in Veterans with multiple sclerosis (MS), and current rehabilitation approaches to reduce falls are inadequate.
- Trial name
- PRO-STEP (NCT03551665)
- Testing
- Protective step training
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Physical Inactivity
Effects of Exercise With Different Music Frequencies
This study will explore the impact of different music frequencies applied during yoga based exercises on physical performance and cognitive status in inactive young adults.
- Trial name
- NCT07006857
- Testing
- Exercise, Low Frequency, High Frequency Music
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biruni University