Clinical trials: Cognitive Health, open to volunteers
Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea
Does the Timing of Insomnia Therapy (CBT-i) Impact the Usage and Compliance of Upper Airway Stimulation (UAS) Treatment of Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea, or OSA, affects over 1 billion adults worldwide. OSA is one of many sleep disorders. Individuals can suffer from more than one sleep disorder at a time.
- Conditions
- Obstructive Sleep Apnea, Comorbid Insomnia and Sleep Apnea, Insomnia
- Trial name
- CBT-i and UAS (NCT07838870)
- Testing
- Digital Cognitive Behavioral Therapy (CBT-i)-COAST
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Kaffenberger
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Stroke, Cognitive Decline
Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE)
This study is a phase III, prospective, placebo-controlled randomized clinical trial involving 8,518 subjects with low to moderate stroke risk, followed for 3 years in Brazil.
- Trial name
- PROMOTE (NCT05155137)
- Testing
- Drug Capsule (Valsartan + Amlodipine + Rosuvastatin), Stroke Riskometer
- Where
- 2 sites in Brazil
- Volunteers
- 8,518 people
- Sponsor
- Hospital Moinhos de Vento
Sickle Cell Disease, Cognitive Impairment
Cognitive Remediation Intervention to Prepare for Transition of Care
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for…
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy
- Trial name
- NCT05336201
- Testing
- CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Cognitive Dysfunction, Aging
Study on Aging and Cognitive Impairment in China
Background: By the end of 2022, China had about 280 million people aged 60 and older, making up 19.8% of the population. This number is projected to exceed 300 million by the end of the 14th Five-Year Plan and 400 million by…
- Trial name
- HAPCAD (NCT06679296)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Mild Cognitive Impairment (MCI), Older People
Digital Health and Exercise for Autonomous Longevity Program
Digital HEAL (Health and Exercise for Autonomous Longevity) is a multicomponent training program (combining concurrent training with cognitive stimulation) designed to promote physical fitness and cognitive function in older…
- Trial name
- DigitalHEAL (NCT06722976)
- Testing
- Multicomponent exercise programs
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Beira Interior
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Obsessive Compulsive Disorder (OCD), CBT
Brief Cognitive Behaviour Therapy (CBT) for Adolescent OCD in Routine Clinical Practice
Obsessive-Compulsive Disorder (OCD) is a common and often disabling condition in young people, characterised by distressing, intrusive thoughts, images or urges, and repetitive behaviours intended to reduce discomfort or prevent…
- Trial name
- NCT06983301
- Testing
- Brief Cognitive Behavioural Therapy (CBT) for OCD
- Where
- 3 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Oxford
Dementia, Mild Cognitive Impairment (MCI)
Combating Alzheimer's Through Sleep and Exercise
The Combating Alzheimer's through Sleep and Exercise (CASE) study is an exploratory, hypothesis-generating trial designed to: (1) assess whether improvements in sleep are associated with improvements in cognitive performance and…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Alzheimer's Dementia (AD)
- Trial name
- CASE (NCT04855630)
- Testing
- Elemind Neuromodulation Headband, Exercise Routine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Miami
Prenatal Anxiety, Prenatal Depression
Effectiveness of an Online Biopsychosocial Intervention to Improve Well-being and Mental Health During Pregnancy
This study aims to develop and implement a preventive intervention through a mobile application to help pregnant women feel better emotionally and cope with the changes of pregnancy in a more positive way.
- Conditions
- Prenatal Anxiety, Prenatal Depression, Wellbeing, Obstetrical Complications
- Trial name
- BienGestar (NCT06871397)
- Testing
- Biopsychosocial Cognitive Behavioral Intervention
- Where
- Spain
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Healthy Adults
Health Properties of Pecan Nut Consumption
The main goal of this clinical study is to see if consuming pecan nuts will result in improvements in overall body metabolism such as in blood lipids, markers of inflammation, blood pressure, cognitive performance and changes in…
- Trial name
- NCT07227259
- Testing
- pecan nut
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Elderly (People Aged 65 or More)
Effects of Physical Exercise and Cognitive Training on Quality of Life in Elderly Adults
The aim of the study is to investigate the effectiveness of three different types of intervention, based on physical exercise and/or cognitive stimulation or training, on quality of life, cognition and mobility, on a population…
- Trial name
- HELIOS (NCT07244536)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Italy
- Volunteers
- 156 people
- Sponsor
- University Hospital of Ferrara
Diabete Type 1, Diabete Type 2
Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals With Prediabetes and Diabetes Mellitus
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of the probiotic LP-LDL® (Lactobacillus plantarum ECGC 13110402) on lipid metabolism, glycemic control, inflammatory biomarkers, and…
- Conditions
- Diabete Type 1, Diabete Type 2, Prediabetes
- Trial name
- NCT07373392
- Testing
- Lactobacillus plantarum ECGC 13110402
- Where
- 2 sites in Denmark
- Volunteers
- 210 people
- Sponsor
- Aalborg University
Sleep Hygiene, Sarcopenia
Sleep Hygiene, Sarcopenia, and Cognitive Function in Respiratory Disease
We aim to clarify the relationship between sleep hygiene and the onset of sarcopenia or cognitive dysfunction using sleep time, arousal, and sleep quality as indicators in COPD or IPF patients, and clarify the effects of sleep…
- Conditions
- Sleep Hygiene, Sarcopenia, Cognitive Function, COPD
- Trial name
- NCT05193136
- Where
- Japan
- Volunteers
- 120 people
- Sponsor
- National Hospital Organization Minami Kyoto Hospital
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD)
Expanding Access to Cognitive Health Biomarker Testing at Home
The goal of this observational study is to learn whether at-home blood biomarker testing for Alzheimer's disease risk is feasible and acceptable in older adults with cognitive concerns.
- Conditions
- Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD), Subjective Cognitive Decline (SCD), Cognitive Aging
- Trial name
- NCT07594665
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Virginia
ADHD
Evaluating a Digital Cognitive Training Intervention in Adults With ADHD
The goal of this clinical trial is to evaluate whether a digital cognitive training program can reduce symptoms of ADHD, improve executive functioning, and decrease problematic internet use in adults aged 18-65 with a diagnosis…
- Trial name
- NCT07050225
- Testing
- Digital Cognitive Training, Digital Non-cognitive Training Intervention
- Volunteers
- 52 people
- Sponsor
- McMaster University
Rheumatic Diseases, Arthritis
Pain-Sleep in Rheumatic Disease
Overall, our understanding of how pain and sleep are experienced and how they can be treated in teenagers with rheumatic diseases is limited.
- Conditions
- Rheumatic Diseases, Arthritis, Lupus, Lupus Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07775612
- Testing
- Better Nights, Better Days for Youth
- Volunteers
- 43 people
- Sponsor
- The Hospital for Sick Children
Chronic Pain
Integrating Nonpharmacologic Strategies for Pain With Inclusion, Respect, and Equity
INSPIRE creates a trilingual mobile app and telehealth coaching program to promote non-pharmacologic strategies for pain management with Black, Chinese, and Latinx communities in the San Francisco Bay Area.
- Trial name
- INSPIRE (NCT06183281)
- Testing
- CBT, Mindfulness, and Movement
- Where
- 2 sites in United States
- Volunteers
- 586 people
- Sponsor
- University of California, San Francisco