Clinical trials: Cognitive Investigation
Cognitive Impairment
Cognitive Remote Assessment Using FLAME (CRA-FLAME)
We aim to use a multimodal approach comprising conventional neuropsychological cognitive tests, fluid and imaging biomarker data, to explore their association with the FLAME unsupervised cognitive computerized assessment.
- Trial name
- NCT05624632
- Testing
- Remote cognitive testing
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Traumatic Brain Injury, Acquired Brain Injury
Comparative Utility of Clinical Balance Measures in Traumatic Brain Injury
The purpose of this research study is to investigate how useful three balance tests are in predicting fall risk in the individual with traumatic brain injury (TBI).
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Accidental Falls
- Trial name
- NCT02696538
- Testing
- Functional Gait Assessment, mini-Balance Evaluation Systems Test, Berg Balance Scale
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Cognitive Dysfunction
Optic Nerve Sheath Diameter and Postoperative Cognitive Disfunction at Laparoscopic Surgery
Purpose: Pneumoperitoneum during laparoscopic abdominal surgery increases intra-abdominal pressure (IAP), potentially altering intracranial pressure (ICP) and cerebral oxygenation, with unclear implications for early…
- Trial name
- NCT07264764
- Testing
- Optic nerve sheath diameter (ONSD)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Duzce University
Cerebral Small Vessel Diseases
Retinal, Cerebral and Vascular Precursor Markers of Cerebral Small Vessel Disease.
Cognitive impairment and dementia are primarily due to a combination of vascular brain injury and neurodegenerative lesions. The vascular component is now recognized as a major contributor to the pathophysiology of dementia, with…
- Trial name
- SHIVA-SHARE (NCT05305144)
- Testing
- Vascular and ophthalmological examinations
- Where
- France
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Multiple Sclerosis, Relapsing-Remitting
An Observational Study to Evaluate Quality of Life (QoL) and Influence of Cognitive Status on QoL in Patients With Relapsing-Remitting Multiple Sclerosis (RRMS) During 2 Years Treatment With Rebif New Formulation (RNF)
This is a prospective, non-interventional, multicenter study to evaluate quality of life (QoL) and influence of cognitive status on QoL in subjects with relapsing-remitting multiple sclerosis (RRMS) during two years of treatment…
- Trial name
- MusiClock (NCT01110993)
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Recurrent Depression
Implementation and Evaluation of "Mindfulness-Based Cognitive Therapy" in a Health Care Region in Flanders: a Randomized Clinical Trial
Research project regarding the possibility to implement and the efficacy of a non-drug, psychotherapeutic intervention (MBCT), in preventing relapse/recurrence of depression.
- Trial name
- NCT00259506
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT)
- Where
- Belgium
- Volunteers
- 405 people
- Sponsor
- University Hospital, Ghent
Cognitive Performance
Investigation of How Morning Nutrition Influences Cognitive Performance
This project will assess the effects of the macro-nutrient make-up of morning food intake on cognitive performance using visual analog scale (VAS) measures, behavioral tests, and advanced high-density electrophysiological…
- Trial name
- NCT03169283
- Testing
- Cereal with B glucan, Cereal without B glucan
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Psychogenic Nonepileptic Seizures, Psilocybin
Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures
Psychogenic non-epileptic seizures (PNES) are functional paroxysmal motor disorders that may be clinically suggestive of epilepsy but are not associated with the electroencephysiological and electroencephalographic changes of…
- Trial name
- CRIPSY (NCT06647056)
- Testing
- Psilocybin, MRI
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mild Cognitive Impairment, Mild Dementia
Dementia-friendly Apothecaries as a Resource for Mental Heath in the Elderly
The DARE study (Dementia-Friendly Apothecaries as a Resource for Mental Health in the Elderly) is a multicenter, prospective cohort study aiming to identify individuals with cognitive impairments early in pharmacies and enhance…
- Trial name
- DARE (NCT07504965)
- Where
- Germany
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Type 2 Diabetes Mellitus (T2DM), Cognitive Function
Investigation of Motor Imagery Ability, Body Awareness and Cognitive Functions in Type 2 Diabetes Mellitus
The aim of this study is to examine the relationship between motor imagery skills, body awareness and cognitive functions in individuals with Type 2 Diabetes mellitus.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cognitive Function, Motor İmagery Ability
- Trial name
- NCT06588894
- Testing
- Questionnaire and Physical Exam, Motor Imagery Ability
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kutahya Health Sciences University
Dementia, Mild Cognitive Impairment
Eye Scanning for Safety Driving
This is an experimental study protocol to investigate the use of vision-based assessments like eye-tracking and visual processing tests to evaluate driving ability in older adults with and without dementia.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adults
- Trial name
- NCT06396273
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Aging, Fall Risk Factors
Use of Virtual Reality for the Assessment of Attentional and Reaction Abilities for Fall Risk Evaluation
Aging is a condition characterized by a general decline in physical and cognitive performance, however its effects on various functions are still controversial.
- Conditions
- Aging, Fall Risk Factors, Sleep
- Trial name
- NCT06940245
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Elevated PSA, Prostate Cancer
Prospective Assessment of Image Registration for the Diagnosis of Prostate Cancer
This is a pilot study to determine cancer detection rate of conventional/systematic versus targeted biopsy methods in diagnosis of potentially lethal prostate cancer.
- Trial name
- Paired Cap (NCT02425228)
- Testing
- Targeted biopsy
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Stroke, Stroke Hemorrhagic
FIND Stroke Recovery - A Longitudinal Study
Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life.
- Conditions
- Stroke, Stroke Hemorrhagic, Stroke, Ischemic, Risk Factor, Cardiovascular
- Trial name
- FIND (NCT05708807)
- Testing
- Observational - all
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Göteborg University
Stroke, Cardiovascular Diseases
MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway
Annually 13000 Norwegians experience an ischemic stroke. The number of stroke is anticipated to increase with 50% within 2030 due to a growing number of elderly.
- Conditions
- Stroke, Cardiovascular Diseases, Cardiovascular Risk Factor, Brain Ischemia
- Trial name
- NCT03962127
- Testing
- no intervention
- Where
- 8 sites in Norway
- Volunteers
- 800 people
- Sponsor
- Norwegian University of Science and Technology
Parkinson Disease, Cognitive Dysfunction
A Study to Evaluate the Effects of SAGE-718 in Participants With Parkinson's Disease Cognitive Impairment
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance in participants with Parkinson's disease mild cognitive impairment (PD-MCI).
- Trial name
- NCT05318937
- Testing
- SAGE-718
- Where
- 38 sites in United States
- Volunteers
- 86 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Parkinsons Disease
First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)
This study is researching an experimental drug called ALN-SNCA (called "study drug"). The study is focused on people with early Parkinson's disease, a disorder of the nervous system that affects movement.
- Trial name
- NCT07216066
- Testing
- ALN-SNCA
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 46 people
- Sponsor
- Regeneron Pharmaceuticals
Cognitive Abnormality
Evaluation of a Decision-Support Tool for Blood Biomarker Testing for Alzheimer's Disease in Primary Care
The goal of the current study is to evaluate a decision-support tool intended to help primary care providers (PCPs) communicate with patients about blood biomarker testing for Alzheimer's Disease, enhancing shared-decision making…
- Trial name
- NCT07812337
- Testing
- Shared decision-making support tool
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer Survivors
Evaluation of an Online, Remote Cognitive Battery for Use in Cancer Survivorship
The purpose of this study is to measure changes in cognitive (mental) function in cancer survivors using a brief, reliable, game-like set of tests that can be completed outside the clinic, as an alternative to traditional…
- Trial name
- NCT03674437
- Testing
- Traditional Neurocognitive Assessments, Online Cognitive Battery (Cogsuite)
- Where
- United States
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
ADHD
QbTest Utility for Optimising Treatment in ADHD (QUOTA)
Attention Deficit/Hyperactivity Disorder (ADHD) is a condition that affects 3-5% of young people under 18-years-old. Young people with ADHD have difficulties with attention, impulsivity and hyperactivity that make it harder for…
- Trial name
- QUOTA (NCT03368573)
- Testing
- QbTest
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Nottinghamshire Healthcare NHS Trust
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