Clinical trials: Cognitive Investigation
Alzheimer's Disease
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease
- Trial name
- MINDSET 1 (NCT06976216)
- Testing
- KarXT, KarX-EC
- Where
- 119 sites in United States, Argentina and 17 more
- Volunteers
- 586 people
- Sponsor
- Bristol-Myers Squibb
Vascular Cognitive Impairment no Dementia
Cog-VACCINE: Cognitive Training in Patients With Vascular Cognitive Impairment, no Dementia
This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with subcortical VCIND. Half of participants will receive multi-domain adaptive internet-based training program, while the other…
- Trial name
- Cog-VACCINE (NCT02640716)
- Testing
- multi-domain internet-based adaptive training program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Friendship Hospital
Glycemic Index, Cognitive Performance
Evaluation of the Glycemic Index in 4 Dairy Beverages.
The objective of the study is to evaluate the glycemic index and glycemic load of 4 chocolate milk drinks.
- Trial name
- IG (NCT05204823)
- Testing
- Experimental product, Control product
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Pain, Postoperative, Analgesics, Opioid
Phase 1: Randomized Evaluation of a System to Deliver Mobile Cognitive Behavioral Therapy
The clinical study described in this Clinical Investigation Plan (CIP) will be completed in two stages, Phase I and Phase II. The results of Phase I will confirm patient use of InCaveo's EOA system with integrated mobile CBT but…
- Trial name
- P1RESPECT (NCT04836169)
- Testing
- InCaveo's EOA system with integrated mobile CBT
- Volunteers
- 30 people
- Sponsor
- InCaveo
Cognitive Function, Healthy
Apolipoprotein E (ApoE) and Metabolism
Impaired metabolism and the gene apolipoprotein E (ApoE) are independent risk factors for cognitive impairment and dementia. In humans, there are three major versions of apoE (E): E2, E3, and E4.
- Trial name
- NCT03109561
- Testing
- Resting State Indirect Calorimetry, ApoE, Metabolism
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Lance Johnson
Mild Cognitive Impairment, Delirium
Remote Cognitive Assessment for Surgical Patients
This is a pilot study to evaluate the use of remote cognitive testing to identify patients who may have cognitive vulnerability and may benefit from cognitive care pathways.
- Trial name
- Remote OR (NCT05566275)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, San Francisco
Dementia, Memory, Short-Term
Evaluation of the Effect of Memory-based Reminiscence Therapy
The main objective of this study is to examine the effects of memory-based recall therapy applied to elderly adults diagnosed with Stage 0, 1, and 2 dementia on their mental state, psychological flexibility, and cognitive…
- Trial name
- NCT07073443
- Testing
- Experimental: Memory Therapy Group
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Kahramanmaraş İstiklal University
Cognitive Impairment, Chemobrain
Cognitive Impairment in Treated Breast Cancer Survivors: Possible Approaches
The investigators aim is to conduct a prospective study with three arms, involving non-metastatic breast cancer patients who underwent chemotherapy as part of their treatment and were on a form of hormone therapy at the time of…
- Trial name
- NCT06662474
- Testing
- 1. cognitive stimulation, 2. psychoeducation and cognitive stimulation, 3. no intervention
- Volunteers
- 120 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Mild Cognitive Impairment, Idiopathic Membranous Nephropathy
the Effects of Different Treatment Schemes on Cognitive Function of Patients With Idiopathic Membranous Nephropathy
This study intends to apply prospective, open, single-center, randomized controlled study to evaluate the cognitive status of patients with Idiopathic membranous nephropathy and the influence of different treatment schemes on the…
- Trial name
- NCT06245707
- Testing
- prednisone,methylprednisone and cyclophosphamide, Rituximab
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Beijing Friendship Hospital
Postoperative Delirium
Risk Assessment for Postoperative Delirium
Postoperative delirium (POD) - a temporary state of confusion - is a frequent complication of surgery, which most commonly occurs in elderly patients.
- Trial name
- RAPID (NCT02377115)
- Testing
- Tablet computer application
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Adults With Subjective Memory Complaints
Effects of Tremella Fuciformis on Improvement in Cognitive-Bio-Markers of Cognitive Functions
The objective of this study is to demonstrate the cognitive enhancement effect and safety of Tremella Fuciformis, using the cognitive and clinical indicators (e.g.
- Trial name
- NCT02377024
- Testing
- TF 600mg, TF 1200mg
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Ewha Womans University
Cognitive Decline, Social Isolation
Evaluation of the Wits Workout Wellness Program for Older Adults
About 11% of the U.S. older adult population is at risk for or suffers from subjective cognitive decline. While some factors such as genetics and habitual physiological changes that affect brain health cannot be changed, research…
- Conditions
- Cognitive Decline, Social Isolation, Health Behaviors, Self Efficacy
- Trial name
- NCT04928885
- Testing
- Wits Workout Program, Control Group that receives intervention after the study
- Where
- United States
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Stroke
Neuromodulation Combined With Dual FES Cycling and Cognitive Training After Stroke
This study will evaluate the effects of functional electrical stimulation (FES) cycling, cognitive task training, and non-invasive photobiomodulation on cognitive and upper-limb motor performance in adults after stroke.
- Trial name
- NCT07807176
- Testing
- Functional Electrical Stimulation Cycling, Cognitive Task Training, Transcutaneous Auricular Photobiomodulation
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
General Anesthesia, Elective Laparoscopic Cholecystectomy
The Effect of Positive End-Expiratory Pressure Levels on Perfusion Index and Neurocognitive Functions in Geriatric Patients
With the increasing geriatric population, age-related physiological changes and common comorbidities increase the risk of surgical and anesthesia-related complications in this patient group.
- Trial name
- NCT07505550
- Testing
- PEEP levels
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ankara City Hospital Bilkent
Multiple Sclerosis
Fatigability in Persons With Multiple Sclerosis: Inputs From Cognition, Walking and Coordination
Walking impairments occur in 93% of persons with MS (pwMS) within 10 years of diagnosis. Besides the impact of muscle weakness or hypertonia, one is increasingly aware about the symptom of fatigability.
- Trial name
- NCT05412043
- Testing
- Dance therapy, Psychometric properties (Validity, Reliability) of interlimb coordination- and cognitive-fatigability
- Where
- 2 sites in Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Mild Cognitive Impairment, So Stated, Mild Dementia
Cognitive/Physical Computer-Game Blended Training of Elderly: Neuroscientific LLM Studies
The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities.
- Conditions
- Mild Cognitive Impairment, So Stated, Mild Dementia, Healthy
- Trial name
- LLM-AUTH (NCT02313935)
- Testing
- LLM, FFA, Brain Fitness
- Volunteers
- 581 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Fibromyalgia
The Effectiveness Of BETY In Fibromyalgia
Fibromyalgia Syndrome (FMS) is a nonarticular, chronic rheumatic disorder of unknown etiology characterized by widespread musculoskeletal pain, impaired sleep quality, fatigue and the presence of identified tender points.
- Trial name
- NCT07034417
- Testing
- Exercise, Home exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Aysima Barlak
Panic Disorder, Agoraphobia
A Clinical Trial to Evaluate the Efficacy and Safety of Meltz, a Digital Therapeutic Device, for Improving Panic Symptoms in Patients With Panic Disorder
i. This randomized clinical trial will evaluate the efficacy and safety of Meltz, a digital therapeutic device that provides cognitive behavioral therapy (CBT) for adults with panic disorder. ii.
- Trial name
- Meltz (NCT07892885)
- Testing
- Meltz
- Volunteers
- 120 people
- Sponsor
- AIMNEXT
Cognition Improvement, Cognition Function
A Clinical Study to Evaluate the Effects of a Supplement on Cognitive Function
This is a virtual, two-armed, randomized, triple-blinded, placebo-controlled clinical trial that will last 16 weeks. Participants will take the supplement or a placebo product twice daily and complete questionnaires at Baseline…
- Trial name
- NCT07883525
- Testing
- Necternal Supplement
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Necternal LLC
Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis
Cladribine vs Placebo for Non-active Progressive Multiple Sclerosis (CLASP-MS).
The purpose of the study is to evaluate the efficacy and safety of subcutaneously administered cladribine versus placebo to stop inflammation and treat disease progression of non-active secondary progressive multiple sclerosis.
- Trial name
- CLASP-MS (NCT05961644)
- Testing
- Cladribine Subcutaneous Injection, 0.9% Chloride Injection Sodium
- Where
- Poland
- Volunteers
- 188 people
- Sponsor
- Institute of Psychiatry and Neurology, Warsaw
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