Clinical trials: Cognitive Investigation
Healthy, Cognitive Impairment
PennPET Explorer Scanner Evaluation
Positron Emission Tomography (PET) is a procedure that uses a special type of machine to take pictures of the inside of the body after a radioactive drug is administered.
- Trial name
- NCT04617912
- Testing
- Long AFOV PennPET Explorer
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Tumor, Metastatic Brain Tumor
A Study of How Proton Beam Radiotherapy (PBRT) Affects Brain Function and Quality of Life in Children and Young Adults Undergoing Treatment for a Brain Tumor
The researchers are doing this study to find out if there are differences in the resting state brain networks of children and young adults (ages 6-25) after treatment with proton beam radiation therapy (PBRT).
- Trial name
- NCT05288439
- Testing
- Resting-state functional connectivity MRI, Neurocognitive battery with quality-of-life assessment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stress
The SENSE Study: Surgical ENvironment Stress Evaluation
Surgical procedures such as total hip and knee arthroplasty require a complex set of physical and cognitive skills, expert execution, and inevitably place a high stress load on the surgeon.
- Trial name
- SENSE (NCT07506330)
- Testing
- total joint arthroplasty
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Memory Loss
The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)
To investigate the efficacy and safety of donepezil in individuals with mild cognitive impairment on measures of cognition, global function and behavior.
- Trial name
- NCT00293176
- Testing
- Donepezil Hydrochloride
- Where
- 54 sites in United States
- Volunteers
- 821 people
- Sponsor
- Eisai Inc.
Stress
FeelSync: Tailoring Ecological Momentary Assessments and Interventions for Emotion Awareness, Regulation, and Mental Health Outcomes
This study investigates how different ways of reflecting on emotions in daily life influence emotional awareness, emotion regulation, and mental health.
- Trial name
- FeelSync (NCT06986850)
- Testing
- FeelSync mobile application, Ecological Momentary Assessment mobile application
- Where
- Netherlands
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Marta Marciniak
Mild Alzheimer's Disease, Mild Cognitive Impairment
Safety Study of HPP854 in Subjects With Mild Cognitive Impairment or a Diagnosis of Mild Alzheimer's Disease
This is a safety and tolerability study investigating the effect of HPP854 in subjects with mild cognitive impairment or a diagnosis of mild Alzheimer's disease.
- Trial name
- NCT01482013
- Testing
- HPP854
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- High Point Pharmaceuticals, LLC.
Elderly
Factors Associated With Cognitive Status in the Elderly
The aim of this study was to investigate the factors related to cognitive status in elderly individuals living in the community.
- Trial name
- NCT05051319
- Where
- Turkey (Türkiye)
- Volunteers
- 814 people
- Sponsor
- Pamukkale University
Stroke, Post Stroke
An Ecological Momentary Assessment Based Program to Support Self-Management for Post-stroke Patients
The goal of this feasibility study is to test whether a new approach that combines real-time symptom tracking (Ecological Momentary Assessment) with machine learning can help people recovering from a stroke to better manage…
- Trial name
- NCT07691411
- Testing
- Ecological Momentary Assessment based Self-management Program
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Memory Disorders, Alzheimer Disease
Evaluation of a Handheld Event Related Potential (ERP)/Quantitative Electroencephalography (qEEG) System (COGNISION™) as a Useful Cognitive Biomarker for Alzheimer's Disease.
The proposed study is designed to evaluate the performance of the COGNISION™ System as a tool to assist physicians in diagnosing Alzheimer's Disease (AD) in real-world clinical settings.
- Conditions
- Memory Disorders, Alzheimer Disease, Dementia, Cognitive Impairment
- Trial name
- COGNISION™ (NCT00938665)
- Testing
- COGNISION™ System
- Where
- 7 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Neuronetrix, Inc.
Anxiety, Depression
Online Cognitive Behaviour Therapy for Depression and Anxiety: Randomized Controlled Trial Varying Treatment Content
Anxiety and depression are prevalent and disabling conditions. Although cognitive behaviour therapy (CBT) has been shown to significantly reduce symptoms of anxiety and depression, access to the service is limited.
- Trial name
- NCT03684434
- Testing
- Online MI plus Online CBT, Online CBT
- Where
- Canada
- Volunteers
- 480 people
- Sponsor
- University of Regina
Craving
Cognitive and Affective Mechanisms Underlying an Olfactory Approach to Modify Cigarette Craving
The proposed study uses fMRI and behavioral measures in and outside the laboratory to investigate the neurobehavioral mechanisms underlying the impact of pleasant olfactory cues (OCs) on cigarette craving.
- Trial name
- OdorCrave (NCT04902469)
- Testing
- Pleasant Odor, Odor Blank
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder, Dysthymic Disorder
Cognitive Behavioral Therapy for Early-Onset Depression
Depression is a debilitating illness affecting large numbers of young people. In this study, children and adolescents ages 10 to 17 meeting criteria for clinical depression will participate in a 15-session group therapy…
- Trial name
- NCT00096642
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre for Addiction and Mental Health
Psychogenic Nonepileptic Seizures, Psilocybin
Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures
Psychogenic non-epileptic seizures (PNES) are functional paroxysmal motor disorders that may be clinically suggestive of epilepsy but are not associated with the electroencephysiological and electroencephalographic changes of…
- Trial name
- CRIPSY (NCT06647056)
- Testing
- Psilocybin, MRI
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prosthesis User, Cognitive Change
Evaluation of a Novel Bionic Foot, AMPfoot 4+
Background: Evaluating the use of a novel motorized ankle prosthesis during walking and under dual task circumstances is an important step in product development.
- Conditions
- Prosthesis User, Cognitive Change, Physical Activity
- Trial name
- NCT03530956
- Testing
- Ankle Mimicking Prosthetic Foot prototype 4+
- Where
- Belgium
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Irritable Bowel Syndrome
An Assessment of Cognitive Function in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common disorder affecting up to 20% of the general population. Despite the prevalence of the disorder, it remains poorly understood.
- Trial name
- NCT01304355
- Where
- 2 sites in Ireland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University College Cork
Healthy Volunteers
Training of Cross-cultural Competencies in Psychotherapists
The purpose of this study is to determine whether a web-based training program with text-based information as well as practical exercises can improve cross-cultural competencies in therapists.
- Trial name
- NCT03038347
- Testing
- Training, Education only
- Where
- Germany
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Post-operative Delirium, Cognitive Dysfunction
Effect of Epidural Analgesia on Burst Suppression
It has been shown in previous studies that burst suppression has an effect on the development of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD).
- Conditions
- Post-operative Delirium, Cognitive Dysfunction, Electroencephalography
- Trial name
- NCT05688449
- Testing
- Bupivacaine-fentanyl, Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bezmialem Vakif University
Transcranial Alternating Current Stimulation, Electroencephalography
Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease
To investigate the clinical effect neural mechanism of transcranial alternating current stimulation in early Alzheimer's disease
- Conditions
- Transcranial Alternating Current Stimulation, Electroencephalography, Early Alzheimer's Disease
- Trial name
- NCT06565143
- Testing
- Transcranial alternating current stimulation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Anhui Medical University
Cognitive Change
CMI-168 on Cognitive Function in Healthy Middle-aged Men and Women
The investigators propose to conduct the present study in order to primarily assess the effects of CMI-168 in neurocognition enhancement.
- Trial name
- NCT03612752
- Testing
- CMI-168
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cerebos Pacific Limited
Frail Elderly Syndrome
HOPE (Healthy Older People Everyday) To Age in Place
Certain clinical syndromes eg frailty, sarcopenia, dementia, depression, cognitive impairment, vision impairment, falls in older adults carry an increased risk for poor health outcomes and if identified early, can be prevented…
- Trial name
- NCT03797352
- Testing
- Multicomponent exercise
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
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