Clinical trials: Cognitive Investigation
Bipolar Disorder
MAPP: Imagery-focused Therapy for Bipolar Disorder
Bipolar Disorder (BD) (previously known as "manic depression") is a severe mental health illness affecting at least 1% of the population and with annual NHS cost estimated at £342 million.
- Trial name
- MAPP (NCT01981018)
- Testing
- Imagery-focused Cognitive Therapy (ImCT - psychotherapy based on CBT principles)
- Where
- 4 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Mild Cognitive Impairment (MCI)
Evaluation of the Effect of Healthy Lifestyle Intervention for Patients With Mild Cognitive Impairment
This clinical study aims to evaluate the feasibility and preliminary effectiveness of a comprehensive lifestyle intervention program for patients with mild cognitive impairment.
- Trial name
- NCT06942780
- Testing
- Exercise intervention, Social intervention, Dietary intervention
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Alzheimer Disease, Mild Cognitive Impairment
Multimodal Deep Learning for the Diagnosis and Assessment of Alzheimer's Disease
Alzheimer's disease (AD) is the most common dementia and has been one of the most expensive diseases with the highest lethality.
- Trial name
- NCT06081569
- Testing
- gait video; speech video; facial expression video;
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Dementia
CST+MST Intervention on People Living With Mild-to-moderate Dementia
Non-pharmacological interventions such as Cognitive Stimulation Therapy (CST) and physical activity are recommended for people living with mild-to-moderate dementia.
- Trial name
- CST+MST (NCT07625241)
- Testing
- Cognitive Stimulation Therapy and Motor Stimulation Treatment
- Where
- Italy
- Volunteers
- 421 people
- Sponsor
- Istituto Superiore di Sanità
Mild Cognitive Impairment
Evaluation of a Digital Neurorehabilitation Program Using Exergames for Adults With Mild Cognitive Impairment
The goal of this clinical trial is to learn whether a semi-autonomous digital telerehabilitation program using therapeutic video games ("exergames") can help improve quality of life and functional independence in older adults…
- Trial name
- NCT07423260
- Testing
- Digital exergame-based neurorehabilitation program, Individual conventional physiotherapy
- Where
- Spain
- Volunteers
- 38 people
- Sponsor
- European University of Madrid
Sickle Cell Anemia
The Montreal Cognitive Assessment.Test in Adults With Sickle Cell Disease
This study will assess the performances of the Montreal Cognitive Assessment (MoCA) to screen for cognitive impairment in adults with sickle cell anemia.
- Trial name
- EvaCAD (NCT05347043)
- Testing
- Montreal cognitive assessment
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Moyamoya Disease, Revascularization
The Evolution and Prognosis of Moyamoya Disease
To investigate the evolution of imaging appearances and cognitive function of Moyamoya disease (MMD) and to establish a prognosis evaluation system based on imaging biomarkers in MMD.
- Conditions
- Moyamoya Disease, Revascularization, Cognitive Impairment, Functional Impairment
- Trial name
- NCT05619068
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital
Mild Cognitive Impairment
Cognitive Stimulation Therapy and Olderly People With Mild Cognitive Impairment
The aim of this study is to examine the effect of cognitive stimulation therapy on cognitive status and apathy in elderly individuals with mild cognitive impairment.
- Trial name
- NCT06115785
- Testing
- Cognitive Stimulation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ejdane Coskun
Depression
Clinical and Economic Evaluation of Neurocognitively-Enhanced Online Cognitive Behavioural Therapy
To evaluate the clinical efficacy of online cognitive behavioural therapy supplemented with online neurocognitive remediation therapy to improve mood and cognition, decrease relapse rates and optimise work and occupational…
- Trial name
- OPTM (NCT04010643)
- Testing
- online cognitive behavioural therapy, online neurocognitive remediation therapy
- Where
- Denmark
- Volunteers
- 134 people
- Sponsor
- University of Southern Denmark
Cancer
BNT001 Digital Therapeutic Feasibility Pilot Study
This single arm phase II trial focused on cancer patients and cancer survivors in the Veterans Health Administration will gather data on feasibility, acceptability, ease of clinical implementation, and preliminary efficacy of…
- Trial name
- NCT04857008
- Testing
- BNT001
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Blue Note Therapeutics
Cognitive Function and Mood, Non-anaemic Iron Deficiency
Efficacy Evaluation of 16 Weeks' Dietary Supplementation With Iron Bis-glycinate Plus Vitamin C on Cognitive Function, Subjective Mood, Fatigue, Health and Well-being
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Trial name
- NCT04469010
- Testing
- Iron Bis-Glycinate Chelate and Vitamin C, Iron Bis-Glycinate Chelate
- Where
- United Kingdom
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Burnout, Professional, Stress, Psychological
Foundational Programs to Combat Clinician Stress
This is a prospective, randomized, controlled clinical trial in which clinicians from University of Pennsylvania Health Systems (UPHS) including Penn Medicine- Lancaster General Health (LGH) and Massachusetts General Hospital…
- Conditions
- Burnout, Professional, Stress, Psychological, Stress, Physiological, Psychological Well-Being
- Trial name
- FACCTS (NCT07220421)
- Testing
- Sudarshan Kriya Yoga (SKY) Breathing and Sahaj Meditation, Health Education Program (HEP)
- Where
- 6 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Brain Injuries, Cognitive Impairment
Occupational Therapy and Cognitive Challenges After Brain Injury
Background: There is a need for standardized interventions in community rehabilitation that can improve everyday task performance for older adults with cognitive challenges after acquired brain injury.
- Trial name
- NCT05148247
- Testing
- The Perceive, Recall, Plan and Perform System of Intervention
- Where
- 2 sites in Norway
- Volunteers
- 6 people
- Sponsor
- Norwegian University of Science and Technology
Cognitive Impairment, Mild, Dementia
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo.
- Conditions
- Cognitive Impairment, Mild, Dementia, Cardiovascular Diseases
- Trial name
- PREVENTABLE (NCT04262206)
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- 106 sites in United States, Puerto Rico
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Intergenerational Relations
The Development of an Intergenerational Movement Program for Grandchildren and Their Grandparents Using Co-creation
The aim of this study is to develop, evaluate and implement an intergenerational physical activity program for grandchildren and their grandparents using co-creation focusing on the promotion of (co-)physical activity as a…
- Trial name
- GRANDPACT (NCT06163638)
- Testing
- GRANDPACT Project
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Ghent
Injury as a Result of Positioning
Prospective Evaluation of Cognitive Outcomes After Anesthesia on Patients in the Beach Chair Position
The purpose of this study was to use Near Infrared Spectroscopy (NIRS) monitoring on participants undergoing shoulder surgery in the beach chair position (BCP) to determine cerebral desaturation events (CDE) and to further…
- Trial name
- BCP (NCT02674334)
- Testing
- NIRS, NIRS monitored not treated
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- West Virginia University
Sexual Offending Behavior
Project CONSENT: Cognitive Behavioral Therapy to Prevent Sexual Recidivism
The goal of this randomized controlled trial is to investigate the effects of cognitive behavioral therapy (CBT) on sexual recidivism risk in a Swedish sample of incarcerated men convicted of sexual offenses.
- Trial name
- NCT06098521
- Testing
- CONSENT
- Where
- 2 sites in Sweden
- Volunteers
- 228 people
- Sponsor
- Karolinska Institutet
Delirium, Postoperative Delirium
Stanford PIPRA Validation Study in an Elderly Orthopedic Population
The purpose of this study is to determine the accuracy of an AI-based tool in the prediction of postoperative delirium (POD), in a population at moderately high risk of developing this syndrome (i.e., elderly orthopedic…
- Conditions
- Delirium, Postoperative Delirium, Cognitive Impairment
- Trial name
- PIPRA-ORTHO (NCT06567574)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Stanford University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.