Clinical trials: Cognitive Symptom
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Analgesia, Sternotomy
Pecto-intercostal Fascial Block (PIFB) for Postop Analgesia Following Sternotomy in Cardiac Surgery Patients
The purpose of this randomized, triple-blinded, prospective, feasibility study is to compare postoperative analgesia provided by Pecto-intercostal Fascial Block (PIFB) when performed with local anesthetic solution with or without…
- Trial name
- NCT05676814
- Testing
- Pecto-intercostal Fascial Block (PIFB), PIFB with adjuvants
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Wake Forest University Health Sciences
Major Depressive Disorder
Predictors of Treatment Outcome With Cognitive Behavioral Therapy for Depression
The purpose of this research study is to learn whether specific types of brain imaging and psychological testing can predict how much benefit patients with depression will receive from a well-studied psychotherapy for depression…
- Trial name
- NCT01922219
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pain
Dorsal Penile Nerve Block for Rigid Cystoscopy in Men
This study will determine the effectiveness and safety of dorsal penile nerve block (DPNB) in men undergoing rigid cystoscopy.
- Trial name
- NCT02502487
- Testing
- Dorsal Penile Nerve Block, Ropivacaine, Tetracaine
- Where
- China
- Volunteers
- 258 people
- Sponsor
- West China Hospital
Development Delay, Behavior Problem
The Pro-Parenting Study: Helping Parents Reduce Behavior Problems in Preschool Children With Developmental Delay
The Pro-Parenting Study seeks to determine the added benefit of targeting both parenting stress and parent management strategies to more effectively reduce behavior problems among children with developmental delay (DD).
- Trial name
- NCT03599648
- Testing
- BPT-M, BPT-E
- Where
- 2 sites in United States
- Volunteers
- 959 people
- Sponsor
- University of Oregon
Primary Progressive Aphasia
Transcranial Direct Current Stimulation for Primary Progressive Aphasia
In the present sham-controlled study, the investigators examine whether tDCS could be used to enhance language abilities (e.g., picture naming) in individuals with primary progressive aphasia (PPA) primarily characterized by…
- Trial name
- NCT02928848
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
Pain
The Use of a Digital Application for Reporting Pain and Pain Management in Home Hospice
Poor adherence to pain management and high pain intensity associated with serious, advanced illness is a major public health concern.
- Trial name
- ePainSupport (NCT04869085)
- Testing
- e-PainSupport
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Cardiovascular Diseases, Acute Coronary Syndrome
MBCT Via Group Videoconferencing for Acute Coronary Syndrome Patients With Depressive Symptoms: A Pilot RCT
The aim of this study is to establish, in a pilot RCT (approx. N=50 participants) with a time- and attention-matched health enhancement control, (a) the feasibility of the recruitment procedures (screening, eligibility…
- Conditions
- Cardiovascular Diseases, Acute Coronary Syndrome, Depression
- Trial name
- NCT04799899
- Testing
- Adapted MBCT, Cardiac Health Enhancement
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Long COVID, Long COVID-19
RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms
This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs…
- Conditions
- Long COVID, Long COVID-19, Long COVID19
- Trial name
- NCT05965752
- Testing
- BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE
- Where
- 24 sites in United States
- Volunteers
- 328 people
- Sponsor
- Duke University
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Pain, Medical Abortion
Methadone and Medication Abortion
Pain has been recognized to be the most common and predictable side effect of medication abortion, causing significant distress associated with the process.
- Trial name
- NCT04941443
- Testing
- Methadone Pill, Ibuprofen
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Boston Medical Center
Multiple Sclerosis
Cognitive-behavior Therapy for MS-Related Chronic Pain
The purpose of this study is to evaluate the efficacy of a brief psychological intervention, cognitive-behavior therapy, for the management of persistent pain associated with Multiple Sclerosis.
- Trial name
- NCT00323271
- Testing
- Cognitive-behavior therapy, Interventional
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- US Department of Veterans Affairs
Knee Osteoarthritis
Feasibility of Pain Informed Movement for Knee OA
The pain experience and its associated mechanisms in people with knee osteoarthritis (OA) are known to be complex and multidimensional.
- Trial name
- NCT04954586
- Testing
- Pain Informed Movement
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McMaster University
Phantom Limb Pain
Predicting Pain Response to Transcranial Direct Current Stimulation for Phantom Limb Pain in Limb Amputees
This study explores the effects transcranial Direct Current Stimulation (tDCS, Soterix ©) on Phantom Limb Pain for patients experiencing chronic phantom limb pain in open-label study design.
- Trial name
- NCT02627495
- Testing
- transcranial Direct Current Stimulation (tDCS): (Soterix ©)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Spaulding Rehabilitation Hospital
Depression, Parkinson's Disease
Telehealth Cognitive Behavioral Therapy for Depression in Parkinson's Disease (PD)
When Veterans with Parkinson's disease (PD) suffer from depression, they are more likely to experience disease complications, interpersonal difficulties with caregivers, and poorer quality of life.
- Trial name
- TH-CBT (NCT02475954)
- Testing
- TH-CBT, Standard Care
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Contraception
Misoprostol With Intrauterine Device Insertion
The purpose of this study is to see if using misoprostol (a medication that softens the cervix) before placing an intrauterine device for contraception reduces pain in women who have never delivered a baby.
- Trial name
- NCT00613366
- Testing
- Misoprostol, Magnesium Oxide
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Developmental Language Disorder, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder: Verb Learning
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT06001866
- Testing
- Retrieval-based verb learning: Repeated Spaced Retrieval condition, Retrieval-based verb learning: Repeated Study condition
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Purdue University
Chronic Pain, Schizophrenia
Assessment and Treatment for Chronic Pain in Veterans With Serious Mental Illness
Chronic pain has a highly negative impact on Veterans, especially those with serious mental illness (SMI). Chronic pain leads to poorer mental health and physical functioning, and represents a critical obstacle to rehabilitation…
- Conditions
- Chronic Pain, Schizophrenia, Psychotic Disorders, Bipolar Disorder
- Trial name
- CPSMI (NCT04118283)
- Testing
- Cognitive Behavioral Therapy for Chronic Pain, Health and Wellness
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- VA Office of Research and Development
Cerebral Adrenoleukodystrophy (CALD)
A Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD)
This trial assessed the efficacy and safety of autologous cluster of differentiation 34 (CD34+) hematopoietic stem cells, transduced ex-vivo with Lenti-D lentiviral vector (also called elivaldogene autotemcel or eli-cel), for the…
- Trial name
- NCT01896102
- Testing
- Lenti-D Drug Product (eli-cel)
- Where
- 8 sites in United States, Argentina and 4 more
- Volunteers
- 32 people
- Sponsor
- Genetix Biotherapeutics Inc.
Caregiver Stress
Mindfulness-based Cognitive Coping for ADRD Caregivers
This project will evaluate the effectiveness of the Mindfulness-based Cognitive Coping (MCC) intervention to alleviate stress and depressive symptoms of caregivers of Individuals with Alzheimer's Disease and Related Dementia.
- Trial name
- NCT05979922
- Testing
- Mindfulness-based Cognitive Coping, Traditional Educational/Resources Program
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Photozig, Inc.
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