Clinical trials: Cognitive Training
Neural Connectivity
Neural Activation and Connectivity in Response to Exercise and Cognitive Training
The goal of this pilot study is to evaluate whether healthy, sedentary older adults have increased activation of specific brain areas, in response to exercise and cognitive training, in comparison to a control group, and whether…
- Trial name
- NAC (NCT01603771)
- Testing
- Blood Oxygen Level Dependent (BOLD) functional magnetic imaging (fMRI)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Exercise Performance, Exercise Recovery
Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Other Perceptual Indicators
The purpose of this study is to evaluate the dose-dependent effects of glucosyl-hesperidin (CITRAPEAK) supplementation on exercise performance, recovery indicators, blood flow, cognitive function, mood, sleep, and fuel…
- Conditions
- Exercise Performance, Exercise Recovery, Cognitive Function, Nitric Oxide
- Trial name
- HES (NCT06672952)
- Testing
- 400 mg CITRAPEAK® (glucosyl-hesperidin) supplementation, 200 mg CITRAPEAK® (glucosyl-hesperidin) supplementation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Cognitive Aging
The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
While an intellectually active and socially integrated lifestyle shows promise for promoting cognitive resilience, the mechanisms underlying any such effects are not well understood.
- Trial name
- MixedWM (NCT05672771)
- Testing
- Different Mixed Condition (DM), Different Single Condition (DS), Same Task (ST) Practice Control
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Health Behavior
Effect of Strength Training and Whole Body Vibration in Healthy Elderly
Quality of Life (Qol) is a complex concept which relates to the perception of subjective satisfaction, especially in elderly population.
- Trial name
- NCT01526109
- Testing
- Strength training group, Control group, Whole-body vibration training group
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidade Gama Filho
Subjective Cognitive Decline
REducing the Risk of COgnitive DEcline ad Dementia in Patients With Subjective Cognitive Decline Through an Immersive Virtual Reality and Telemedicine-based Multi-component Intervention: the SCD-ReCODED Study
Older adults with subjective cognitive decline (SCD) are at high risk of developing dementia and frequently experience subclinical symptoms (e.g., anxiety, depression) which are themselves associated with dementia and cognitive…
- Trial name
- SCD-ReCODED (NCT06429215)
- Testing
- Multi-component Intervention (MC-I): VR Cognitive training and Psychoeducation on health and lifestyle, Cognitive-only intervention (CO-I): VR Cognitive training (+ Psychoeducation active control), Active control intervention (AC-I): VR Cognitive active control + Psychoeducation active control
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Mild Cognitive Impairment
Aerobic Exercise Training in Mild Cognitive Impairment Study
This study is being done to find out whether regulation of brain blood flow is altered in patents with mild cognitive impairment (those who have memory problems but otherwise healthy) when compared with healthy elderly…
- Trial name
- AETMCI (NCT01146717)
- Testing
- Exercise, Balance training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Music Listening, Auditory Processing
Following the Sound of Music
The proposed study will enroll healthy older adult participants to examine the effectiveness of music listening activities to promote hearing and cognition.
- Conditions
- Music Listening, Auditory Processing, Attention
- Trial name
- NCT07772765
- Testing
- Music Listening with Attentional prompts, Music Listening, Tone listening with Attentional prompts
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Phobias, Claustrophobia
Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training
There are two specific aims for this study. Aim 1 is to test whether low-level laser therapy (LLLT) can enhance the efficacy of fear extinction training in the modification of pathological fear.
- Conditions
- Phobias, Claustrophobia, Social Phobia
- Trial name
- NCT02926352
- Testing
- Extinction Training, Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Well-Being, Psychological, Cognition
Promoting Mental and Cognitive Health in Old Age Through Scalable Evidence-based Interventions
Mental and cognitive health are key determinants of healthy and successful aging. These two domains are closely intertwined: while chronic stress can impair cognitive functioning, cognitive decline may in turn heighten stress and…
- Conditions
- Well-Being, Psychological, Cognition, Ageing
- Trial name
- PROMISE (NCT07072338)
- Testing
- Stress management training, Multidomain cognitive training, Social activities
- Where
- Switzerland
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Sustained Attention, Cognitive Performance
Acute Effects of Moderate-Intensity Continuous Exercise Versus HIIT on Cognitive Performance and Psychophysiological Responses in Physically Active Adults
This study aims to compare the immediate effects of two common types of exercise-moderate-intensity continuous exercise and high-intensity interval training (HIIT)-on attention, alertness, and physiological responses in…
- Conditions
- Sustained Attention, Cognitive Performance, Cognitive Performance During Physical Activity
- Trial name
- EXCOG (NCT07400432)
- Testing
- Moderate-Intensity Continuous Exercise (MICE), High-Intensity Interval Training (HIIT)
- Where
- Saudi Arabia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Qassim University
Cognitive-affective Exercises, Engaging Exercises
Trial of a Nationwide Cognitive-Affective Remediation Training Intervention in Depression
The objective is to examine the efficacy of computerized interventions for increasing well-being and cognitive functioning. The study will seek to validate emerging online delivery methods of psychiatric assessment and treatment.
- Trial name
- NCT02075190
- Testing
- Therapeutic Computerized intervention, Nontherapeutic computerized intervention
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Stanford University
Social Anxiety
Arousal Training for Social Anxiety Disorder
The primary objective of the study is to examine the safety, usability and preliminary efficacy of a novel arousal-based biofeedback system in alleviating social anxiety.
- Trial name
- NCT02493010
- Testing
- Arousal-based biofeedback system
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Old Age; Dementia, Aging
Compensatory Brain Activity in Older Adults.
There are two important aspects in which the present project will allow to enrich our understanding of compensatory brain activity in older adults.
- Conditions
- Old Age; Dementia, Aging, Cognitive Decline
- Trial name
- BrainAct (NCT06235840)
- Testing
- working memory adaptive training, multi-domain non-adaptive control training
- Where
- Poland
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Kazimierz Wielki University
Aging
Neural Correlates of Successful Cognitive Aging
Normal aging is associated with gradual cognitive declines. These mild neurocognitive disturbances affect daily functioning, health status, and quality of life, and likely account for the roughly $2.9 billion lost by the elderly…
- Trial name
- NCT02628548
- Testing
- Cognitive training program
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention and Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- Quest-Tablet (NCT05625425)
- Testing
- LabyrinthVR software, Labyrinth Tablet software, Labyrinth VR wireless
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Community-Dwelling Older Adults, Aging
The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip Strength in Community-Dwelling Older Adults: A Mixed-Methods Research
Block-building activities represent a promising tool for enhancing cognitive and hand function in older adults. When integrated with technological support, they offer personalized training advantages; however, their comprehensive…
- Conditions
- Community-Dwelling Older Adults, Aging, Cognitive Decline, Hand Dexterity
- Trial name
- NCT07315724
- Testing
- Technology-Assisted Block Training Program
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Cognitive Decline, Dementia Prevention
Small Monetary Incentives for Digital Cognitive Training Adherence in Community-Dwelling Older Adults
This study aims to find out whether small daily monetary rewards can help older adults living in the community to regularly complete digital cognitive training.
- Trial name
- NCT07913243
- Testing
- Digital cognitive training, Monetary incentive 0.2 CNY/day, Monetary incentive 0.5 CNY/day
- Where
- 5 sites in China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Older People
Cognitive Exergame Training on Dual-Task Cost and Balance Stability in Older Adults
Balance stability requires both motor and cognitive (mental) functions working together. Balance stability may decrease when performing two tasks at the same time (dual task), as cognitive and motor tasks compete for performing a…
- Trial name
- NCT05395676
- Testing
- Exergame home training programme
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Older Adults, Balance
Effect of Physical-Cognitive Training in Older Adults
The study compares the impact of physical-cognitive exercises using Blazepod device versus conventional balance training on multiple outcomes in older adults aged 70 and above.
- Trial name
- NCT07199426
- Testing
- Physical-Cognitive Training, Conventional Balance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Medipol University